The Integrated Stress Response in Cancer: Paradox and Therapeutic Promise [0.03%]
癌症中的综合应力反应：矛盾与治疗前景
Chenliang Zhang,Ting Zhang,Qiulin Tang et al.
Chenliang Zhang et al.
The integrated stress response (ISR) is an evolutionarily conserved signaling pathway that converges diverse cellular stresses onto the eIF2α-ATF4 axis, thereby orchestrating a fundamental decision between adaptive survival and cell death....
Rauchelle E Richey,Robert D Hyldahl,Brendan W Kaiser et al.
Rauchelle E Richey et al.
Heat therapy is a historic modality that has been used as a source of lifestyle intervention and community for many different cultures. Over the last ~40 years, heat therapy has gained increasing popularity among scientists and clinicians a...
The Microbiota-Gut-Brain Axis in the Pathophysiology of Major Depressive Disorder: A Mechanistic Review [0.03%]
抑郁症发病机制的微菌群-肠道-大脑轴研究：综述各类影响因素及作用机制
Adnan Akif,Md Rabiul Islam
Adnan Akif
Major Depressive Disorder (MDD) is a globally prevalent and debilitating psychiatric condition whose pathophysiology remains incompletely understood. Emerging evidence compels a paradigm shift from a purely neurocentric model to one that in...
Immunosenescence-Driven Hemodynamic Dysregulation and Cognitive Impairment in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Integrative Perspective [0.03%]
肌痛性脑脊髓炎/慢性疲劳综合征中的免疫衰老驱动的血流动力学紊乱和认知障碍：整合视角
Huimin Xu,Yingzhe Luo,Xi Wu
Huimin Xu
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder marked by persistent fatigue and cognitive impairments, often termed "brain fog." Emerging evidence suggests that immunosenescence, age- or stress-related det...
Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss [0.03%]
早老素L166P突变（家族性阿尔茨海默病模型）导致早期骨量丢失
Vidyani Suryadevara,Connor J Krehbial,Anuradha K Valiya et al.
Vidyani Suryadevara et al.
Accelerated bone loss has been reported in the early stages of Alzheimer's disease (AD) as indicated by reduced bone mineral density and increased fracture risk in these patients, compared to healthy individuals. In the present study, we in...
Inhaled Halogen-Induced Oxidative Renal Damage and Dysfunction: A Lung Heart Kidney Axis [0.03%]
吸入卤素引起的氧化性肾损伤和肾功能障碍：肺心肾轴的作用
Juan Xavier Masjoan Juncos,Ahmed Zaky,Wesam Nasser et al.
Juan Xavier Masjoan Juncos et al.
Acute exposure to halogen gases causes extensive injury to the lungs and heart that may be fatal. To evaluate secondary renal complications subsequent to pulmonary and cardiac dysfunction, rats were exposed to bromine and chlorine, and thei...
The Impact of High-Intensity Exercise in Normobaric Hypoxia on Right Ventricular Function in Trained and Untrained Men-An Echocardiographic Study [0.03%]
normobaric缺氧高强度运动对训练和未训练男性右心室功能的影响-超声心动图研究
Gajda Robert,Czuba Miłosz,Płoszczyca Kamila et al.
Gajda Robert et al.
Acute exposure to hypoxia affects the cardiovascular system, especially pulmonary circulation and right heart hemodynamics. However, the impact of normobaric hypoxia on the right heart chambers during exercise is still not clear. This study...
Randomized Controlled Trial
Comprehensive Physiology. 2026 Feb;16(1):e70090. DOI:10.1002/cph4.70090 2026
A Design for Research: A Day in the Life of Jana Grune, Unverstatsmedizin Berlin, Germany [0.03%]
德国柏林大学医学中心的一天：扬娜博士的研究生活设计之日志
Jana Grune,Paul Trevorrow
Jana Grune
Micro-Nano Plastics and 6-PPD-Q in Cardio-Pulmonary Health: Environmental Sources, Systemic Exposure, and Mechanistic Insights [0.03%]
微纳米塑料和6-PPD-Q在心肺健康中的作用：环境来源、全身暴露及机制研究
Kunal Sikder,Pravesh Sharma,Jyoti Varma et al.
Kunal Sikder et al.
Micro- and nanoplastics (MNPs) and the tire-derived transformation product 6-PPD-Quinone (6-PPD-Q) have emerged as pervasive environmental pollutants with critical implications for cardiopulmonary health and ecosystem integrity. This review...
Red Blood Cell Glycation Triggers In Vivo Cerebral Erythrophagocytosis in Adult Zebrafish in a Model Mimicking Hemorrhagic Stroke [0.03%]
糖基化红细胞触发成人斑马鱼出血性卒中模型中的脑内吞作用
Elena Morello,Philippe Rondeau,François Canonne-Hergaux et al.
Elena Morello et al.
Hemorrhagic stroke, particularly intracerebral hemorrhage (ICH), is a highly lethal subtype of stroke, responsible for a poor prognosis and a high rate of disability. ICH is characterized by the extravasation of red blood cells (RBCs) into ...