The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function [0.03%]
Daniela Negrini,Eleonora Solari,Cristiana Marcozzi et al.
Daniela Negrini et al.
In thoracic tissues, the lymphatic vasculature not only contributes to fluid and solute homeostasis but also plays a critical role in shaping overall tissue physiology. Although the general morphology of lymphatic vessels and their organiza...
Sharanya S Bettadapura,David C Tangeman,Sushumna B Satyanarayana et al.
Sharanya S Bettadapura et al.
Research to date describes the suprachiasmatic nucleus (SCN) of the hypothalamus as the master pacemaker that synchronizes circadian rhythms in peripheral tissues. However, recent high-impact studies demonstrate that non-SCN tissues can als...
The Glucagonocentric Basis of Diabetic Cardiomyopathy: Pancreas-Heart Crosstalk Linking α-Cell Dysregulation to Cardiac Metabolic Stress and Fibrosis [0.03%]
以高血糖组胺为基础的糖尿病心肌病：胰腺-心脏交叉谈话将α细胞调节异常与心脏代谢压力和纤维化联系起来
Nila Ganamurali,Madhupriya Prabhakaran,Sarvesh Sabarathinam
Nila Ganamurali
Type 2 diabetes mellitus (T2DM) is increasingly recognized as a disorder of inappropriate glucagon secretion in addition to β-cell dysfunction and insulin resistance. Chronic hyperglucagonemia, driven by α-cell dysregulation, contributes ...
Look Who Is Talking: Extracellular Vesicles as Mediators of Intercellular and Interorgan Communication [0.03%]
谁在说话：细胞外囊泡作为细胞间和器官间通讯的介质
Michela Saviana,Giulia Romano,Daniel Del Valle-Morales et al.
Michela Saviana et al.
Extracellular vesicles (EVs) are produced by every organ, serving as vehicles for communication. By circulating throughout the body and targeting both neighboring and distant cells and organs, they can drive downstream signaling. EVs play a...
Glucagon-Like Peptide-2 Receptor: A Master Integrator of Gut-Brain-Liver Communication in Metabolic and Cognitive Health [0.03%]
胰高血糖素样肽-2受体：肠道-大脑-肝脏代谢和认知健康交流的整合器
Yunuo Jiang,Guo Han,Zixu Zhang et al.
Yunuo Jiang et al.
Glucagon-like peptide-2 (GLP-2) has historically been defined by its primary role as an intestinal hormone essential for mucosal growth and epithelial barrier integrity. However, a surge of recent research has sparked a paradigm shift, reca...
Loss of Y Chromosome Associates With Lung and Cardiac Dysfunction in COPD [0.03%]
Y染色体丢失与慢性阻塞性肺疾病患者的肺功能和心功能下降有关
Chanil Valasarajan,Tina Rasper,Jochen Wilhelm et al.
Chanil Valasarajan et al.
This study highlights the previously unknown association of mosaic loss of the Y chromosome to impaired gas exchange and cardiac dysfunction, implicating mosaicism in immune-mediated, multi-organ decline and revealing a mechanistic basis fo...
Navneet Singh,Hilary M DuBrock,Sasha Z Prisco et al.
Navneet Singh et al.
In normal health, the liver and lungs enjoy a close anatomic, physiologic, and functional relationship. In the context of pulmonary vascular disease, however, there is accumulating evidence that the interplay between the gut microbiome, hep...
Duc Huy Hoang Nguyen
Duc Huy Hoang Nguyen
Despite being one of the most densely innervated organs in the thorax, the human heart exhibits a relative insensitivity to chronic visceral pain. Unlike other viscera or enlarging visceral masses of comparable size, progressive mechanical ...
Lactobacillus acidophilus Postbiotics Differentially Modulate Nutrient Sensing, Intestinal Barrier Integrity, and Inflammatory Signaling in Broiler [0.03%]
乳酸菌芽孢杆菌胞外产物通过差异调节营养感应、肠道屏障完整性和炎症信号转导影响 broiler鸡生长性能和免疫功能
Meng Yu,Zhiyun Qin,Atique Ahmed Behan et al.
Meng Yu et al.
The global restriction of antibiotic growth promoters (AGPs) has accelerated the search for sustainable nutritional alternatives that support growth performance and intestinal health of poultry. Postbiotics and their bioactive metabolites d...
Kudret Selin Ozkaya,Kirsteen N Browning
Kudret Selin Ozkaya
Parkinson's disease, characterized by the motor deficits that result from the loss of dopaminergic neurons in the Substantia Nigra pars compacta, is the second most common neurodegenerative disorder worldwide. Parkinson's disease is also co...