Gut Microbiota in Pulmonary Arterial Hypertension: Murine Models and Human Microbial Signatures, Pathogenic Mechanisms, and Emerging Therapeutic Avenues [0.03%]
肺动脉高压中的肠道微生物群：小鼠模型与人类微生物特征、发病机制和新兴治疗途径
Yudan Qiu,Xiaojiang Lyu,Dashuang Zhang et al.
Yudan Qiu et al.
Pulmonary arterial hypertension (PAH) is a chronic, severe cardiopulmonary disease characterized by the progressive increase in pulmonary vascular resistance (PVR) because of the proliferation and fibrosis of the pulmonary arterioles. Altho...
Protective Effect and Mechanism of Short-Chain Fatty Acids, the Metabolites of Gut Microbiota, on Atrial Fibrillation [0.03%]
肠道微生物代谢产物短链脂肪酸对房颤保护作用及机制研究
Wen-Lu Ren,Zhong-Wei Yao,Xiang-Wei Ding et al.
Wen-Lu Ren et al.
Atrial fibrillation (AF) is one of the most common arrhythmias with complex pathogenesis. Recent studies showed that gut microbiota and its metabolic products, especially short-chain fatty acids (SCFAs), are closely linked to the onset and ...
Metabolomic Markers and Pathways of Blood-Brain Barrier Damage: A Systematic Review [0.03%]
血脑屏障损伤的代谢标志物和途径：系统评价
Andrzej Wasilewski,Agata Serrafi,Igor Działak et al.
Andrzej Wasilewski et al.
Objectives: This study aimed to identify metabolites and metabolic pathways associated with blood-brain barrier (BBB) dysfunction in human and animal metabolomic research. ...
Interconnected Organs: Exploring the Impact of Kidney-Lung Crosstalk in Critically Ill Neonates and Children [0.03%]
相互关联的器官：探索危重新生儿和儿童肾肺交互作用的影响
Michelle C Starr,Stephen Gorga,Katja M Gist
Michelle C Starr
Acute kidney injury (AKI) and acute lung injury (ALI) are common in critically ill neonates, children, and those with severe cardiac disease. Although kidney and lung dysfunction can occur independently, molecular signaling and organ crosst...
Interorgan Communication-Pulmonary Vein Stenosis in Children-A Review of Epidemiology, Pathophysiology, and Current Management Principles [0.03%]
器官间通讯-儿童肺静脉狭窄的流行病学、病理生理和当前管理原则的综述
Usha S Krishnan,Mary P Mullen
Usha S Krishnan
Understanding communication between various organ systems is vital to understanding the pathophysiology of disease, and this assists in tailoring appropriate therapies. Pulmonary vein stenosis is an example of a multi-organ disease process ...
Advantage of Semaglutide: Comprehensive Analysis of Metabolic Impact of Semaglutide-Treated and Pair-Fed Rats [0.03%]
索马鲁肽的优势：索马鲁肽治疗与配对喂养大鼠的代谢影响的全面分析
Suyeun Byun,Morgan R Sotzen,Mya A Knappenberger et al.
Suyeun Byun et al.
Semaglutide (SEMA), a GLP-1 receptor agonist, effectively reduces body weight. Yet its mechanisms of action remain incompletely understood. It is unclear whether SEMA promotes weight loss solely through reduced food intake or also through i...
Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions [0.03%]
胰岛素加速和延缓衰老：从分子图谱到临床干预
Shi-Cheng Chen,Xiao-Dong Sun,Yuan-Yuan Zhang
Shi-Cheng Chen
Population aging poses a significant threat to quality of life and contributes to an increasing medical burden. The concept of healthy aging has emerged to represent an aging process that is relatively well controlled. However, due to the m...
Geltrex-Enhanced Two-Dimensional Culture as a Viable Alternative to Primary Rat Hepatocyte Sandwich Models [0.03%]
一种改进的二维细胞培养体系作为初级大鼠肝细胞 sandwich 模型的可选方案
Eda Beldek,Matilda Holtz,Adil Denizli et al.
Eda Beldek et al.
Primary hepatocytes rapidly lose viability and function in conventional two-dimensional (2D) cultures due to the absence of a physiologically relevant extracellular matrix (ECM). The collagen sandwich method improves polarization and functi...
Organ Crosstalk During Injury: Mechanisms of Lung-Kidney Interaction in Critical Illness [0.03%]
损伤情况下的器官相互作用：危重症状态下的肺-肾交互机制
Kathryn M Sullivan,Kathleen D Liu,Michael A Matthay
Kathryn M Sullivan
The kidneys and lungs are frequent sites of organ injury during critical illness. Acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) are clinical syndromes resulting from kidney and lung injury respectively. Complex pa...
Renal Medullary but Not Cerebral Hypoxia in a Large Animal Model of Heart Failure With Mildly Reduced Ejection Fraction [0.03%]
大型心脏衰竭动物模型的肾髓质缺氧（射血分数轻度降低）但不是脑缺氧
Anton L Trask-Marino,Lachlan F Miles,Terase F Lancefield et al.
Anton L Trask-Marino et al.
Background: Chronic kidney disease and cognitive impairment are common in heart failure, but how changes in microcirculatory perfusion and oxygenation contribute to these complications remains unclear. We investigated how...