The Temporal Effects of Hyperbaric Oxygen Intervention on Heart Rate Variability in Young Adults [0.03%]
高压氧干预对于年轻成人的心率变异性的影响研究
Hongyang Zhang,Hao Liu,Zhu Huang et al.
Hongyang Zhang et al.
Objective: This prospective cohort study aimed to investigate the temporal effects and additional characteristics of hyperbaric oxygen (HBO) intervention on heart rate variability (HRV) and autonomic nervous system (ANS) ...
Dynamic Modulation of the Gut Microbiome in Neurodegenerative Diseases: Mechanisms, Therapeutic Potential, and Clinical Perspective [0.03%]
神经退行性疾病中肠道菌群的动态调节：机制、治疗潜力和临床展望
Shilpa Devi,Nabendu Debnath,Pooja Yadav et al.
Shilpa Devi et al.
The gut and brain communicate bidirectionally through the gut microbiota, forming a complex network often referred to as the "microbiota-gut-brain axis." The gastrointestinal microbiome produces various metabolites, including short-chain fa...
Glycolytic Signaling Pathways and Anti-Glycolytic Therapy for Cancer: Research and Perspectives [0.03%]
癌症的糖酵解信号通路和抗糖酵解治疗：研究与展望
Xiang Li,Siqi Li,Dingding Li et al.
Xiang Li et al.
The Warburg effect refers to a metabolic reprogramming process characterized by enhanced glycolysis and lactate production, even in the presence of adequate oxygen. This phenomenon is a critical adaptation enabling tumor cells to satisfy th...
Evaluating Anesthetics for Improving Scientific Research and Welfare Using Larval Zebrafish [0.03%]
利用斑马鱼幼虫评估麻醉剂以改进科学研究和福利
Sylvia Dimitriadou,Mhairi Miller,Ali Pilehvar et al.
Sylvia Dimitriadou et al.
Establishing anesthesia for ensuring both animal welfare and compatibility with protocols required for different areas of scientific research is vital. Zebrafish (Danio rerio) are one of the most used animal models in research; however, lit...
The Acyltransferase Transmembrane Protein 68 Promotes Neutral Lipid Storage in Mouse Adipocytes [0.03%]
酰基转移酶跨膜蛋白68促进小鼠脂肪细胞中中性脂质的储存
Tingting Li,Christoph Heier,Chunyan Zhang et al.
Tingting Li et al.
Transmembrane protein 68 (TMEM68) is a recently identified TAG synthase that is highly expressed in the brain and regulates central nervous lipid homeostasis. The global deficiency of TMEM68 in mice causes reduced adipose tissue mass indica...
Navneet Singh,Jordan Lawson,Ashok Ragavendran et al.
Navneet Singh et al.
The liver's contribution to pulmonary arterial hypertension (PAH) pathogenesis remains unclear. We hypothesized that the liver promotes inflammatory injury to the pulmonary endothelium. PAH patients without liver disease with pulmonary arte...
Heart-Lung Interactions in Pulmonary Hypertension due to Heart Failure With Preserved Ejection Fraction [0.03%]
射血分数保留的心力衰竭所致肺动脉高压的心肺相互作用
Pratima Prabala,Farhan Raza,Naomi C Chesler
Pratima Prabala
Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is a common and high-risk clinical condition characterized by the convergence of pulmonary vascular dysfunction and right ventricular (RV) stre...
MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression [0.03%]
微RNA-21-5p通过减弱缺氧诱导因子的反应和改变基因表达来保护发育期缺氧时胚胎生长和心脏功能
Bernardo J Krause,Ximena Calle,Ranya V Kumar et al.
Bernardo J Krause et al.
Fetal hypoxia is a common complication of pregnancy and increases the cardiovascular risk in offspring, contributing to a significant burden on life-long health. Preventative strategies against its adverse effects have focused on targeting ...
GDNF Maintains Mitochondrial Homeostasis and Inhibits Ferroptosis to Improve Osteogenic Function in Osteoporosis [0.03%]
GDNF通过维持线粒体稳态和抑制铁死亡改善骨质疏松症成骨功能
Yafei Zhu,Runhan Zhao,Yingtao Duan et al.
Yafei Zhu et al.
Osteoporosis is a metabolic bone disease characterized by reduced bone mass and deterioration of bone microarchitecture, in which impaired osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) represents a central...
Vascularization Is Driven by Sprouting and Subsequent Splitting: Mechanisms of Physiological Angiogenesis in a Porous Biomaterial Scaffold and Intervention Insights [0.03%]
血管生成由出芽驱动，并随后发生分裂：多孔生物材料支架中生理血管生成的机制及干预启示
Kuihua Zhan,Lun Bai
Kuihua Zhan
Vascularization is a prerequisite for the in vivo survival of tissue engineering constructs, especially large-scale ones. However, due to inadequate research on the underlying mechanisms of physiological angiogenesis in biomaterials, the ab...