Inhaled 5-HT1B /1D Receptor Antagonist Attenuates Sumatriptan-Induced Sensitization of Capsaicin-Sensitive Lung Vagal Afferents: Implications for Preventing Sumatriptan-Associated Adverse Chest Symptoms [0.03%]
吸入型5-HT1B / 1D受体拮抗剂可减轻右美式三嗪诱导的辣椒素敏感肺迷走神经传入敏化：预防舒马曲坦相关不良胸部症状的意义
Nai-Ju Chan,Zung Fan Yuan,Chang-Chih Kuo et al.
Nai-Ju Chan et al.
Background: Sumatriptan, an antimigraine drug, is known to cause adverse chest symptoms such as dyspnea and chest tightness. We previously showed that sumatriptan sensitized capsaicin-sensitive lung vagal (CSLV) afferents...
Gaston van Hassel,Jozine M Ter Maaten,Iris E Beldhuis et al.
Gaston van Hassel et al.
Background: Kidney dysfunction is prevalent but insufficiently understood in Fontan patients. We aimed to investigate Fontan-Associated Renal Disease (FARD) through comprehensive phenotyping using biomarkers of renal func...
Elizabeth G Mietlicki-Baase
Elizabeth G Mietlicki-Baase
Obesity is a disease that is both costly and prevalent, and although the development and use of glucagon-like peptide-1 receptor agonists has dramatically altered the landscape of obesity treatment, there remains a need to identify alternat...
Molecular Mechanisms of Lipid-Modifying Enzymes in Cellular Adaptation and Systemic Glucose Homeostasis [0.03%]
细胞适应和全身葡萄糖稳态中的脂质修饰酶的分子机制
Nila Ganamurali,Sarvesh Sabarathinam,Navodi Sandamini Jayathilaka et al.
Nila Ganamurali et al.
Lipid-modifying enzymes dynamically regulate membrane architecture, signaling compartmentalization, and inter-organ metabolic communication, thereby influencing systemic glucose homeostasis. Advances in lipidomics and structural enzymology ...
A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action [0.03%]
迷走神经刺激治疗疾病的综述：作用机制的全面理论和证据评估
Yifeng Bu,Alex Liang,Benjamin U Hoffman et al.
Yifeng Bu et al.
Vagus nerve stimulation (VNS) is an established neuromodulatory therapy approved for epilepsy, depression, obesity, stroke rehabilitation, rheumatoid arthritis, migraine, and cluster headaches. Its therapeutic potential has expanded dramati...
Organizing the Chaos: A Day in the Life of Brant Isakson, University of Virginia, USA [0.03%]
乱中求序：美国弗吉尼亚大学布兰特•艾萨克斯的一天
Paul Trevorrow,Brant Isakson
Paul Trevorrow
SLC and ABC Transporters in Lung Cancer: Orchestrators of Malignancy and Therapeutic Resistance [0.03%]
肺癌中的SLC和ABC转运蛋白：恶性转化和治疗耐药性的调控者
Ping Li,Minlei Dong,Binxin Chen et al.
Ping Li et al.
Background: Lung cancer remains a leading cause of global cancer mortality, with therapeutic efficacy significantly hampered by intrinsic and acquired therapy resistance. Solute carrier (SLC) and ATP-binding cassette (ABC...
Prostaglandin E2-EP4 Signaling at the Gut-Immune-Metabolic Interface: A Lipid Mediator Perspective on Obesity and Insulin Resistance [0.03%]
肠道免疫代谢界面的前列腺素E2-EP4信号：肥胖和胰岛素抵抗的脂质介质观点
Nila Ganamurali,Sarvesh Sabarathinam
Nila Ganamurali
Despite advances in dietary and pharmacologic therapies, obesity rates continue to escalate globally. Emerging evidence implicates the gut-immune interface as a key determinant of metabolic dysfunction. This review highlights the prostaglan...
Kisspeptin Neurons as Integrative Hub: Cross-Talk of HPO-HPT-HPA Axes in Perimenopausal Reproductive Health [0.03%]
亲吻肽神经元作为整合中心：围绝经期生殖健康中HPO-HPT-HPA轴的相互作用
Yujie Xu,Han Wu,Ru Mu et al.
Yujie Xu et al.
This study methodically examines the mechanisms of interaction of these neuroendocrine axes in perimenopausal women and their overall effects on their reproductive health. The results show that the dysfunction of the HPT axis is closely rel...
The Role of G Protein-Coupled Receptors in Aging and the Modulatory Impact of Physical Activity: A Systematic Review [0.03%]
G蛋白偶联受体在衰老中的作用以及体力活动的调节影响：系统性综述
Nasrin Rafizadeh,Bakhtyar Tartibian,Rasoul Eslami et al.
Nasrin Rafizadeh et al.
G protein-coupled receptors (GPCRs), the largest membrane receptor family, are central to regulating physiological processes such as cellular signaling, metabolism, and immunity. Age-related decline in GPCR function causes the systemic infl...