Metagenomic Profiling of Gut Microbiota in Kidney Precision Medicine Project Participants With CKD and AKI [0.03%]
肾脏精准医学项目受试者CKD和AKI患者的肠道菌群元基因组分析
Sanjeev Noel,Shishir Kumar Patel,James White et al.
Sanjeev Noel et al.
Background: The gut microbiome plays an important role in human health and disease. Kidney Precision Medicine Project (KPMP) is a well-phenotyped, kidney biopsy-proven cohort of AKI and CKD patients. Comprehensive profili...
Lean Mice Exposed to Early Life Stress Exhibit Increased Basal Sympathetic Tone and Blunted Parasympathetic Activation in Response to High Salt Diet [0.03%]
早期生活应激小鼠接触高盐饮食后交感神经张力增加和副交感神经激活减弱
Sundus Ghuneim,Carolina Dalmasso,Meghan B Turner et al.
Sundus Ghuneim et al.
Previously, we showed that male mice subjected to Maternal Separation and Early Weaning (MSEW), a model of early life stress, exhibit heightened cardiovascular responses to hypertensive stimuli. This study aimed to determine whether MSEW in...
Physiological Mechanisms Vulnerable to Alcohol-Induced Alterations: Role in Chronic Comorbidities [0.03%]
易受酒精诱导改变的生理机制在慢性共病中的作用
Liz Simon,Kaitlin E Couvillion,Meagan E Donovan et al.
Liz Simon et al.
Alcohol misuse is a leading modifiable risk factor for disease burden across the lifespan. Alcohol-mediated end organ injury results from a combination of pathophysiological processes including oxidative stress, mitochondrial dysfunction, c...
Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Physical Fatigue Through the Perspective of Immunosenescence [0.03%]
从免疫衰老的角度理解肌痛性脑脊髓炎/慢性疲劳综合征的物理疲劳
Yingzhe Luo,Huimin Xu,Shaoquan Xiong et al.
Yingzhe Luo et al.
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness marked by persistent fatigue, yet its mechanisms remain unclear. Growing evidence implicates immunosenescence-the age-relat...
Altered Ventilation in Rats With Established Severe Monocrotaline-Induced Pulmonary Hypertension: The Role of the Dorsal Hypothalamus [0.03%]
established severe monocrotaline-induced pulmonary hypertension的受损大鼠的异常通气：背侧下丘脑的作用
Aliaume Le Pape,Christophe Guignabert,Ly Tu et al.
Aliaume Le Pape et al.
Pulmonary hypertension (PH) is a progressive condition characterized by muscularization of precapillary arteries, chronic inflammation, and a loss of the distal pulmonary circulation. These changes can be mimicked in rats by monocrotaline (...
Obesity-Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility [0.03%]
肥胖相关脂肪小体促进血管平滑肌细胞过度收缩
Elsayed Metwally,Imaduddin Mirza,Mohammed H Morsy et al.
Elsayed Metwally et al.
Background: Inter-organ crosstalk, particularly between adipose tissue and vasculature, plays a key role in obesity-induced cardiovascular dysfunction. Our previous work showed that adipose-derived extracellular vesicles ...
SFRP4 Regulates Chondrocyte Hypertrophy and Apoptosis via Wnt/Ca2+ and Wnt/JNK Pathways in Steroid-Induced Osteonecrosis of the Femoral Head [0.03%]
SFRP4通过Wnt/Ca2+和Wnt/JNK途径调节糖皮质激素诱导的股骨头坏死软骨细胞肥大和凋亡
Hongfan Ge,Xiaoli Fan,Yixin Jiang et al.
Hongfan Ge et al.
Abnormal chondrocyte hypertrophy and apoptosis are critical pathological changes in the steroid-induced osteonecrosis of the femoral head (SONFH). The development of SONFH has been strongly linked to the Wingless/Integrated (Wnt) pathway. H...
Obesity Impacts Post-Myocardial Infarction Neovascularization by Downregulating AQP1 Expression via the TRPC5-NFATc3 Signaling Pathway [0.03%]
肥胖通过TRPC5-NFATc3信号通路下调AQP1表达影响心肌梗死后新生血管化
Mengru Gao,Jing Han,Yifei Zhu et al.
Mengru Gao et al.
Obesity is associated with impaired angiogenesis and poor recovery following myocardial infarction (MI), yet the underlying molecular mechanisms remain poorly defined. The transient receptor potential cation channel subfamily C member 5 (TR...
Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System [0.03%]
利用新型多器官芯片系统研究肺和结肠上皮细胞之间的器官间通讯
Brady Rae,Verena Bood,Hye-Jin Dijk et al.
Brady Rae et al.
Chronic Obstructive Pulmonary Disease (COPD), a severe lung disease caused by chronic inhalation of toxic gases and particles, is often accompanied by extrapulmonary comorbidities. These are characterized by systemic inflammation and activa...