The Outcome of Intracellular Selenomonas sputigena and its Impact on Gingival Keratinocytes [0.03%]
胞内塞雷莫那氏菌(Sputigena sputigena)的结局及其对牙龈角质形成细胞的影响
Colin G Hawkes,Travis J Chiarelli,Doaa N Abdallah et al.
Colin G Hawkes et al.
Selenomonas sputigena is an understudied oral pathobiont associated with periodontitis and dental caries. We recently demonstrated that S. sputigena binds to gingival epithelial cells (GECs), where afterwards the bacterium causes robust in ...
Functional Analysis of Treponema denticola Periplasmic Flagella: Roles of FlaB1, FlaB2, and FlaB3 in Morphology and Motility [0.03%]
Treponema denticola周鞭毛的功能分析：FlaB1、FlaB2和FlaB3在形态与运动中的作用
Chen-Hsuan Chiu,Mari Fujita,Keiji Nagano
Chen-Hsuan Chiu
Treponema denticola is a Gram-negative, anaerobic spirochete associated with periodontal disease. It navigates highly viscous environments using periplasmic flagella located between the inner and outer membranes. The flagellum is composed o...
Neutrophil Activation Decreases Ability to Kill Oral Streptococcus gordonii [0.03%]
中性粒细胞活化降低了杀死口腔链球菌戈登菌的能力
Kiana T Bynum,Michelle Panasiewicz,Jason G Kay
Kiana T Bynum
As first responders, neutrophils are a vital component of the host defense against oral pathogens, and their function is critical in preventing the progression of periodontal diseases. Streptococcus gordonii, a generally commensal oral bact...
Porphyromonas gingivalis-Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein-1 Canonical Signaling [0.03%]
牙龈卟啉单胞菌毒力脂质通过高迁移率族蛋白-1经典信号通路独立方式促进破骨细胞生成
Chiaki Yamada,Gang Peng,James A Johnson Jr et al.
Chiaki Yamada et al.
Periodontal bacterial pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) accelerate inflammatory osteoclastogenesis, resulting in alveolar bone loss. The core PAMP and DAMP prototype molecules ar...
Expanded Functional Characterization and Optimization of Protein Expression in Treponema denticola Shuttle Plasmids [0.03%]
齿密螺旋体穿梭质粒的蛋白质表达功能表征和优化
M Paula Goetting-Minesky,Valentina Godovikova,Prakaimuk Saraithong et al.
M Paula Goetting-Minesky et al.
Oral spirochetes are among the small group of keystone pathogens contributing to dysregulation of periodontal tissue homeostasis, leading to breakdown of the tissue and bone supporting the teeth in periodontal disease. Of the more than 60 o...
Olivier Claisse,Cas Mosterd,Claire Le Marrec et al.
Olivier Claisse et al.
Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages i...
The Oral Microbiota, Its Evolution, and Aspects of Support for Oral Health [0.03%]
口腔微生物群及其演变和促进口腔健康方面的作用
Svetlana Pleskova,Nikolay Bezrukov
Svetlana Pleskova
Over the years, humanity has accumulated knowledge about the pathogens of infectious diseases and the ability of the human body to resist external aggression. In the last century, it became clear that the normal microflora of the human body...
Apelin-12 Attenuates LPS-Induced Cellular Senescence in Human Dental Pulp Cells via SIRT6-Mediated Pathways: Implications for Gingivitis Management [0.03%]
人牙髓细胞中APL-12通过SIRT6介导的途径减弱LPS诱导的细胞衰老：对牙龈炎管理的意义
Lin Zhang,Dan Luo,Li Bai
Lin Zhang
Microbial infections and lipopolysaccharide (LPS)-induced senescence in human dental pulp cells (hDPCs) play a significant role in gingivitis etiology. However, the role of Apelin-12 in oral diseases, particularly its modulation of cellular...
Long Noncoding RNA Malat1 and Neat1 Associated With Dysbiotic Microbiome and Epithelial-Mesenchymal Transition in Periodontitis [0.03%]
与牙周病中失调的微生物组和上皮间质转化相关的长链非编码RNA MALAT1和NEAT1
Saif M Al-Mufti,Ali A Abdulkareem,Nibras H Chasib et al.
Saif M Al-Mufti et al.
Introduction: The regulatory mechanisms of epithelial-mesenchymal transition (EMT) involved in periodontitis pathogenesis are poorly understood. Consequently, this study aimed to investigate the association of the long no...
Genomic Insights Into the Treponema Genus: Taxonomic Resolution of Treponema vincentii and Description of Two Novel Species, Treponema plautii sp. nov. and Treponema sinense sp. nov [0.03%]
解密钩端螺旋体属的基因组：Treponema vincentii 的分类解析及两种新型物种 Treponema plautii 和 Treponema sinense 的描述
Jordan Y H Fong,Man Lung Yeung,Tsz Tuen Li et al.
Jordan Y H Fong et al.
Objectives: Periodontal disease, a global health concern, is strongly associated with oral treponemes. However, the taxonomy of some species remains unresolved, hindering our understanding of their roles in disease. This ...