CENPT prevents renal cell carcinoma against ferroptosis by enhancing the synthesis of glutathione [0.03%]
CENPT通过增强谷胱甘肽合成预防肾细胞癌发生铁死亡
Han Yang,Zongliang Zhang,Ninghan Feng et al.
Han Yang et al.
Cancer is characterized by chromosomal instability (CIN), which leads to tumor heterogeneity and other malignant features. CIN is caused by abnormal centromere and kinetochore function, which results in aneuploidy, rearrangements, and micro...
Post-translational modification of transcription factors: perspectives in vascular medicine [0.03%]
转录因子的翻译后修饰：血管医学的新视角
Elena Astanina,Elisa Setten,Francesco Boccalatte et al.
Elena Astanina et al.
In vascular diseases, the perturbation of key metabolic pathways is extensively studied and recognized as both a causal factor and a consequence in disease onset and progression. Similarly, the dysregulation of the transcriptional landscape...
SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation [0.03%]
无赖氨酸的肿瘤抑制因子p14ARF的SUMO化作用对抗其泛素依赖性降解
Ahmed El Motiam,Yanis H Bouzaher,Haifen Chen et al.
Ahmed El Motiam et al.
p14ARF is a lysine-less tumor suppressor that enhances SUMOylation of its interactors. Although p14ARF is known to interact with the E2 SUMO conjugating enzyme UBC9, the link between ARF and SUMOylation is poorly understood and the potentia...
Glucose-induced STUB1-GOT2 axis promotes aspartate synthesis and mitochondrial dysfunction in bladder cancer [0.03%]
葡萄糖诱导的STUB1-GOT2轴促进膀胱癌中的天冬氨酸合成和线粒体功能障碍
Yunqiang Xiong,Qianxi Dong,Hongji Hu et al.
Yunqiang Xiong et al.
Aberrant glucose metabolism, a characteristic of malignant tumors, contributes to the development and progression of bladder cancer (BCa). However, the underlying mechanism by which aberrant glucose metabolism promotes BCa progression is st...
Invasive lobular carcinoma: integrated multi-omics analysis reveals silencing of Argininosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance [0.03%]
侵袭性小叶癌：整合多组学分析揭示鸟氨酸琥珀酸转氨酶的沉默及核苷酸生物合成在托瑞米芬耐药中的激活作用
Annapurna Gupta,Fouad Choueiry,Jesse Reardon et al.
Annapurna Gupta et al.
Invasive Lobular Carcinoma (ILC), a distinct subtype of breast cancer, is hallmarked by E-Cadherin loss, slow proliferation, and strong hormone receptor positivity. ILC faces significant challenges in clinical management due to advanced sta...
Artesunate induces ferroptosis in diffuse large B-cell lymphoma cells by targeting PRDX1 and PRDX2 [0.03%]
艺术酸盐通过靶向PRDX1和PRDX2诱导弥漫性大B细胞淋巴瘤细胞发生铁死亡
Xiaohui Liu,Liyi Zeng,Jing Liu et al.
Xiaohui Liu et al.
Diffuse large B-cell lymphoma (DLBCL), the most prevalent non-Hodgkin lymphoma (NHL), is characterized by rapid growth and an unfavorable prognosis. Artesunate (ART), a derivative of Artemisinin, is a widely recognized antimalarial drug tha...
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma [0.03%]
干扰素γ通过缓解蛋白变性压力促进GSDME介导的焦亡从而增强TKIs在肝癌中的疗效
Xiaoxiao Li,Fujia Lu,Jie Zhou et al.
Xiaoxiao Li et al.
Tyrosine kinase inhibitors (TKIs) are the standard treatment for advanced hepatocellular carcinoma (HCC). However, their therapeutic efficacy is often limited by drug resistance, primarily driven by tumoral intrinsic mechanisms. In this stu...
PLIN2 promotes colorectal cancer progression through CD36-mediated epithelial-mesenchymal transition [0.03%]
PLIN2通过CD36介导的上皮间质转化促进结直肠癌进展
Fan Yang,Ying Li,Xue Shang et al.
Fan Yang et al.
Colorectal cancer (CRC) is one of the most common malignant tumors with high incidence and mortality. The challenge remains to construct reliable prognostic prediction models and to further elucidate the key molecular mechanisms of tumor pr...
Rb substantially compensates for the double loss of p130 and p107 in adult but not embryonic neural stem cell lineages [0.03%]
RB在成人神经干细胞谱系中但不是胚胎神经干细胞谱系中可大幅补偿p130和p107的双重丢失
Reem Swaidan,Ahmad Daher,Anthony T Bejjani et al.
Reem Swaidan et al.
The Retinoblastoma (Rb) family of pocket proteins (p107, Rb, and p130) controls all aspects of neurogenesis from stem cell activation to long-term neuronal survival in the brain. Previous studies have reported non-overlapping, often complem...
Mesenchymal stromal cells highly expressing Sca-1 promote breast cancer lung metastasis through recruiting myeloid cells [0.03%]
高度表达Sca-1的间充质基质细胞通过募集髓系细胞促进乳腺癌肺转移
Lijuan Cao,Yanan Li,Minghui Ou et al.
Lijuan Cao et al.
Mesenchymal stem/stromal cells (MSCs) are integral components of the tumor microenvironment and critical for the colonization of disseminated cancer cells; specifically, stem cell antigen (Sca-1) is recognized as a surface marker of MSCs. I...