Cell-Specific Functions of the BAI/ADGRB Subfamily of Adhesion G-Protein Coupled Receptors [0.03%]
BAI/ADGRB亚家族粘附G蛋白偶联受体的细胞特异性功能
Haifa A Alsharif,Sushant Bhatnagar
Haifa A Alsharif
G protein-coupled receptors (GPCRs) are key regulators of various physiological processes and remain the most targeted class of proteins in drug development. Although significant progress has been made in understanding many GPCR families, a...
Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model [0.03%]
非搏动性肺血流量在经典的绵羊Glenn模型中诱导肺血管内皮功能障碍
Jonathan Hyde,Michael A Smith,Naveen Swami et al.
Jonathan Hyde et al.
Background: Pulmonary vascular disease (PVD) in patients with single ventricular heart disease following the partial cavalpulmonary connection (Glenn) is a significant source of morbidity. However, the etiology of pulmona...
Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease [0.03%]
内皮细胞多样性与功能障碍对心血管疾病的影响
Anna E Williams,Luke S Dunaway,Zuzanna J Juśkiewicz et al.
Anna E Williams et al.
Endothelial cells (ECs) are functionally heterogeneous, even in vascular beds within the same organ. As the key cell type lining the vascular lumen, ECs regulate vascular tone (control of blood vessel diameter), permeability of molecules, w...
Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells [0.03%]
BMP/TGF-β信号转导的干扰：人肺微血管内皮细胞中AQP1和TGFB1的调节
Chrysi Keskinidou,Nikolaos S Lotsios,Kostas A Papavassiliou et al.
Chrysi Keskinidou et al.
Pulmonary arterial hypertension (PAH) is a chronic disorder with high fatality rates, and its progression is highly associated with the genetic background. Alongside pathogenic variants in genes central to the BMP/TGF-β signaling pathway, ...
The Role and Research Progress of Cystathionine β-Synthase in the Female Reproductive System [0.03%]
胱硫醚-β-合成酶在女性生殖系统中的作用及研究进展
Huajing Wang,Ling Zhang,Yi Liu
Huajing Wang
Cystathionine β-synthase (CBS) is a pivotal catalytic enzyme in the transsulfuration pathway, widely expressed in various organs of the female reproductive system. CBS expression affects the contents of sulfur-containing metabolites includ...
The Emerging Role of α-Klotho as a Therapeutic Target for Sarcopenia: Underlying Mechanisms and Clinical Prospects [0.03%]
α-klatho在防治肌少症中作用及机制的初步研究
Chen-Chen Sun,Yu-Jie Chen,Jiang-Ling Xiao et al.
Chen-Chen Sun et al.
Sarcopenia is a syndrome characterized by progressive decline in skeletal muscle mass, strength, and physical performance. It has become a common pathological manifestation of aging, physical inactivity, and multiple chronic diseases. The ...
Dual Mechanisms of Chronic Stress in Recurrent Pregnancy Loss: Progesterone Deficiency and Inflammatory Amplification [0.03%]
慢性压力导致反复性自然流产的双重机制：孕酮缺乏和炎症反应增强
Lu Jiang,Xin Yang,Cai Liu et al.
Lu Jiang et al.
Recurrent pregnancy loss (RPL), defined as the loss of two or more pregnancies, is a significant health issue in obstetrics. As a chronic stressor, RPL exerts numerous uncertain effects on pregnancy outcomes. While prior research has recogn...
Francesco Pavan,Sunil Singh Yadav,Andrea Costantino et al.
Francesco Pavan et al.
Background: Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder affecting 5%-10% of the global population and is characterized by recurrent abdominal pain and dysregulation of bowel movements. ...
Metagenomic Profiling of Gut Microbiota in Kidney Precision Medicine Project Participants With CKD and AKI [0.03%]
肾脏精准医学项目受试者CKD和AKI患者的肠道菌群元基因组分析
Sanjeev Noel,Shishir Kumar Patel,James White et al.
Sanjeev Noel et al.
Background: The gut microbiome plays an important role in human health and disease. Kidney Precision Medicine Project (KPMP) is a well-phenotyped, kidney biopsy-proven cohort of AKI and CKD patients. Comprehensive profili...
Lean Mice Exposed to Early Life Stress Exhibit Increased Basal Sympathetic Tone and Blunted Parasympathetic Activation in Response to High Salt Diet [0.03%]
早期生活应激小鼠接触高盐饮食后交感神经张力增加和副交感神经激活减弱
Sundus Ghuneim,Carolina Dalmasso,Meghan B Turner et al.
Sundus Ghuneim et al.
Previously, we showed that male mice subjected to Maternal Separation and Early Weaning (MSEW), a model of early life stress, exhibit heightened cardiovascular responses to hypertensive stimuli. This study aimed to determine whether MSEW in...