A Defined Artificial Saliva Medium Allows Characterization of the Hypothiocyanite Response of Streptococcus sanguinis and Streptococcus mutans [0.03%]
定义的人工唾液培养基可表征链球菌和变异链球菌的亚硫酸氢盐响应
Avery D Lieber,Drashti Vaghasia,Christopher W Hamm et al.
Avery D Lieber et al.
Hypothiocyanite (OSCN-/HOSCN) is an antimicrobial molecule found at high concentrations in saliva. HOSCN is thought to differentially affect oral streptococci, since noncariogenic streptococci (e.g. Streptococcus sanguinis) possess HOSCN re...
Harnessing the Regulatory Effects of Streptococcus mutans Two-Component Signal Transduction Systems for Therapeutic Interventions Against Dental Caries [0.03%]
利用链球菌两组分信号转导系统调节效应治疗牙齿龋病
Bingrun Qiu,Yalan Deng,Zhiheng Yi et al.
Bingrun Qiu et al.
Streptococcus mutans is considered the main pathogen causing dental caries and has a strong ability to establish biofilms and respond to environmental stimuli, which are essential for its survival and cariogenicity. Fourteen two-component s...
Streptococcus mutans Collagen-Binding Protein Cnm Is a Multifunctional Adhesin: A Structural Investigation [0.03%]
链球菌素Cnm是一种多功能粘附蛋白：结构研究
Joshua L Mieher,Norbert Schormann,Ren Wu et al.
Joshua L Mieher et al.
The collagen-binding adhesin Cnm is a known virulence factor of Streptococcus mutans. It is present in specific serotypes (mostly e, f, and k strains) of S. mutans and belongs to the LPXTG family of cell wall-anchored surface adhesins. Here...
Systematic Analysis of Lysine Succinylation in Streptococcus mutans [0.03%]
变异链球菌组蛋白 lysine succinylation 的系统分析研究
Ting Tong,Ziyi Yang,Xiaoqiong Li et al.
Ting Tong et al.
Lysine succinylation (Ksuc) is a novel post-translational modification (PTM), which regulates biological functions in bacteria. Streptococcus mutans has been identified as a predominant cariogenic pathogen responsible for the initiation and...
Fretibacterium: Exploring Its Pathogenic Potential in Oral Infectious Diseases [0.03%]
口腔感染性疾病中Fretibacterium的致病潜力探究
Lisha Liang,Pengbo Liu,Dongzhe Song
Lisha Liang
Oral infectious diseases, particularly inflammatory periodontal lesions, exert a substantial impact on healthcare systems and economies, as acknowledged by the World Health Organization. The prevailing consensus attributes the onset of oral...
Transcriptional Regulon Controlled by Tyrosine Phosphatases in Porphyromonas gingivalis [0.03%]
牙龈卟啉单胞菌中的酪氨酸磷酸酶调控的转录调节物
Gatphan Atassi,Kendall S Stocke,Richard J Lamont
Gatphan Atassi
Tyrosine phosphorylation/dephosphorylation post-translational modification (PTM) of proteins in bacteria can control their function and location. PTM of transcriptional regulators and DNA-binding proteins, as well as components of their sig...
Tolerance Induced by Porphyromonas gingivalis Altered Inflammatory Responses in Mice [0.03%]
牙龈卟啉单胞菌诱导的宿主耐受性及其对小鼠炎症反应的影响研究
Miao Yu,Wen-Bo Qian,Yuan-Chun Fang et al.
Miao Yu et al.
Tolerance refers to a hyporesponsiveness toward repeated stimulations with bacteria and their virulence factors, which might exist in the development of periodontitis. To identify the roles of tolerance induced by Porphyromonas gingivalis (...
Role of Oral Microbes in Epithelial-Mesenchymal Transition in Cancer Progression [0.03%]
口腔微生物在癌症进展上皮间质转化中的作用
Divya Gopinath,Zhengrui Li,Marwan Mansoor Mohammed et al.
Divya Gopinath et al.
Epithelial-mesenchymal transition (EMT) is a fundamental biological process where epithelial cells lose their polarity and adhesion properties, acquiring mesenchymal characteristics such as enhanced migratory ability and invasiveness. Cells...
Marine-Derived Cyclo(l-Leucyl-l-Prolyl) Targets d-Alanylation of Lipoteichoic Acid to Combat Streptococcus mutans UA159 Mediated Dental Cariogenesis [0.03%]
海洋来源的环状二肽 cyc(lo-L-赖氨酰-l-脯氨酸)通过作用于链球菌细胞壁脂磷壁酸d-丙氨酰化来抑制致龋细菌变异株UA159的生长及产酸能力研究
Ravichellam Sangavi,Nambiraman Malligarjunan,Shunmugiah Karutha Pandian et al.
Ravichellam Sangavi et al.
With the growing threat of antimicrobial resistance (AMR), antivirulence strategies present a promising alternative to traditional antibiotics, particularly in dentistry. Dental caries, a chronic biofilm-associated disease primarily driven ...
Zixue Lei,Qizhao Ma,Xuedong Zhou et al.
Zixue Lei et al.
Multifunctional gingipains are trypsin-like enzymes secreted extracellularly by Porphyromonas gingivalis, which require delicate transit and processing to be activated in different mature forms. This review manages to reconstruct each proce...