Stratification of Motor Cortex Excitability to Transcranial Stimulation Uncovers Functional Network Differences in Healthy Older Adults as Revealed by Resting State EEG Functional Coupling in Brain Network [0.03%]
通过静息状态EEG功能连接在脑网络中揭示的健康老年人纹状体兴奋性分层的差异：经颅磁刺激研究
Lorenzo Nucci,Federico Frasca,Chiara Pappalettera et al.
Lorenzo Nucci et al.
Background: Understanding the neural organization underlying motor function is essential for explaining individual differences in motor performance and the impact of aging. ...
GLP-1 at the Metabolic-Cognitive Interface: Reward, Affect, and Memory [0.03%]
GLP-1在代谢-认知界面：奖励、情绪和记忆
Serena X Gao,Léa Décarie-Spain,Cindy Gu et al.
Serena X Gao et al.
Glucagon-like peptide-1 (GLP-1) is a nutrient-responsive hormone classically associated with glucose homeostasis and food intake control, yet its receptor is broadly expressed throughout the central nervous system (CNS) in circuits governin...
PVRI-GoDeep-A Global Meta-Registry at the Crossroads of Heart and Lung [0.03%]
PVRI-GoDeep-全球肺动脉高压注册登记项目：心血管和呼吸系统交叉领域的新视野
Meike T Fuenderich,Athiththan Yogeswaran,Patrick Janetzko et al.
Meike T Fuenderich et al.
Pulmonary hypertension (PH) is a complex disease characterized by increased pressure in the pulmonary arteries. It encompasses a heterogeneous group of entities that increase right heart afterload and often lead to right heart failure and p...
A Single Bout of Aerobic Exercise Increases Neuronal Extracellular Vesicle-Derived Insulin Signaling Biomarkers in Adults With Cardiometabolic Risk [0.03%]
单项有氧运动可增加成人心血管代偿风险患者的神经元细胞外囊泡源性胰岛素信号生物标志物
Steven K Malin,Daniel J Battillo,Michal S Beeri et al.
Steven K Malin et al.
Exercise may lower Alzheimer's Disease and Related Dementia (ADRD) risk. While insulin has been proposed to benefit cognition, the effect of exercise on neuronal insulin signaling in humans is unclear. ...
Randomized Controlled Trial
Comprehensive Physiology. 2026 Apr;16(2):e70131. DOI:10.1002/cph4.70131 2026
The Metabolic Dialogue Between the Gut and Distant Organs: From Microbial Products to Host Responses [0.03%]
肠道与远端器官之间的代谢对话：从微生物产物到宿主反应
Lei Chen,Ming Li,Xin Wang et al.
Lei Chen et al.
The gut microbiota, through its extensive metabolic repertoire, plays a pivotal role in regulating systemic physiological processes and contributing to the pathogenesis of extraintestinal diseases. Key microbial metabolites, including short...
Functional Segregation of Pancreatic Microcirculation Reveals Sex-Dependent Microhemodynamic Signatures [0.03%]
胰腺微循环的功能性分离揭示了性别依赖性的微血流动力学特征
Yuan Li,Yingyu Wang,Bing Wang et al.
Yuan Li et al.
The microcirculation is a determinant of organ function, translating systemic signals into local physiological responses. However, whether the regulation of microhemodynamics is sexually dimorphic within the pancreas has remained unknown. H...
The Exosome-Lactate-Lactylation Axis: A Metabolic-Epigenetic Circuit Driving Tumor Immune Evasion [0.03%]
外泌体-乳酸-乳酸基化轴：调控肿瘤免疫逃逸的代谢表观遗传回路
Yuan Chen,Yuan Yuan,Zhen Zhang et al.
Yuan Chen et al.
Lactylation, as a post-translational modification, plays a role in tumor proliferation, metabolism, and the remodeling of the tumor microenvironment (TME). Emerging studies have revealed that exosomes regulate lactate metabolism by deliveri...
Glucagon-Like Peptide-1 Receptor Agonism and Muscle Health: Vascular and Myocellular Effects on Glucose and Protein Metabolism [0.03%]
胰高血糖素样肽-1受体激动剂与肌肉健康：对葡萄糖和蛋白质代谢的血管和肌细胞效应
Christos S Katsanos,Zhenqi Liu,Philip J Atherton
Christos S Katsanos
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) improve glycaemia and reduce body weight, yet their organ-level actions on skeletal muscle remain incompletely defined. Framing skeletal muscle as an integrated unit of vasculatu...
Correction to "The Impact of High-Intensity Exercise in Normobaric Hypoxia on Right Ventricular Function in Trained and Untrained Men-An Echocardiographic Study" [0.03%]
“ normobaric 富氢氧对训练和未训男性右心室功能影响的高强锻炼的研究——超声心动图研究”的勘误
Published Erratum
Comprehensive Physiology. 2026 Apr;16(2):e70124. DOI:10.1002/cph4.70124 2026
DJ-1 (PARK7) as a Redox-Responsive Integrator of Pancreatic, Hepatic, and Adipose Crosstalk in Glucose Homeostasis [0.03%]
作为血糖稳态中胰腺、肝脏和脂肪信号转导的氧化还原调节整合因子：DJ-1(PARK7)的功能研究
Jayasingha Mudiyanselage Pavithra Sewwandi Jayasingha,Mallika Arachchige Hasantha Madushan,Navodi Sandamini Jayathilaka et al.
Jayasingha Mudiyanselage Pavithra Sewwandi Jayasingha et al.
DJ-1 (PARK7), originally characterized in Parkinson's disease, is increasingly recognized as a redox-sensitive regulator of systemic metabolism. Acting through oxidation-dependent modulation of Cys106, DJ-1 integrates cellular redox cues wi...