Unveiling DEFB1 as a novel driver and promising therapeutic target in lung adenocarcinoma [0.03%]
DEFB1在肺腺癌中的新型驱动基因和治疗靶点作用机制研究
Jiaqi Liang,Yanjun Yi,Junkan Zhu et al.
Jiaqi Liang et al.
Lung adenocarcinoma, one of the most prevalent malignancies, underscores the urgency of identifying genes linked to its proliferation and prognosis for developing targeted therapies. In this study, we performed genome-wide CRISPR/Cas9 scree...
Retraction Note: Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects [0.03%]
撤回 notice: 补充 bmp4 表达改善血管内皮前体细胞的母体糖尿病诱导的凋亡和神经管缺陷
Songying Cao,E Albert Reece,Wei-Bin Shen et al.
Songying Cao et al.
CD5L promotes efferocytosis and resolution of retinal ischemic injury [0.03%]
CD5L促进视网膜缺血损伤的促凋亡作用和缓解效应
Rami A Shahror,Bushra Zaman,Piyanan Chuesiang et al.
Rami A Shahror et al.
Ischemia-induced retinopathy is a defining feature of prevalent ocular conditions, including diabetic retinopathy and central retinal artery or vein occlusion. Therapeutic interventions for ischemic retinopathies show limited efficacy and a...
Dual-targeting nanoparticles enhance microglial P2Y12R expression to promote neuronal mitophagy for repairing spinal cord injury [0.03%]
双靶向纳米颗粒通过增强小胶质细胞P2Y12R表达促进神经元线粒体自噬以修复脊髓损伤
Zhenming Tian,Hong Li,Yunheng Jiang et al.
Zhenming Tian et al.
Spinal cord injury (SCI) leads to severe mitochondrial dysfunction and ROS cascade, with microglia playing a dual role in both exacerbating damage and providing neuroprotection. Recent evidence has highlighted the importance of P2Y12R in mi...
Klebsiella pneumoniae LPS drives stromal-mediated repression of p53 and colorectal cancer chemoresistance [0.03%]
肺炎克雷伯氏菌LPS驱动结直肠癌基质介导的p53抑制及耐药性产生
Konstantinos Fragkoulis,Barbara Łasut-Szyszka,Ákos Végvári et al.
Konstantinos Fragkoulis et al.
The gut bacterial microbiota is increasingly recognized as a key modulator of colorectal cancer (CRC) initiation, progression and response to therapy. However, the mechanisms by which bacteria influence the response to anticancer drugs rema...
Decoding the CAF-TAM axis: multi-omics dissection and therapeutic targeting of stromal-immune crosstalk in the tumor microenvironment [0.03%]
CAF-TAM轴的解码：肿瘤微环境中基质-免疫互作的多组学解析及治疗靶点探索
Yage Fu,Mei Li,Shiwang Wu et al.
Yage Fu et al.
Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are pivotal stromal and immune components of the tumor microenvironment (TME) that orchestrate immune evasion, metabolic reprogramming, and therapeutic resistance....
Correction: Chloroquine overcomes chemotherapy resistance and suppresses cancer metastasis by eradicating dormant cancer cells [0.03%]
纠正：氯喹通过消灭休眠的癌细胞来克服化疗耐药性并抑制癌症转移
Marina A Mikeladze,Liubov S Kuznetcova,Elena Y Komarova et al.
Marina A Mikeladze et al.
Published Erratum
Cell death & disease. 2026 Apr 17;17(1):391. DOI:10.1038/s41419-026-08552-0 2026
Dedifferentiation-driven oncogenic stemness promotes tumor-sustaining adaptability in the intestinal epithelium [0.03%]
去分化诱导的肿瘤干细胞样性质促进肠道上皮组织中的肿瘤维持性适应性
Kylee Zgeib,Thompson Hui,Simon Garcia et al.
Kylee Zgeib et al.
Intestinal tumorigenesis can occur via two distinct routes: bottom-up tumorigenesis occurs from mutations sustained in the Lgr5⁺ stem cells, whereas top-down tumorigenesis is driven by dedifferentiation of epithelial cells near the intesti...
Correction: Investigating the role of EGFR signalling in muscle dystrophies: implications for Duchenne muscular dystrophy [0.03%]
关于EGFR信号通路在肌营养不良中的作用的研究更正：杜氏肌营养不良的启示
Esther Fernández-Simón,Ainoa Tejedera-Villafranca,Xiomara Fernández-Garabay et al.
Esther Fernández-Simón et al.
Published Erratum
Cell death & disease. 2026 Apr 17;17(1):392. DOI:10.1038/s41419-026-08544-0 2026
Correction: RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer [0.03%]
纠正：RASAL2通过MAPK/SOX2途径抑制RAS GTP酶激活蛋白的干性和上皮间质转化在膀胱癌中的作用
Ke Hui,Yang Gao,Jun Huang et al.
Ke Hui et al.
Published Erratum
Cell death & disease. 2026 Apr 17;17(1):393. DOI:10.1038/s41419-026-08630-3 2026