Gingival fibroblast responsiveness is differentially affected by Porphyromonas gingivalis: implications for the pathogenesis of periodontitis [0.03%]
牙龈纤维母细胞对齿垢密螺旋体的不同反应及其对牙周炎发病机制的影响
N Scheres,W Crielaard
N Scheres
In periodontitis, tissue damage results mainly from aberrant host responses to oral microorganisms. Fibroblasts can play an important role in this. Gingival fibroblasts do not develop tolerance against the lipopolysaccharide of Porphyromona...
Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis [0.03%]
苯甲氨衍生物可抑制牙龈卟啉单胞菌的毒力
E Fröhlich,T Kantyka,K Plaza et al.
E Fröhlich et al.
We have previously shown that benzamidine-type compounds can inhibit the activity of arginine-specific cysteine proteinases (gingipains HRgpA and RgpB); well-known virulence factors of Porphyromonas gingivalis. They also hinder in vitro gro...
Conservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex [0.03%]
牙密螺旋体prcB- prcA- prtP位点的保存及重新注释：编码齿质溶解酶（CTLP）蛋白酶复合物
M P Goetting-Minesky,V Godovikova,J J Li et al.
M P Goetting-Minesky et al.
Interstrain differences in antigenic surface proteins may reflect immunological pressure or differences in receptor specificity of the antigen. Treponema denticola exhibits considerable interstrain variability in its major surface protein (...
C J Wright,L H Burns,A A Jack et al.
C J Wright et al.
Establishment of a community is considered to be essential for microbial growth and survival in the human oral cavity. Biofilm communities have increased resilience to physical forces, antimicrobial agents and nutritional variations. Specif...
Phenotypic characterization of the foldase homologue PrsA in Streptococcus mutans [0.03%]
变异链球菌分子伴侣PrsA同源物的表型特征分析
L Guo,T Wu,W Hu et al.
L Guo et al.
Streptococcus mutans is generally considered to be the principal etiological agent for dental caries. Many of the proteins necessary for its colonization of the oral cavity and pathogenesis are exported to the cell surface or the extracellu...
Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis [0.03%]
牙龈卟啉单胞菌GppX杂合两组分系统调控的 regulon
T Hirano,D A C Beck,C J Wright et al.
T Hirano et al.
The periodontal pathogen Porphyromonas gingivalis experiences a number of environmental conditions in the oral cavity, and must monitor and respond to a variety of environmental cues. However, the organism possesses only five full two-compo...
Pseudomonas aeruginosa lipopolysaccharide inhibits Candida albicans hyphae formation and alters gene expression during biofilm development [0.03%]
铜绿假单胞菌脂多糖抑制白色念珠菌菌丝形成并改变生物被膜发育过程中的基因表达
H M H N Bandara,B P K Cheung,R M Watt et al.
H M H N Bandara et al.
Elucidation of bacterial and fungal interactions in multispecies biofilms will have major impacts on understanding the pathophysiology of infections. The objectives of this study were to (i) evaluate the effect of Pseudomonas aeruginosa lip...
Comparative Study
Molecular oral microbiology. 2013 Feb;28(1):54-69. DOI:10.1111/omi.12006 2013
Comparative genomic hybridization and transcriptome analysis with a pan-genome microarray reveal distinctions between JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans [0.03%]
比较基因组杂交和泛基因组芯片的转录组分析揭示了Aggregatibacter actinomycetemcomitans JP2和非JP2基因型之间的差异
Y Huang,W Kittichotirat,M P A Mayer et al.
Y Huang et al.
It was postulated that the highly virulent JP2 genotype of Aggregatibacter actinomycetemcomitans may possess a constellation of distinct virulence determinants not found in non-JP2 genotypes. This study compared the genome content and the t...
Comparative Study
Molecular oral microbiology. 2013 Feb;28(1):1-17. DOI:10.1111/omi.12005 2013
Treponema denticola improves adhesive capacities of Porphyromonas gingivalis [0.03%]
牙龈卟啉单胞菌的粘附能力可受益于齿密螺旋体的影响
V Meuric,B Martin,H Guyodo et al.
V Meuric et al.
Porphyromonas gingivalis, an important etiological agent of periodontal disease, is frequently found associated with Treponema denticola, an anaerobic spirochete, in pathogenic biofilms. However, interactions between these two bacteria are ...
Comparative Study
Molecular oral microbiology. 2013 Feb;28(1):40-53. DOI:10.1111/omi.12004 2013
Role of MyD88-dependent and MyD88-independent signaling in Porphyromonas gingivalis-elicited macrophage foam cell formation [0.03%]
MyD88依赖性和非依赖性信号在牙龈卟啉单胞菌诱导的巨噬细胞泡沫细胞形成中的作用研究
Y B Shaik-Dasthagirisaheb,N Huang,M T Baer et al.
Y B Shaik-Dasthagirisaheb et al.
Clinical studies and experimental modeling identify a potential link between periodontal disease and periodontal pathogens such as Porphyromonas gingivalis and atherosclerosis and formation of macrophage foam cells. Toll-like receptors and ...
Comparative Study
Molecular oral microbiology. 2013 Feb;28(1):28-39. DOI:10.1111/omi.12003 2013