Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice [0.03%]
Johannes Burtscher,Robert T Mallet,Anupam Sah et al.
Johannes Burtscher et al.
Hypobaric hypoxia, a defining feature of high-altitude environments, poses a considerable physiological challenge to both humans and rodents. To withstand hypoxic stress, mammals have developed cellular and systemic adaptations that not onl...
Lab, Patients, and Percussion: A Day in the Life of Andreas Herrlich, MD, PhD, Washington University (USA) [0.03%]
Paul Trevorrow,Andreas Herrlich
Paul Trevorrow
Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats [0.03%]
运动和饮食变化对高脂饮食模型大鼠运动协调和氧化标志物的影响
Manuel Jiménez-García,Maria Magdalena Quetglas-Llabrés,Maria Del Mar Ribas-Taberner et al.
Manuel Jiménez-García et al.
Metabolic Associated Fatty Liver Disease (MAFLD) is a prevalent chronic condition with limited therapeutic options, making lifestyle interventions a primary strategy. This study investigated whether exercise, alone or with dietary modificat...
Two Faces of Greater Omentum [0.03%]
大网膜的两面性
Czapiewska Monika,Mika Adriana,Abacjew-Chmylko Anna
Czapiewska Monika
The greater omentum, often described as a "plaster" of the abdominal cavity, exhibits remarkable regenerative and immunological properties. Its unique morphology-rich vasculature and a diverse cellular composition comprising adipocytes, end...
Arun Jose,Hilary M DuBrock,Navneet Singh et al.
Arun Jose et al.
Roles of Diverse Lipokines in Metabolic Homeostasis and Their Associations With Various Diseases [0.03%]
多样脂细胞因子在代谢稳态及各种疾病中的作用及其关联性研究
Chenxuan Liu,Xinyi Zhang,Wenxue Wu et al.
Chenxuan Liu et al.
Lipokines are a class of lipid-derived signaling molecules, playing essential roles in regulating metabolic homeostasis and systemic metabolism. In this review, we first comprehensively describe six major lipokines, including palmitoleic ac...
Cell-Specific Functions of the BAI/ADGRB Subfamily of Adhesion G-Protein Coupled Receptors [0.03%]
BAI/ADGRB亚家族粘附G蛋白偶联受体的细胞特异性功能
Haifa A Alsharif,Sushant Bhatnagar
Haifa A Alsharif
G protein-coupled receptors (GPCRs) are key regulators of various physiological processes and remain the most targeted class of proteins in drug development. Although significant progress has been made in understanding many GPCR families, a...
Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model [0.03%]
非搏动性肺血流量在经典的绵羊Glenn模型中诱导肺血管内皮功能障碍
Jonathan Hyde,Michael A Smith,Naveen Swami et al.
Jonathan Hyde et al.
Background: Pulmonary vascular disease (PVD) in patients with single ventricular heart disease following the partial cavalpulmonary connection (Glenn) is a significant source of morbidity. However, the etiology of pulmona...
Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease [0.03%]
内皮细胞多样性与功能障碍对心血管疾病的影响
Anna E Williams,Luke S Dunaway,Zuzanna J Juśkiewicz et al.
Anna E Williams et al.
Endothelial cells (ECs) are functionally heterogeneous, even in vascular beds within the same organ. As the key cell type lining the vascular lumen, ECs regulate vascular tone (control of blood vessel diameter), permeability of molecules, w...
Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells [0.03%]
BMP/TGF-β信号转导的干扰：人肺微血管内皮细胞中AQP1和TGFB1的调节
Chrysi Keskinidou,Nikolaos S Lotsios,Kostas A Papavassiliou et al.
Chrysi Keskinidou et al.
Pulmonary arterial hypertension (PAH) is a chronic disorder with high fatality rates, and its progression is highly associated with the genetic background. Alongside pathogenic variants in genes central to the BMP/TGF-β signaling pathway, ...