Hepatoblastoma-Derived Exosomal FASN Affected the Differentiation of Hepatic Stellate Cells Into Cancer-Associated Fibroblasts by Regulating the Stability of HK2 and Mediating Histone Lactylation [0.03%]
肝母细胞瘤来源的外泌体FASN通过调控HK2蛋白稳定性及介导组蛋白乳酰化影响HSC向CAFs分化的作用及机制研究
Qin Zhu,Yifan Zhou,Yuyin Wang et al.
Qin Zhu et al.
Cancer-associated fibroblasts (CAFs) interact with tumor cells in the tumor microenvironment (TME), enhancing glycolysis in CAFs and tumor malignancy. However, the regulatory mechanisms between hepatoblastoma (HB) cells and CAFs are unclear...
Gut Microbiota in Rheumatoid Arthritis: Unraveling Pathogenic Mechanisms and Therapeutic Opportunities [0.03%]
肠道微生物群和类风湿关节炎：揭示病理机制和治疗机会
Yang Yun,Guo-Qiang Xu,Xiao-Jing Jiang et al.
Yang Yun et al.
Rheumatoid arthritis (RA), a chronic autoimmune disorder driven by genetic-environmental interplay, manifests as progressive synovitis and irreversible joint damage. Despite mechanistic advances in disease-modifying antirheumatic drugs (DMA...
Identification of an Intracellular Role for Complement Factor D: Lipid Droplet Biogenesis in Differentiating Adipocytes [0.03%]
补体因子D的胞内作用鉴定：在分化脂肪细胞中生成脂滴的作用
Behnoush Khaledian,Kazutsune Yamagata,Takuya Kato et al.
Behnoush Khaledian et al.
Complement factor D (CFD, also known as adipsin) is a secreted serine protease classically known for activating the alternative complement pathway and regulating systemic metabolism. Although CFD is highly expressed in adipocytes, its roles...
Beyond Structure: The Interplay of Bone and Brain During Alzheimer's Disease [0.03%]
超越结构：阿尔茨海默病期间骨与脑的相互作用
Ananya Pinnamaneni,Anika Akkiraju,Hannah I Park et al.
Ananya Pinnamaneni et al.
Alzheimer's disease (AD), a leading cause of dementia in the elderly, is traditionally characterized by neurodegeneration driven by amyloid-beta plaques and tau tangles. However, emerging evidence reveals that AD's impact extends beyond the...
Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice [0.03%]
人类、大鼠和小鼠低氧反应及高原适应的生理学差异机制研究进展
Johannes Burtscher,Robert T Mallet,Anupam Sah et al.
Johannes Burtscher et al.
Hypobaric hypoxia, a defining feature of high-altitude environments, poses a considerable physiological challenge to both humans and rodents. To withstand hypoxic stress, mammals have developed cellular and systemic adaptations that not onl...
Lab, Patients, and Percussion: A Day in the Life of Andreas Herrlich, MD, PhD, Washington University (USA) [0.03%]
实验室、患者和叩诊声：Andreas Herrlich医生的一天（美国华盛顿大学）
Paul Trevorrow,Andreas Herrlich
Paul Trevorrow
Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High-Fat Diet Model in Rats [0.03%]
运动和饮食变化对高脂饮食模型大鼠运动协调和氧化标志物的影响
Manuel Jiménez-García,Maria Magdalena Quetglas-Llabrés,Maria Del Mar Ribas-Taberner et al.
Manuel Jiménez-García et al.
Metabolic Associated Fatty Liver Disease (MAFLD) is a prevalent chronic condition with limited therapeutic options, making lifestyle interventions a primary strategy. This study investigated whether exercise, alone or with dietary modificat...
Two Faces of Greater Omentum [0.03%]
大网膜的两面性
Czapiewska Monika,Mika Adriana,Abacjew-Chmylko Anna
Czapiewska Monika
The greater omentum, often described as a "plaster" of the abdominal cavity, exhibits remarkable regenerative and immunological properties. Its unique morphology-rich vasculature and a diverse cellular composition comprising adipocytes, end...
Arun Jose,Hilary M DuBrock,Navneet Singh et al.
Arun Jose et al.
Roles of Diverse Lipokines in Metabolic Homeostasis and Their Associations With Various Diseases [0.03%]
多样脂细胞因子在代谢稳态及各种疾病中的作用及其关联性研究
Chenxuan Liu,Xinyi Zhang,Wenxue Wu et al.
Chenxuan Liu et al.
Lipokines are a class of lipid-derived signaling molecules, playing essential roles in regulating metabolic homeostasis and systemic metabolism. In this review, we first comprehensively describe six major lipokines, including palmitoleic ac...