Behavioral decline in Shank3Δex4-22 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes [0.03%]
Shank3Δex4-22小鼠在成年早期的行为下降与皮层小清蛋白阳性颗粒细胞谷氨酸能突触变化平行发生
Rajaram Kshetri,James O Beavers,Romana Hyde et al.
Rajaram Kshetri et al.
Background: SHANK3, a gene encoding a synaptic scaffolding protein, is implicated in autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS). Despite evidence of regression or worsening of ASD-li...
Harmonizing two measures of adaptive functioning using computational approaches: prediction of vineland adaptive behavior scales II (VABS-II) from the adaptive behavior assessment system II (ABAS-II) scores [0.03%]
采用计算方法协调两种适应行为测量：从适应行为评估系统Ⅱ（ABAS-Ⅱ）预测威尼兰德适应行为量表Ⅱ（VABS-Ⅱ）的分数
Corinna Smith,Alexandra Lautarescu,Tony Charman et al.
Corinna Smith et al.
Background: Very large sample sizes are often needed to capture heterogeneity in autism, necessitating data sharing across multiple studies with diverse assessment instruments. In these cases, data harmonization can be a ...
Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits [0.03%]
Tph2缺陷大鼠幼崽的社会情感交流：尽管共同筑巢可以改善母体依恋的缺陷，但会加剧生长迟缓
Tianhua Wang,Judith R Homberg,Laura Boreggio et al.
Tianhua Wang et al.
Background: A lack of serotonin (also known as 5-hydroxytryptamine, 5-HT) in the brain due to deficiency of the rate-limiting enzyme in 5-HT synthesis, tryptophan hydroxylase 2 (TPH2), was recently reported to result in i...
Understanding cognitive flexibility in emotional evaluation in autistic males and females: the social context matters [0.03%]
理解自闭症男性和女性在情绪评价中的认知灵活性：社交情境很重要
Adeline Lacroix,Yoann Bennetot-Deveria,Monica Baciu et al.
Adeline Lacroix et al.
Background: Autistic individuals often have difficulty flexibly adjusting their behavior. However, laboratory experiments have yielded inconsistent results, potentially due to various influencing factors, which need to be...
Investigating frank autism: clinician initial impressions and autism characteristics [0.03%]
坦诚自闭症的调查：临床医生的第一印象和自闭症特征
Rebecca R Canale,Caroline Larson,Rebecca P Thomas et al.
Rebecca R Canale et al.
Background: "Frank autism," recognizable through the first minutes of an interaction, describes a behavioral presentation of a subset of autistic individuals that is closely tied to social communication challenges, and ma...
Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome [0.03%]
脆性X综合征中N1听觉事件相关电位幅度可预测BPN14770的血药浓度
Jordan E Norris,Elizabeth M Berry-Kravis,Mark D Harnett et al.
Jordan E Norris et al.
Fragile X syndrome (FXS) is a rare neurodevelopmental disorder caused by a CGG repeat expansion ≥ 200 repeats in 5' untranslated region of the FMR1 gene, leading to intellectual disability and cognitive difficulties, including in the domai...
Developmental trajectories in infants and pre-school children with Neurofibromatosis 1 [0.03%]
神经纤维瘤病1型婴幼儿和学龄前儿童的发展轨迹
Hannah Slevin,Fiona Kehinde,Jannath Begum-Ali et al.
Hannah Slevin et al.
Background: Children with Neurofibromatosis 1 (NF1) show cognitive, behavioural and social differences compared to their peers. However, the age and sequence at which these differences begin to emerge is not fully underst...
Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis [0.03%]
多层生物分析自闭症谱系障碍的特异性遗传途径特征
Lukas S Schaffer,Sophie Breunig,Jeremy M Lawrence et al.
Lukas S Schaffer et al.
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical patterns of social functioning and repetitive/restricted behaviors. ASD commonly co-occurs with ADHD and, despite thei...
Superior temporal sulcus folding, functional network connectivity, and autistic-like traits in a non-clinical population [0.03%]
非临床人群中颞上沟折叠、功能网络连接和自闭症样特征的关系研究
Igor Nenadić,Yvonne Schröder,Jonas Hoffmann et al.
Igor Nenadić et al.
Background: Autistic-like traits (ALT) are prevalent across the general population and might be linked to some facets of a broader autism spectrum disorder (ASD) phenotype. Recent studies suggest an association of these t...
Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder [0.03%]
结构功能耦合揭示自闭症患者的低连通性现象
Peng Qing,Xiaodong Zhang,Qi Liu et al.
Peng Qing et al.
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with alterations in structural and functional coupling in gray matter. However, despite the detectability and modulation of brain sign...