Proteasomal-dependent CHK1 degradation leads to DNA damage accumulation in ALS cellular model systems [0.03%]
与ALS相关的细胞模型系统中丝裂窗口检查点蛋白1的蛋白酶体依赖性的降解导致DNA损伤的积累
Stefania Modafferi,Valentina Silenzi,Anna Garbelli et al.
Stefania Modafferi et al.
Amyotrophic lateral sclerosis (ALS) is characterised by the aggregation of TDP-43 and mutant FUS in the cytoplasm of affected motor neurons. Accumulation of DNA damage is emerging as a novel correlative trait of ALS. We recently showed that...
Correction: The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway [0.03%]
纠正：通过MAPK途径增强IRAK1 mRNA稳定性的m6A阅读蛋白HNRNPC促进胶质瘤进展
Jun-Jun Chen,Tian-Zhu Lu,Tao Wang et al.
Jun-Jun Chen et al.
Published Erratum
Cell death & disease. 2026 May 5;17(1):406. DOI:10.1038/s41419-026-08775-1 2026
RILPL2 suppresses metabolic reprogramming and progression of cervical cancer by attenuating LDHA protein stability and inhibiting H3K18 lactylation [0.03%]
RILPL2通过降低LDHA蛋白稳定性和抑制H3K18乳酸化来抑制宫颈癌的代谢重组和进展
Yujing Shi,Zhaoyue Zhang,Jin Liu et al.
Yujing Shi et al.
Cervical cancer (CC) is a prevalent malignancy among women worldwide with considerable incidence and mortality. Recent studies have suggested that the Rab-interacting lysosomal protein-like 2 (RILPL2) acts as a tumor suppressor and plays an...
Multi-omics reveals CXCR4 drives immune escape in colorectal cancer via metabolic reprogramming and immune microenvironment remodeling [0.03%]
多组学揭示CXCR4通过代谢重塑和免疫微环境重建介导结直肠癌免疫逃逸
Chengle Zhu,Yuting Liu,Shaopeng Xu et al.
Chengle Zhu et al.
Colorectal cancer (CRC) is one of the most common malignant tumors with the highest incidence and mortality rates worldwide. Immune checkpoint blockade (ICB) therapy has revolutionized the landscape of cancer treatment; however, most patien...
The histone methyltransferase NSD3 oncogene triggers ribosomal DNA transcription, interfering with FOSL2 in cancer [0.03%]
组蛋白甲基转移酶NSD3癌基因通过干扰FOSL2在癌症中触发核糖体DNA转录
Federica Corigliano,Marco Gaviraghi,Alessio Lupi et al.
Federica Corigliano et al.
Ribosome biogenesis is pervasively enhanced in cancer, and yet, how the expression of ribosomal RNA genes is triggered remains largely unknown. We found that the long isoform of the histone methyltransferase NSD3, NSD3L, one of the most fre...
STUB1-induced polyubiquitination of SIK3 in alveolar type 2 epithelial cells alleviates severity and outcomes of acute lung injury [0.03%]
STUB1诱导的SIK3蛋白聚泛素化修饰调控肺泡II型上皮细胞焦亡改善急性肺损伤Severity和Outcome
Feng Tian,Nianlin Xie,Daixing Zhong et al.
Feng Tian et al.
Disruption in alveolar type 2 epithelial cells (AT2s) homeostasis by oxidative stress plays an essential role in the pathogenesis of acute lung injury (ALI). However, significant discrepancies remain in understanding the mechanisms for AT2 ...
Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells [0.03%]
HERC2诱导DDX21泛素化通过NUCKS1-p21 / p27轴在结直肠癌细胞中诱导休眠样表型以促进放射抗性
Yuqi Xiao,Mingyuan He,Han Yao et al.
Yuqi Xiao et al.
Cellular dormancy in colorectal cancer (CRC) significantly contributes to therapeutic resistance, tumor recurrence, and metastasis, resulting in poor prognosis. However, the underlying molecular mechanisms remain poorly understood. Here, we...
SEL1L3 suppresses colorectal cancer cell growth and metastasis by preventing endoplasmic reticulum-associated degradation of STING [0.03%]
SEL1L3通过防止内质网相关降解抑制STING促进结直肠癌细胞生长和转移
Hui Zhang,Wenli Qian,Mengying Li et al.
Hui Zhang et al.
Endoplasmic reticulum associated degradation (ERAD) plays pivotal role in protein homeostasis and quality control in normal and cancer cells, yet the regulatory mechanism of ERAD remains elusive, especially regarding its ubiquitination func...
Hypermethylation of ZNF154 promotes malignant potential of ovarian cancer cells by diminishing ZNF154/KAP1-mediated ROMO1 repression [0.03%]
ZNF154高甲基化通过减少ZNF154/KAP1介导的ROMO1抑制促进卵巢癌细胞恶性潜力
Mingbiao Wei,Yuxia Xu,Ling Deng et al.
Mingbiao Wei et al.
Accumulating evidence demonstrates that the silencing of tumor suppressor genes by aberrant DNA methylation contributes to the initiation and progression of ovarian cancer (OC), while the systemic methylation profile and the key driver meth...
Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes [0.03%]
癌性恶病质会诱导棕色脂肪组织发生衰老重塑并促进脂肪细胞分泌促恶病质因子S100A9
Claudia Di Biagio,Flavia Tortolici,Francesco Gaudioso et al.
Claudia Di Biagio et al.
Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome characterized by progressive loss of fat and lean mass, systemic inflammation, and poor therapeutic responsiveness. While brown adipose tissue (BAT) is traditionally cons...