Supernatants from oral epithelial cells and gingival fibroblasts modulate human immunodeficiency virus type 1 promoter activation induced by periodontopathogens in monocytes/macrophages [0.03%]
口腔上皮细胞和牙龈成纤维细胞的上清液可调节病原菌诱导的单核细胞/巨噬细胞中的人免疫缺陷病毒Ⅰ型启动子活化
O A González,J L Ebersole,C B Huang
O A González
Bacterial and host cell products during coinfections of Human Immunodeficiency Virus type 1-positive (HIV-1(+)) patients regulate HIV-1 recrudescence in latently infected cells (e.g. T cells, monocytes/macrophages), impacting highly active ...
DNA from Porphyromonas gingivalis and Tannerella forsythia induce cytokine production in human monocytic cell lines [0.03%]
牙龈卟啉单胞菌和福斯杆菌的DNA诱导人单核细胞系产生细胞因子
S E Sahingur,X-J Xia,S Alamgir et al.
S E Sahingur et al.
Toll-like receptor 9 (TLR9) expression is increased in periodontally diseased tissues compared with healthy sites indicating a possible role of TLR9 and its ligand, bacterial DNA (bDNA), in periodontal disease pathology. Here, we determine ...
Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT [0.03%]
口腔甲基球菌的抗原组II分子伴侣可能与人类分子伴侣CCT发生交叉反应
K Yamabe,H Maeda,S Kokeguchi et al.
K Yamabe et al.
Methanobrevibacter oralis is an archaeal species frequently isolated from sites of severe periodontitis. However, its pathogenic roles remain unclear. Here, we aimed to isolate group II chaperonin from M. oralis and examine its antigenicity...
Synergistic effects of lipopolysaccharides from periodontopathic bacteria on pro-inflammatory cytokine production in an ex vivo whole blood model [0.03%]
牙周致病菌脂多糖对体外全血模型中炎性细胞因子产生的协同作用效应
C Bodet,D Grenier
C Bodet
Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia have been strongly associated with chronic periodontitis. This disease is characterized by an accumulation of inflammatory cells in periodontal tissue and subgingival s...
Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells [0.03%]
牙龈卟啉单胞菌感染通过Akt信号通路使凋亡蛋白Bad磷酸化并抑制其功能
L Yao,C Jermanus,B Barbetta et al.
L Yao et al.
Porphyromonas gingivalis, a self-limiting oral pathogen, can colonize and replicate in gingival epithelial cells (GECs). P. gingivalis-infected GECs are protected from mitochondrion-dependent apoptosis, partially through activation of phosp...
L M Shaddox,B Alfant,J Tobler et al.
L M Shaddox et al.
This study evaluated the reproducibility of in-vitro-grown biofilms, initiated with subgingival plaque from patients with periodontal disease, and continued through several cycles by re-inoculating new biofilms from previously grown biofilm...
A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives [0.03%]
一种ω-3多不饱和脂肪酸及其酯类衍生物的新活性作用
C B Huang,J L Ebersole
C B Huang
Fish oil, enriched in omega-3 polyunsaturated fatty acids (n-3 PUFA), is widely used as a dietary or nutritional supplement with numerous benefits, including as an anti-inflammatory particularly linked to atherosclerosis. While n-3 PUFA hav...
Porphyromonas gingivalis infection-induced tissue and bone transcriptional profiles [0.03%]
牙龈卟啉单胞菌感染引起的组织和骨转录谱型
A Meka,V Bakthavatchalu,S Sathishkumar et al.
A Meka et al.
Porphyromonas gingivalis has been associated with subgingival biofilms in adult periodontitis. However, the molecular mechanisms of its contribution to chronic gingival inflammation and loss of periodontal structural integrity remain unclea...
Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis [0.03%]
肺炎链球菌蛋白PavA对鼻咽定植及败血症发病具有重要作用
A Kadioglu,H Brewin,T Härtel et al.
A Kadioglu et al.
Summary The pneumococcal cell surface protein PavA is a virulence factor associated with adherence and invasion in vitro. In this study we show in vivo that PavA is necessary for Streptococcus pneumoniae D39 colonization of the murine upper...
A metaproteomic analysis of the human salivary microbiota by three-dimensional peptide fractionation and tandem mass spectrometry [0.03%]
三维肽段分离与串联质谱联合的唾液微生物组元蛋白质组分析
J D Rudney,H Xie,N L Rhodus et al.
J D Rudney et al.
Metagenomics uses gene expression patterns to understand the taxonomy and metabolic activities of microbial communities. Metaproteomics applies the same approach to community proteomes. Previously, we used a novel three-dimensional peptide ...