The Vascular-Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension [0.03%]
肺动脉高压中的血管免疫细胞交叉-talk及微环境
Lola Navarro-Llinares,Bertha García-León,Laura de la Bastida-Casero et al.
Lola Navarro-Llinares et al.
Pulmonary hypertension is a disease of the lung vasculature, which eventually leads to heart dysfunction. Despite the advances in the discovery and development of new treatments, most of them are aimed to palliate symptoms. Thus, it is cruc...
Hypothalamic-Pituitary-Thyroid and Adrenal Axis Modulation in Response to Fetal Porcine Reproductive and Respiratory Virus Infection [0.03%]
猪繁殖与呼吸综合征病毒对下丘脑-垂体-甲状腺和肾上腺轴的调节响应机制
Alyssa A Smith,Glenn Hamonic,Graham S Plastow et al.
Alyssa A Smith et al.
Porcine reproductive and respiratory virus (PRRSV) has been shown to cause a substantial decrease in circulating thyroid hormone levels, consistent with nonthyroidal illness syndrome (NTIS) observed in response to other nidoviruses. This ef...
Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension [0.03%]
可溶性环氧水合酶磷atase活性失活调节SIRT3并减轻实验性肺高血压
Matthieu Leuillier,Mustapha Chelgham,Hind Messaoudi et al.
Matthieu Leuillier et al.
Introduction: Pulmonary hypertension (PH) is a severe cardiovascular disorder characterized by elevated pulmonary artery pressure caused by remodeling of the pulmonary circulation. This study aimed to investigate the role...
ATGL From iWAT and BAT Is Crucial for Cardiac Remodeling and Metabolism After Myocardial Ischemia/Reperfusion [0.03%]
肠系膜前部白色脂肪组织和褐色脂肪组织中的ATGL在心肌缺血再灌注后的心脏重塑及代谢中起关键作用
Heba Zabri,Alisa Ucar,Luzhou Wang et al.
Heba Zabri et al.
Adipose tissue ATGL has emerged as an important player in cardiovascular disease. Myocardial infarction is accompanied by sympathetic stimulation and activation of white adipose tissue and peripheral lipolysis. We therefore investigate here...
The Curious Investigator-A Day in the Life of Ilia Droujinine, PhD, Scripps Research Institute (USA) [0.03%]
饶有兴致的调查者——伊利亚·德鲁金博士的一天（斯克利普斯研究所，美国）
Ilia Droujinine,Paul Trevorrow
Ilia Droujinine
Molecular Signatures of Preeclampsia: The Role of Post-Translational Protein Modifications [0.03%]
子痫前期的分子特征：蛋白质翻译后修饰的作用
Sarah G Rodrigues,Karine A Assis,João Lucas M Silva et al.
Sarah G Rodrigues et al.
Preeclampsia (PE) is a complex hypertensive disorder of pregnancy characterized by placental dysfunction, systemic inflammation, oxidative stress, and widespread maternal endothelial injury. Although multiple molecular pathways have been im...
Molecular Mechanisms and Therapeutic Potential of DJ-1 in Skeletal Muscle Homeostasis and Disease [0.03%]
分子机制和DJ-1在骨骼肌稳态和疾病治疗潜力中的作用
Yue Zhang,Menghuan Li,Xiaojing Xie et al.
Yue Zhang et al.
The DJ-1 protein was initially identified as an oncogene, but subsequent studies revealed its crucial protective role in neurodegenerative diseases. Increasing evidence indicates that DJ-1 possesses critical physiological functions in skele...
Patient-Specific Lumped-Parameter Model for Quantifying Vessel-Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension [0.03%]
基于患者的参数模型量化肺动脉高压血管重塑和预测右心室功能
Christopher G Lechuga,Amirreza Kachabi,Mitchel J Colebank et al.
Christopher G Lechuga et al.
Purpose: Pulmonary hypertension (PH) is a heterogeneous disease with patient-specific variability and vessel-specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessmen...
Seungseo Choi,Laura A Dada,Jacob I Sznajder
Seungseo Choi
The biological effects of hypercapnia on the lungs have been controversial. Earlier publications suggesting that hypercapnia was beneficial for mechanically ventilated patients with acute lung injury led to the clinical paradigm of "permiss...
Vildagliptin and Omarigliptin Differentially Bind to DPP-4 Homodimers and Modulate Osteoclast-Mediated Bone Resorption [0.03%]
维格列汀和奥马列吉普汀与DPP-4同源二聚体结合并调节破骨细胞介导的骨吸收作用机制不同
Ratchaneevan Aeimlapa,Jiraporn Panmanee,Jarinthorn Teerapornpuntakit et al.
Ratchaneevan Aeimlapa et al.
Increased fracture risk in prediabetes and diabetes mellitus partly arises from bone collagen damage and enhanced bone resorption. Certain antidiabetic agents-particularly thiazolidinediones-paradoxically aggravate bone loss and fractures, ...