Loss of signal transducer and activator of transcription 3 in osteoblasts impaired the bone healing in inflammatory microenvironment [0.03%]
骨炎性微环境下的成骨细胞信号转导及转录激活因子3丢失抑制骨折愈合
Jingyi Feng,Zijing Huang,Jiarui Lu et al.
Jingyi Feng et al.
Introduction: This study aimed to investigate the effect of Stat3 on the osteoblast-mediated bone healing in the inflammatory lesion. Methods: ...
A conditional gene expression system in Porphyromonas gingivalis for study of the secretion mechanisms of lipoproteins and T9SS cargo proteins [0.03%]
牙龈卟啉单胞菌条件性基因表达系统用于研究脂蛋白和T9SS效应蛋白的分泌机制
Yuko Sasaki,Mikio Shoji,Takayuki Sueyoshi et al.
Yuko Sasaki et al.
The Gram-negative anaerobe, Porphyromonas gingivalis, is known to be a pathogen associated with chronic periodontitis. P. gingivalis possesses virulence factors such as fimbriae and gingipain proteinases. Fimbrial proteins are secreted to t...
Functional profile of oral plaque microbiome: Further insight into the bidirectional relationship between type 2 diabetes and periodontitis [0.03%]
口腔菌斑微生物组的功能谱系：进一步探索2型糖尿病和牙周炎之间双向关系的洞察力
Nicoletta Favale,Roberto Farina,Alberto Carrieri et al.
Nicoletta Favale et al.
Increasing evidence support the association between the oral microbiome and human systemic diseases. This association may be attributed to the ability of many oral microbes to influence the inflammatory microenvironment. Herein, we focused ...
Kendall S Stocke,Richard J Lamont
Kendall S Stocke
One-carbon metabolism (OCM) pathways are responsible for several functions, producing a number of one-carbon unit intermediates (formyl, methylene, methenyl, methyl) that are required for the synthesis of various amino acids and other biomo...
miR-27a-5p alleviates periodontal inflammation by targeting phosphatase and tensin homolog deleted on chromosome ten [0.03%]
微RNA-27a-5p通过靶向染色体丢失的磷酸酶和张力蛋白同源物缓解牙周炎
Li Deng,Peng-Cheng Huo,Mei-Ting Feng et al.
Li Deng et al.
Introduction: MicroRNAs (miRNAs), a type of non-coding RNA, have been demonstrated to be essential posttranscriptional modulators in oral diseases and inflammatory responses. However, the specific role of miR-27a-5p in pe...
GroEL of Porphyromonas gingivalis-induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells [0.03%]
牙龈卟啉单胞菌GroEL通过下调内皮前体细胞中血栓调节蛋白的表达来诱导microRNA并加速肿瘤新生血管生成
Feng-Yen Lin,Yi-Ting Tsai,Chun-Yao Huang et al.
Feng-Yen Lin et al.
We found that GroEL in Porphyromonas gingivalis accelerated tumor growth and increased mortality in tumor-bearing mice; GroEL promoted proangiogenic function, which may be the reason for promoting tumor growth. To understand the regulatory ...
The involvement of CdhR in Porphyromonas gingivalis during nitric oxide stress [0.03%]
牙龈卟啉单胞菌中CdhR在一氧化氮胁迫下的作用
Marie-Claire Boutrin,Arunima Mishra,Charles Wang et al.
Marie-Claire Boutrin et al.
Porphyromonas gingivalis, the causative agent of adult periodontitis, must gain resistance to frequent oxidative and nitric oxide (NO) stress attacks from immune cells in the periodontal pocket to survive. Previously, we found that, in the ...
Human papillomavirus and Epstein-Barr virus co-infection in oral and oropharyngeal squamous cell carcinomas: A systematic review and meta-analysis [0.03%]
人乳头瘤病毒和EB病毒共感染对口腔及口咽鳞癌的影响：系统评价和Meta分析
Rifat Rahman,Mushfiq H Shaikh,Divya Gopinath et al.
Rifat Rahman et al.
Squamous cell carcinoma of the oral cavity (OSCC) is the most common head-and-neck malignancy. Importantly, we are experiencing an alarming rise in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) globally. Oncogenic viruses, ...
Gingipains are the important virulence factors of Porphyromonas gingivalis downregulating B10 cells [0.03%]
gingipains是通过下调B10细胞来促进牙龈卟啉单胞菌致病的重要毒力因子
Hang Zou,Niu Zhou,Xiao Cheng et al.
Hang Zou et al.
Porphyromonas gingivalis is a keystone pathogen in periodontitis. Our previous study indicated that periodontitis induced by P. gingivalis increased the percentage of CD19+ B cells but decreased the ratio of IL-10-producing regulatory B cel...
Small noncoding RNA in Streptococci: From regulatory functions to drug development [0.03%]
链球菌中的小非编码RNA：从调控功能到药物开发
Yang Yang,Liu Wang,Liu Liu et al.
Yang Yang et al.
Streptococci are a genus of gram-positive coccus of spherical bacteria, including many commensal bacteria and opportunistic pathogens that threaten the public health system. Small noncoding RNAs (sRNAs) are a class of noncoding RNAs regulat...