Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems [0.03%]
变异链球菌毒力和牙菌斑形成的分子调节机制：揭示VicRK和LiaSR双组分系统的相互作用
Niher Tabassum Snigdha,Ruaa Abdullah Alamoudi,Nuha Saad Alghamdi et al.
Niher Tabassum Snigdha et al.
Streptococcus mutans is one of the primary causes of dental caries and is often found in persistent endodontic infections, primarily due to its ability to form acidogenic, aciduric and therapeutically recalcitrant biofilms. The VicRK and Li...
Characteristics of the Health-Associated Oral Microbiome in Young Nonhuman Primates [0.03%]
年轻非人灵长类动物与健康相关的口腔微生物群的特征分析
J L Ebersole,O A Gonzalez
J L Ebersole
Nonhuman primates have been shown to develop periodontitis with clinical and demographic features similar to humans. This preclinical disease model is well-positioned to advance the elucidation of novel biologic-based preventive and therape...
GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1-cAMP/PKA Pathway in the Cross-Kingdom Biofilms [0.03%]
变异链球菌中的GcrR通过Ras1-cAMP / PKA信号通路抑制假丝酵母白色素在跨界的生物膜中的形态转换
Bin Zhang,Shihao Hou,Anqi Zhang et al.
Bin Zhang et al.
The dual-species biofilms formed by Streptococcus mutans and Candida albicans exhibit enhanced cariogenic potential due to the production of extracellular polysaccharides (EPSs). The response regulator GcrR in S. mutans negatively regulates...
The ComEA/ComEC Operon is Critical for Nitrosative Stress Tolerance by an Oral Commensal [0.03%]
硝酸盐应激耐受性口腔共生菌的ComEA/ComEC operon基因操纵子至关重要
Sara E Edmonds,Hernan Grenett,Priscilla Grenett et al.
Sara E Edmonds et al.
Oral commensal streptococci play a large role in mediating microbial homeostasis. Our prior work has demonstrated that hydrogen peroxide (H2O2) produced by oral commensal streptococci can react with salivary nitrite (NO2) and generate perox...
Ginsenoside Compound K Plays an Anti-Inflammatory Role in Gingival Epithelial Cells Stimulated With Porphyromonas gingivalis by Regulating Pyruvate Kinase M2 [0.03%]
高良姜素复合物K通过调节丙酮酸激酶M2在gingipain刺激的牙龈上皮细胞中发挥抗炎作用
Luxin Jin,Lin Lu,Yang Jiao et al.
Luxin Jin et al.
Background: Globally prevalent periodontitis, an inflammatory disease, may be associated with glucose metabolism disorders. Pyruvate kinase M2 (PKM2), the key enzyme of glycolysis, is potentially implicated in periodontit...
UCHL1 Exacerbates Periodontitis by Coordinating Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Macrophages [0.03%]
UCHL1通过协调巨噬细胞中的线粒体功能障碍和内质网应激加剧牙周炎
Yun Yuan,Shengjia Ye,Hanxiao Xue et al.
Yun Yuan et al.
Background: Given the pivotal role of macrophages in both the progression and regenerative phases of periodontitis, targeting macrophage-mediated immunity represents a novel therapeutic strategy for periodontitis manageme...
Porphyromonas gingivalis Outer Membrane Vesicles-Associated DNA Triggers Inflammation by Inducing IL-6 in Astrocytes [0.03%]
牙龈卟啉单胞菌外膜囊泡相关的DNA通过诱导星形胶质细胞产生IL-6来诱发炎症反应
Ayu Takai,Kaya Yoshida,Yuka Hiroshima et al.
Ayu Takai et al.
Porphyromonas gingivalis (Pg), a key pathogen in periodontal disease, is suggested to be involved in the progression of Alzheimer's disease (AD); however, the molecular mechanism remains unclear. We previously reported that Pg-released oute...
Streptococcus mutans CcpA Promotes Biofilm Exopolysaccharide Production and Virulence Gene Expression [0.03%]
变异链球菌CcpA促进生物被膜外多糖生成及毒力基因表达
Yujie Zhang,Zhanyi Chen,Meiling Jing et al.
Yujie Zhang et al.
Streptococcus mutans is a key cariogenic pathogen of dental caries due to its strong ability to synthesize extracellular glucans and form biofilms. Glucosyltransferases, encoded by gtfB/C/D genes in S. mutans, are responsible for producing ...
Random Mutagenesis in Porphyromonas gingivalis Enables Isolation of Mutants With Enhanced Secreted Protease Activity [0.03%]
分段突变筛选获得分泌蛋白酶活性增强的牙龈卟啉单胞菌变异体
Takeru Nakabayashi,Satoshi Yuhara,Kosei Tanaka
Takeru Nakabayashi
Porphyromonas gingivalis is a key pathogen in periodontitis, with secreted proteases as major virulence factors. We developed a screening method to generate and identify P. gingivalis mutants with elevated protease activity. Mutations were ...
Differences Between Oral Neutrophils and Neutrophils Isolated From the Blood of Healthy Donors [0.03%]
健康供体口腔中性粒细胞与血液中性粒细胞的差异研究
Svetlana N Pleskova,Nikolay A Bezrukov,Ekaterina D Nikolaeva et al.
Svetlana N Pleskova et al.
The morphological and viscoelastic properties of blood neutrophils and neutrophils isolated from the oral cavity of the same donor were compared using scanning ion conductance microscopy. It was found that cell morphology, including morphom...