Influence of Exercise Heat Acclimation Protocol Characteristics on Adaptation Kinetics: A Quantitative Review With Bayesian Meta-Regressions [0.03%]
锻炼热适应方案特征对适应动力学影响的定量审查与贝叶斯元回归分析
Peter McDonald,Harry A Brown,Thomas H Topham et al.
Peter McDonald et al.
The integrative influence of heat acclimation (HA) protocol characteristics and approach on adaptation kinetics and exercise capacity/performance in the heat remains unclear. Bayesian multilevel regression models were used to estimate adapt...
Towards a Better Understanding of Heart-Lung Interactions in Pulmonary Vascular Disease [0.03%]
探究肺血管疾病中心肺相互作用的机制
Tim Lahm,Erika Berman-Rosenzweig,Naomi C Chesler et al.
Tim Lahm et al.
Specific Adaptive Mechanisms in Water-Sodium Regulation in a Desert Rodent Fed With Salty Diets [0.03%]
食盐的沙漠啮齿动物水钠调节的适应性机制
Xin-Zhi Yang,Chen-Zhu Wang,De-Hua Wang et al.
Xin-Zhi Yang et al.
High-salt diets (HSD) are known to cause renal injury and hypertension in mice, rats, or even humans. Desert rodents have evolved an ability to adapt to water scarcity and concentrated electrolytes in vegetation over a long evolutionary per...
Jinping Shen,Yuling Jiang,Wenxia Bu et al.
Jinping Shen et al.
Pulmonary fibrosis (PF) is a chronic, progressive fibrotic interstitial lung disease characterized by a high incidence and mortality rate, which encompasses features, such as diffuse alveolar inflammation, invasive fibroblast activation, an...
Leptin and Associated Neural Pathways Underlying Obesity-Induced Hypertension [0.03%]
肥胖引起的高血压相关的瘦素及神经通路研究进展
Connor Laule,Kamal Rahmouni
Connor Laule
Obesity rates have surged to pandemic levels, placing tremendous burden on our society. This chronic and complex disease is related to the development of many life-threatening illnesses including cardiovascular diseases. Hypertension caused...
Tet Methylcytosine Dioxygenase 2 (TET2) Mutation Drives a Global Hypermethylation Signature in Patients With Pulmonary Arterial Hypertension (PAH): Correlation With Altered Gene Expression Relevant to a Common T Cell Phenotype [0.03%]
肺动脉高压患者的Tet甲基胞嘧啶二氧酶2（TET2）突变导致全基因组高甲基化：与常见T细胞表型相关的基因表达改变相关性研究
Charles C T Hindmarch,François Potus,Ruaa Al-Qazazi et al.
Charles C T Hindmarch et al.
Epigenetic changes in gene expression due to DNA methylation regulate pulmonary vascular structure and function. Genetic or acquired alterations in DNA methylation/demethylation can promote the development of pulmonary arterial hypertension...
Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond [0.03%]
支配摄食-饱腹感等生理活动的迷走神经感觉通路
Rebeca Mendez-Hernandez,Isadora Braga,Avnika Bali et al.
Rebeca Mendez-Hernandez et al.
The vagus nerve is the body's primary sensory conduit from gut to brain, traditionally viewed as a passive relay for satiety signals. However, emerging evidence reveals a far more complex system-one that actively encodes diverse aspects of ...
Sex and Depot Specific Adipocyte Proteome Profiling In Vivo via Intracellular Proximity Labeling [0.03%]
体内通过细胞内近距离标记进行的性別和脂肪特异性脂肪细胞蛋白质组谱分析
Taylor L Simonian,Amanda S Meyer,Jinjin Guo et al.
Taylor L Simonian et al.
Adipose tissue has varying distributions and metabolic properties between the sexes. Inherent sex-specific differences in adipocytes may heighten the risk of metabolic disease in males. Analysis of the adipocyte proteome can potentially pro...
Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis Through the Gut-Neuron Axis [0.03%]
雷洛昔芬和丁酸钠通过肠神经轴对肌萎缩侧索硬化症屏障功能和疾病进展的协同作用
Yongguo Zhang,KaReisha Robinson,Yinglin Xia et al.
Yongguo Zhang et al.
Emerging evidence has shown that gut-brain barrier dysfunction occurs at the early stages of ALS. Previous studies demonstrated that sodium butyrate significantly prolonged the life span of ALS mice. Riluzole is the first FDA-approved drug ...