Loss of Y Chromosome Associates With Lung and Cardiac Dysfunction in COPD [0.03%]
Y染色体丢失与慢性阻塞性肺疾病患者的肺功能和心功能下降有关
Chanil Valasarajan,Tina Rasper,Jochen Wilhelm et al.
Chanil Valasarajan et al.
This study highlights the previously unknown association of mosaic loss of the Y chromosome to impaired gas exchange and cardiac dysfunction, implicating mosaicism in immune-mediated, multi-organ decline and revealing a mechanistic basis fo...
Navneet Singh,Hilary M DuBrock,Sasha Z Prisco et al.
Navneet Singh et al.
In normal health, the liver and lungs enjoy a close anatomic, physiologic, and functional relationship. In the context of pulmonary vascular disease, however, there is accumulating evidence that the interplay between the gut microbiome, hep...
Duc Huy Hoang Nguyen
Duc Huy Hoang Nguyen
Despite being one of the most densely innervated organs in the thorax, the human heart exhibits a relative insensitivity to chronic visceral pain. Unlike other viscera or enlarging visceral masses of comparable size, progressive mechanical ...
Lactobacillus acidophilus Postbiotics Differentially Modulate Nutrient Sensing, Intestinal Barrier Integrity, and Inflammatory Signaling in Broiler [0.03%]
乳酸菌芽孢杆菌胞外产物通过差异调节营养感应、肠道屏障完整性和炎症信号转导影响 broiler鸡生长性能和免疫功能
Meng Yu,Zhiyun Qin,Atique Ahmed Behan et al.
Meng Yu et al.
The global restriction of antibiotic growth promoters (AGPs) has accelerated the search for sustainable nutritional alternatives that support growth performance and intestinal health of poultry. Postbiotics and their bioactive metabolites d...
Kudret Selin Ozkaya,Kirsteen N Browning
Kudret Selin Ozkaya
Parkinson's disease, characterized by the motor deficits that result from the loss of dopaminergic neurons in the Substantia Nigra pars compacta, is the second most common neurodegenerative disorder worldwide. Parkinson's disease is also co...
Microbiome Guided Precision Pharmacology in Pregnancy: Organ Crosstalk, Maternal-Fetal Drug Disposition, and PBPK-Informed Dosing [0.03%]
孕期精准药物学的微生态指导：器官对话、母胎药代动力学以及基于PBPK的给药方案
Nila Ganamurali,Mohanapriya Devarajan,Sarvesh Sabarathinam
Nila Ganamurali
Drug therapy during pregnancy poses unique challenges, requiring a balance between maternal benefit and fetal safety. Profound physiological changes, including altered plasma volume, protein binding, hepatic metabolism, renal clearance, and...
Threshold Effects of Dietary Components on Global NAFLD Burden: Modulating Role of Socioeconomic Development [0.03%]
饮食成分对全球非酒精性脂肪肝负担的阈值效应：社会经济发展水平的调节作用
Yanqi Kou,Junyi Yang,Guojia Yuan et al.
Yanqi Kou et al.
Non-alcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population worldwide. This study quantifies the global NAFLD burden attributable to 10 dietary components across diverse populations. ...
Oxysterols as Regulators of Inter-Organ Metabolic Communication: Molecular Mechanisms, Disease Associations, and Vulnerable Populations [0.03%]
氧化固醇作为器官间代谢通讯调节因子：分子机制、疾病关联及易感人群
Nila Ganamurali,Madhupriya Prabhakaran,Sarvesh Sabarathinam
Nila Ganamurali
Oxysterols, oxygenated derivatives of cholesterol, are emerging as pivotal regulators of lipid metabolism, cellular communication, and immune responses. Their increased polarity enables rapid intermembrane transport and dynamic signaling fu...
Systemic Consequences of Chronic Ethanol Intake: From Microbiome Shifts to Metabolic Impairment [0.03%]
慢性乙醇摄入的系统性后果：从菌群移位到代谢障碍
Muni Swamy Ganjayi,Thomas A Krauss,Gage E Demster et al.
Muni Swamy Ganjayi et al.
Chronic ethanol (EtOH) consumption is a major contributor to multi-organ dysfunction, yet its systemic effects remain incompletely understood. To address this, we utilized a physiologically relevant long-term mouse model, administering 20% ...
Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions [0.03%]
肺血管疾病中的 adventitial 生态位、补体和炎症：现状与未来方向
Hui Zhang,Ram Raj Prasad,Sushil Kumar et al.
Hui Zhang et al.
There is strong evidence supporting inflammatory and autoimmune processes in the pathogenesis of pulmonary arterial hypertension (PAH), although the initiating and disease-sustaining mechanisms remain unclear. Studies in arthritis, kidney d...