Six1 haploinsufficiency is associated with activation of NF-κB and TNF-related transcriptional signatures in aging mice [0.03%]
六价一不足与衰老小鼠中NF-κB和TNF相关转录特征的激活有关
Tianxu Guo,Han Liu,Junjun Ma et al.
Tianxu Guo et al.
The Six1 (SIX homeobox 1) gene is pivotal in renal and pulmonary development and differentiation. Its dysregulation is implicated in oncogenesis and tumor progression via enhancing cell proliferation and delaying senescence. However, whethe...
Characterization of ADGRG6 as a potential molecular oncotarget of pancreatic cancer [0.03%]
ADGRG6在胰腺癌中的分子肿瘤标志物潜能研究
Qian-Hui Gu,Xiao-Ren Zhu,Jian-Zhuo Jiang et al.
Qian-Hui Gu et al.
Identifying novel therapeutic targets for pancreatic cancer (PC) is crucial for improving patient outcomes. This study identified the functions, expression, and associated mechanisms of adhesion G protein-coupled receptor G6 (ADGRG6/ GPR126...
Micropeptide SCAPEP triggers lung adenocarcinoma tumorigenesis via regulating autophagy by promoting CDK15-mediated phosphorylation of vimentin [0.03%]
微肽SCAPEP通过促进CDK15介导的波形蛋白磷酸化调节自噬从而触发肺腺癌的发生发展
Xuefei Shi,Qiuhui Li,Fengqi Nie et al.
Xuefei Shi et al.
Lung adenocarcinoma is one of the most common forms of lung cancer with a low five-year survival rate. The roles of the novel proteins and peptides encoded by circular RNAs (circRNAs) in cancer are emerging. However, the functions and under...
mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway [0.03%]
雷帕霉素靶蛋白抑制通过抑制ATF4-MTHFD2通路增强泛RAF-MEK抑制的抗肿瘤疗效
Feiyang Cai,Fan Huang,Christophe Goncalves et al.
Feiyang Cai et al.
BRAF V600 inhibitors are clinically approved for the treatment of BRAFV600-mutant melanoma in combination with a MEK inhibitor, but are ineffective in other melanoma subtypes. Moreover, pan-RAF inhibitors, such as belvarafenib, when combine...
Hippocampal Satb2 regulates the cognitive function of adult mice through pleiotrophin [0.03%]
钙调蛋白Satb2通过多肽素调节成年小鼠的认知功能
Xin-Ren Yu,Yu-Bing Wang,Zhi-Yi Tu et al.
Xin-Ren Yu et al.
The special AT-rich sequence-binding protein 2 (SATB2) is associated with human cognitive ability. Mutations in the SATB2 gene lead to SATB2-associated syndrome (SAS), characterized by severe intellectual disability. SATB2 is mainly express...
Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients [0.03%]
脓毒症相关淋巴细胞亚群的年龄差异及共同途径：老年人和儿童患者的比较研究
Xianwen Wang,Qihang Huang,Zhihong Zuo et al.
Xianwen Wang et al.
Sepsis disproportionately affects older adults and children, two immunologically vulnerable extremes of age. Yet sepsis is superimposed on distinct baselines-immunosenescence in the elderly and immune immaturity in neonates and young childr...
Correction: Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection [0.03%]
纠正：由兴奋性毒性诱导的神经生长因子受体TrkB-FL逆向运输调节高尔基体稳定性并成为卒中神经保护的目标
Gema María Esteban-Ortega,Elena Torres-Campos,Margarita Díaz-Guerra
Gema María Esteban-Ortega
Published Erratum
Cell death & disease. 2026 May 5;17(1):405. DOI:10.1038/s41419-026-08785-z 2026
Inhibition of Pellino-1 reverts the progression and tyrosine kinase inhibitor resistance in chronic myeloid leukemia [0.03%]
抑制Pellino-1可逆转慢性粒细胞白血病的进展和酪氨酸激酶抑制剂耐药性
Qian Zhou,Guangsen Xu,Zhuoran Li et al.
Qian Zhou et al.
BCR-ABL1, derived from structural chromosome rearrangements, is the driver mutation in chronic myeloid leukemia (CML). Targeting BCR-ABL1 for degradation is an ideal therapeutic strategy for CML, however, the regulatory mechanisms controlli...
Granulocyte differentiation arrest in HAX1-deficient cells, demonstrated in a new in vitro model of a certain phenotypic aspects of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake [0.03%]
HAX1缺陷细胞中粒系分化阻滞的新体外模型：由无效的脂滴自噬和脂肪酸摄取导致的某些Kostmann病表型方面特征
Maciej Wakula,Milena Jablonowska,Mateusz Chmielarczyk et al.
Maciej Wakula et al.
Molecular mechanisms underlying congenital neutropenia in patients with HAX1 deficiency are not clear at the moment. HAX1 deficiency was shown to result in the arrest of neutrophil differentiation. Our studies of the effect of HAX1 deficien...
Correction: SLC7A11 upregulation via AR and NEDD4L ubiquitination contributes to ferroptosis inhibition and enzalutamide resistance in castration-resistant prostate cancer [0.03%]
纠正：通过AR和NEDD4L泛素化调节SLC7A11的上调有助于去势抵抗性前列腺癌铁死亡抑制和恩杂鲁胺耐药性
Min Tang,Luotong Xue,Bao Wang et al.
Min Tang et al.
Published Erratum
Cell death & disease. 2026 May 5;17(1):407. DOI:10.1038/s41419-026-08741-x 2026