Xinyao Li,Xiaojie Zhu,Wenzhe Li et al.
Xinyao Li et al.
The c-Jun N-terminal kinase (JNK) pathway is an evolutionarily conserved signaling cascade that regulates development, stress responses, and pathogenesis. While aberrant JNK activation is linked to cancer and neurodegeneration, its regulato...
BAP1 and USP1 cooperate to regulate FANCD2 stability and cell proliferation in mesothelioma cells [0.03%]
BAP1和USP1在间皮瘤细胞中合作调节FANCD2稳定性及细胞增殖
Koya Suzuki,Shinichi Kiyonari,Jo Nishino et al.
Koya Suzuki et al.
BRCA1-associated protein 1 (BAP1) is frequently inactivated in pleural mesothelioma and functions as a tumor suppressor through its deubiquitinating activity. In this study, we investigated the context-dependent interplay between BAP1 and u...
Fibroblast-mediated KRAS activation in double-negative prostate cancer [0.03%]
前列腺双阴性癌中的成纤维细胞介导的KRAS活化
Taiki Kamijima,Kouji Izumi,Kaoru Hiratsuka et al.
Taiki Kamijima et al.
When androgen receptor (AR) signaling is suppressed, prostate cancer progression is inhibited; however, many patients eventually relapse, developing castration-resistant prostate cancer (CRPC). Recently, the incidence of double-negative CRP...
Hepatokine ORM2 suppresses pathological ferritinophagy to prevent acute tissue injury [0.03%]
肝细胞因子ORM2通过抑制病理性的铁蛋白自噬来预防急性组织损伤
Hongyi Tang,Shu Wang,Fang Liu et al.
Hongyi Tang et al.
Acute tissue injuries trigger rapid cellular damage, but cell-intrinsic protective programs attenuate pathology through regulatory axes. Here, we demonstrate that Orosomucoid 2 (ORM2), a hepatokine, is significantly upregulated during drug-...
Targeting the TRIM25-AGO2-miR-148b-5p-ABCC1 axis overcomes chemoresistance in non-small cell lung cancer [0.03%]
靶向TRIM25-AGO2-miR-148b-5p-ABCC1轴可克服非小细胞肺癌的化疗耐药性
Zihan Zhou,Ran Chen,Lian Li et al.
Zihan Zhou et al.
Despite significant advances in the treatment of non-small cell lung cancer (NSCLC), acquired resistance remains a major obstacle in advanced stages. Elucidating the molecular mechanisms underlying resistance is crucial for improving clinic...
Protective versus deleterious roles of pyroptosis in Mycobacterium avium and Mycobacterium marinum infections [0.03%]
分枝杆菌感染中pyroptosis的保护作用与有害作用
Wanbin Hu,Federico Pagliaro,Herman P Spaink et al.
Wanbin Hu et al.
Mycobacterium avium, a slow-growing nontuberculous mycobacterium (NTM), is the main cause of life-threatening NTM infections, which are globally on the rise. Unlike Mycobacterium tuberculosis and Mycobacterium marinum, M. avium lacks ESX-1,...
Correction: Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2 [0.03%]
补：arteimate通过靶向prdx1和prdx2诱导弥漫性大b细胞淋巴瘤细胞发生铁死亡
Xiaohui Liu,Liyi Zeng,Jing Liu et al.
Xiaohui Liu et al.
Published Erratum
Cell death & disease. 2026 Apr 29;17(1):402. DOI:10.1038/s41419-026-08776-0 2026
Jin Wu,Kaiyu Shen,Qi Tang et al.
Jin Wu et al.
Colon adenocarcinoma (COAD), the most common subtype of colon cancer, often arises from adenomas. However, the mechanisms driving the adenoma-to-adenocarcinoma transition remain unclear, hindering early intervention and treatment. Single-ce...
Retraction Note: microRNA-17 functions as an oncogene by downregulating Smad3 expression in hepatocellular carcinoma [0.03%]
撤回 notice: microRNA-17通过下调 Smad3 表达在肝细胞癌中发挥致癌作用
Zhufeng Lu,Xiuhua Li,Yongfeng Xu et al.
Zhufeng Lu et al.
Vitamin D receptor isoform VDRA suppresses hepatocellular tumorigenesis by restricting YAP nuclear localization [0.03%]
维生素D受体异构体VDRA通过限制YAP的核定位来抑制肝细胞肿瘤发生
Lizhi Li,Shiwei He,RuoYa Wang et al.
Lizhi Li et al.
Hepatocellular carcinoma (HCC) frequently arises from uncontrolled proliferation of hepatocyte epithelium, a process potently driven by the transcriptional regulator yes-associated protein (YAP). Although 1,25(OH)₂D₃, the active form of v...