Determinants of Abnormal Pulmonary Vasodilatory Response With Exercise in HFpEF: Pulmonary Vascular-Left Atrial Axis Abnormalities [0.03%]
HFpEF运动时异常肺血管扩张反应的决定因素：肺血管-左心房轴异常
Mariana Garcia-Arango,Angela Kristo,Ahmed El Shaer et al.
Mariana Garcia-Arango et al.
Background: Inability to decrease pulmonary vascular resistance (PVR) with exercise may lead to right ventricular failure. In this two-step study, we define an unfavorable exercise PVR response among a broad cohort and th...
Heat Stress-Mediated Multi-Organ Injury: Pathophysiology and Treatment Strategies [0.03%]
热应力介导的多器官损伤：病理生理及治疗策略
Xiaoqing Ding,Binghong Gao
Xiaoqing Ding
With global warming in recent years, humans have been subjected to the impact of thermal environments on both work and life. Improving the body's ability to withstand heat is an urgent task. Accordingly, we summarize the signaling pathways ...
Targeting the Organ-Brain Axis: The Modulatory Role of Peripheral Organs in Depression [0.03%]
靶向器脏-脑轴：外周器官在抑郁症发病中的作用及机制研究进展
Jiayi Han,Wen Zhang,Yuanyuan Zhang et al.
Jiayi Han et al.
Major Depressive Disorder (MDD) is a highly prevalent mental illness whose pathophysiology remains incompletely understood. Although MDD has traditionally been conceptualized primarily as a disorder of central nervous system dysfunction, ac...
The Interstitial Fluid Compartment: Still Unrecognized or Biophysically Well Described? [0.03%]
间隙液 compartment 仍被忽视还是生物物理描述已经很完善？
Daniela Negrini,Giuseppe Miserocchi
Daniela Negrini
The proposal of a "new third bodily system for circulation of fluid" has been recently put forward. The present article sheds light on all available physiological knowledge concerning exactly this same space, defined as "interstitial compar...
The Evolution of Taste: Genetic, Dietary, and Cultural Pathways in Human Taste Perception [0.03%]
味觉的演变：人类味觉感知的遗传、饮食和文化途径
R J Vijayashree,B Sivapathasundharam
R J Vijayashree
Taste perception is an essential sensory system that evolved to guide dietary choices and ensure survival. Human taste arises from the interaction of food-derived chemicals with specialized receptors in taste buds located on lingual papilla...
SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction [0.03%]
糖尿病中的SLIT-ROBO信号：血管生成和血管功能障碍的双重调节因子
Ravichandran Sanjai,Devaprakash Nithya,Kunka Mohanram Ramkumar
Ravichandran Sanjai
Persistent hyperglycemia is a hallmark of diabetes mellitus (DM), a chronic metabolic disease that can lead to peripheral artery disease, retinopathy, nephropathy and other systemic vascular complications. Impaired angiogenesis and compromi...
Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes [0.03%]
心脏特异性脊髓和迷走传入：转录组特征与心肌细胞的功能耦合的光遗传学调控
T Akgul Caglar,Y E Kazci,Z B Durdu et al.
T Akgul Caglar et al.
Sensory neurons innervating the heart transmit chemical and mechanical cues to the central nervous system via the dorsal root ganglion (DRG) and nodose ganglion (NG). Despite their importance in cardiac pain and cardiovascular reflexes, the...
The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure [0.03%]
临床肥胖中的脂肪-器官通讯网络：从脂肪病变为全身代谢衰竭
Sarvesh Sabarathinam
Sarvesh Sabarathinam
The diagnostic landscape of obesity is transitioning from weight centric metrics toward a functional "clinical obesity" framework. This review explores the pathophysiology of adiposopathy ("sick fat"), where hypertrophic adipose tissue trig...
Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure [0.03%]
新型 adiposity 指标与心力衰竭发病的生物关联分析
Yunyao Yang,Jiayong Li,Xixi Xiao et al.
Yunyao Yang et al.
Objective: Obesity is a well-known heart failure (HF) risk factor, yet the biological pathways linking adiposity indices to HF remain unclear. This study aimed to identify proteomic mediators for five novel indices-waist ...
Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential [0.03%]
犬尿酸途径的多米诺效应：系统稳态、代谢互作及潜在治疗作用
Pei-Jun Ma,Yi-Chen Man,Fang-Qing Shen et al.
Pei-Jun Ma et al.
The kynurenine (KYN) pathway (KP) is a central hub in tryptophan (Trp) metabolism, orchestrating immune regulation, neural signaling, and systemic energy homeostasis. Although KP dysregulation has been linked to multiple diseases, a unifyin...