Porcine Fetal Hypothyroidism Induces Temporal and Tissue-Specific Alterations in the Insulin-Like Growth Factor System [0.03%]
低甲状腺素诱导胰岛素样生长因子系统的时间和组织特异性改变
Alyssa A Smith,J Alex Pasternak
Alyssa A Smith
To characterize the interaction between the fetal thyroid and IGF system, we utilized a temporal model of porcine fetal hypothyroidism. N = 24 pregnant gilts were split into two treatment groups, with 12 gilts receiving a daily oral dose of...
Alice Huertas,Jahar Bhattacharya
Alice Huertas
Leptin, an adipokine primarily produced in white adipose tissue, plays a crucial role in metabolism, immunity, and inflammation. Originally identified as a satiety hormone, leptin is also synthesized in various tissues, including the lungs,...
Hepatic Cytochrome P450 Enzymatic System Interaction With Platelet Function and Cardiovascular Outcomes-Pharmacogenomic Impact on Inter-Organ Communication [0.03%]
肝细胞色素P450酶系统与血小板功能和心血管结局的相互作用-药理基因组学对器官间通讯的影响
Marta Figueiral,Abdullah Al-Abcha,Matteo Castrichini et al.
Marta Figueiral et al.
Platelets are small, anucleate particles derived from bone marrow megakaryocytes that circulate in the blood and are central to hemostasis, atherothrombosis, and post-angioplasty coronary restenosis. Initially thought to involve a simple pr...
Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD) [0.03%]
白三烯：连接哮喘和炎症性肠病(IBD)的炎症缺口
Emma Elizabeth Sabu Kattuman,Lakshminarayan Reddy Teegala,Somayeh Darzi et al.
Emma Elizabeth Sabu Kattuman et al.
Leukotrienes are potent inflammatory lipid mediators produced primarily by immune cells. Inflammation, being the center stone of two major disease conditions, namely, asthma and inflammatory bowel disease (IBD), has led researchers to study...
Microbiota in Gut-Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease [0.03%]
肠道-心脏轴中的微生物群：心血管疾病中的代谢物和机制
Narendra Kondapalli,Venkatesh Katari,Kesha K Dalal et al.
Narendra Kondapalli et al.
Emerging evidence highlights the pivotal role of gut microbiota in regulating cardiovascular health and disease. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, interacts with its host throu...
Lysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis [0.03%]
溶酶体酸化：肺纤维病发病机制及治疗的新视角
Kai Tian,Mengjiao Yu,Mengna Jiang et al.
Kai Tian et al.
Pulmonary fibrosis is a complex pathophysiological process characterized by local pulmonary inflammation and fibrosis, along with systemic inflammation and distal organ damage. The acidic environment of lysosomes, as intracellular degradati...
Kidney-Heart-Lung Interorgan Communication Networks in Health and Disease [0.03%]
健康与疾病状态下的肾-心-肺器官间通信网络
Andreas Herrlich,Jana Grune,Wolfgang M Kuebler
Andreas Herrlich
Maternal Nutritional Environment and the Development of the Melanocortin System [0.03%]
母体营养环境与黑素皮质素系统发育的关系
Marina Galleazzo Martins,Alfonso Abizaid
Marina Galleazzo Martins
The maternal nutritional and/or metabolic environment is crucial for future offspring health outcomes, and impairments during critical periods of development can alter the development of brain circuits that regulate energy balance, predispo...
Mechanistic Insights Into Long Covid: Viral Persistence, Immune Dysregulation, and Multi-Organ Dysfunction [0.03%]
长新冠的机制见解：病毒持续存在、免疫失调和多器官功能障碍
Gautam Gupta,Danilo Buonsenso,John Wood et al.
Gautam Gupta et al.
Long Covid is a post-viral syndrome characterized by persistent symptoms targeting multiple organ systems after initial SARS-CoV-2 infection. Current literature suggests that the mechanisms causing Long Covid involve viral persistence, immu...
Adipose Tissue-Derived Adipokines in Vascular Physiology and Pathophysiology: Insights and Implications [0.03%]
血管生理和病理生理中的脂肪组织源性脂肪细胞因子：见解与影响
Ariane Bruder,Thiago Bruder-Nascimento
Ariane Bruder
Adipose tissue serves not only as a storage organ but also plays an active role in maintaining the body's homeostasis as an endocrine component. Mainly made up of adipocytes that store energy as triglyceride droplets, this tissue also conta...