Oksana P Kovalenko,Galyna P Volynets,Mariia Yu Rybak et al. Oksana P Kovalenko et al.

Effective treatment of tuberculosis is challenged by the rapid development of Mycobacterium tuberculosis (Mtb) multidrug resistance that presumably could be overcome with novel multi-target drugs. Aminoacyl-tRNA synthetases (AARSs) are an e...

Riyad Domingo,Renier van der Westhuyzen,Anton R Hamann et al. Riyad Domingo et al.

The biosynthesis of the essential metabolic cofactor coenzyme A (CoA) has been receiving increasing attention as a new target that shows potential to counter the rising resistance to established antimicrobials. In particular, phosphopantoth...

Margherita Mastromarino,Liliya N Kirpotina,Igor A Schepetkin et al. Margherita Mastromarino et al.

Formyl peptide receptor 1 (FPR1) is expressed on a variety of immune system cells and is a key regulator of the inflammatory environment. Therefore, the development of FPR1 antagonists may represent a novel approach for modulating innate im...

Laura Blaikie,Graeme Kay,Paul Kong Thoo Lin Laura Blaikie

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. The number of people suffering from this debilitating disorder is rising at an unprecedented rate, with a subsequent surge in he...

Weicong Liu,Ying Pan,Weiwei Xiao et al. Weicong Liu et al.

The high storage capacities and excellent biocompatibilities of zinc(ii) metal-organic frameworks (Zn-MOFs) have made them outstanding candidates as drug delivery carriers. Recent studies on the pH-responsive processes based on carrier-drug...

Herman O Sintim,Clinton G Mikek,Modi Wang et al. Herman O Sintim et al.

The cyclic dinucleotide-cGAS-STING axis plays important roles in host immunity. Activation of this signaling pathway, via cytosolic sensing of bacterial-derived c-di-GMP/c-di-AMP or host-derived cGAMP, leads to the production of inflammator...

Martina Kulén,Carlos Núñez-Otero,Andrew G Cairns et al. Martina Kulén et al.

Chlamydia trachomatis infections are a global health problem and new approaches to treat C. trachomatis with drugs of high specificity would be valuable. A library of substituted ring fused 2-pyridones has been synthesized and evaluated for...

Rajib Dey,Kathakali De,Riya Mukherjee et al. Rajib Dey et al.

The rapid growth of antibiotic resistance in Staphylococcus aureus coupled with their biofilm forming ability has made the infections difficult to treat with conventional antibiotics. This has created a massive threat towards public health ...

A M Omar,T David,P P Pagare et al. A M Omar et al.

The intracellular polymerization and the concomitant sickling processes, central to the pathology of sickle cell disease, can be mitigated by increasing the oxygen affinity of sickle hemoglobin (HbS). Attempts to develop azolylacryloyl deri...

Pasquale Linciano,Barbara De Filippis,Alessandra Ammazzalorso et al. Pasquale Linciano et al.

PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties and capability to cross the BBB. In th...