Unmeasured human transcription factor ChIP-seq data shape functional genomics and demand strategic prioritization [0.03%]
未测定的人类转录因子ChIP-seq数据塑造功能基因组学并要求进行战略性优先排序
Saeko Tahara,Haruka Ozaki
Saeko Tahara
Transcription factor (TF) chromatin immunoprecipitation followed by sequencing (ChIP-seq) is essential for identifying genome-wide TF-binding sites (TFBSs), and the collected datasets offer a variety of opportunities for downstream analyses...
Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression via PI3K/AKT activation and immunosuppressive microenvironment remodeling [0.03%]
TPD52和TPD52L2通过激活PI3K/AKT和重塑免疫抑制微环境在胃癌进展中的双重致癌作用
Hailong Li,Xiaqing Gao,Shuangming Guo et al.
Hailong Li et al.
Aim: TPD52 (tumor protein D52) and TPD52L2 (tumor protein D52-like 2), members of the TPD52 gene family, have been implicated in multiple malignancies. However, their roles in gastric cancer (GC) remain elusive. Herein, w...
Identification of pathogenic cell types and shared genetic loci and genes for Alzheimer's disease and inflammatory bowel disease [0.03%]
阿尔茨海默病和炎症性肠病的致病细胞类型、共有遗传位点及基因鉴定
Jingjing Zhang,Yuqing Yan,Liqin Han et al.
Jingjing Zhang et al.
Background: Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, but the underlying intrinsic link between Alzheimer's disease (AD) and inflam...
Integration of single cell multiomics data by deep transfer hypergraph neural network [0.03%]
基于深度迁移超图神经网络的单细胞多组学数据整合
Yulong Kan,Zhongxiao Zhang,Yingjie Wang et al.
Yulong Kan et al.
Multi-omics characterization of individual cells offers remarkable potential for analyzing the dynamics and relationships of gene regulatory states across millions of cells. How to integrate multimodal data is an open problem, existing inte...
INTS7 modulates cell proliferation and apoptosis via promoting cell cycle progression in lung adenocarcinoma [0.03%]
INTS7通过促进细胞周期进程调节肺癌腺癌细胞增殖和凋亡
Yaming Liu,Tengfei Huang,Dehua Zeng et al.
Yaming Liu et al.
The evolutionarily conserved Integrator complex, which is composed of over 10 subunits, orchestrates diverse RNA-processing events such as 3'-end maturation of small nuclear RNAs (snRNAs), transcription termination of RNA Polymerase II, and...
A survey of biclustering and clustering methods in clustering different types of single-cell RNA sequencing data [0.03%]
单细胞RNA测序不同数据类型聚类的双聚类和聚类方法综述
Chaowang Lan,Xiaoqi Tang,Caihua Liu
Chaowang Lan
Single-cell RNA sequencing (scRNA-seq) technology has garnered considerable attention as it enables the exploration of cellular heterogeneity from a single-cell perspective. Various unsupervised methods, such as biclustering and clustering ...
Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy [0.03%]
基因组视角下的噬菌体研究：抗菌药物耐药性检测和噬菌体治疗的新前沿
Basudha Banerjee,Sayanti Halder,Shubham Kumar et al.
Basudha Banerjee et al.
The misuse and overprescription of antibiotics have accelerated the rise of antimicrobial resistance (AMR), rendering many antibiotics ineffective and leading to significant clinical challenges. The conventional treatment methods have becom...
Correction to: STAT3-dependent long non-coding RNA Lncenc1 contributes to mouse ES cells pluripotency via stabilizing Klf4 mRNA [0.03%]
Correction to：STAT3依赖的长链非编码RNA Lncenc1通过稳定Klf4 mRNA参与小鼠ES细胞多能性研究
Published Erratum
Briefings in functional genomics. 2025 Jan 15:24:elaf012. DOI:10.1093/bfgp/elaf012 2025
VirusImmu: a novel ensemble machine learning approach for viral immunogenicity prediction [0.03%]
基于病毒免疫原性预测的新型集成机器学习方法ViruSimmu
Jing Li,Zhongpeng Zhao,ChengZheng Tai et al.
Jing Li et al.
The viruses threats provoke concerns regarding their sustained epidemic transmission, making the development of vaccines particularly important. In the prolonged and costly process of vaccine development, the most important initial step is ...
Enhancer RNA in cancer: identification, expression, resources, relationship with immunity, drugs, and prognosis [0.03%]
癌症中的增强子RNA：鉴定、表达、资源、与免疫的关系、药物和预后
Ruijie Zhang,Zhengxin Chen,Tianyi Li et al.
Ruijie Zhang et al.
Enhancer RNA (eRNA), a type of non-coding RNA transcribed from enhancer regions, serves as a class of critical regulatory elements in gene expression. In cancer biology, eRNAs exhibit profound roles in tumorigenesis, metastasis, and therape...