From cognitive abstraction to adaptive behavior: neural bases of concept learning in autistic adolescents [0.03%]
从认知抽象到适应性行为：自闭症青少年概念学习的神经基础
Yijun Chen,Brylee Hawkins,Hannah Puckett et al.
Yijun Chen et al.
Background: Learned knowledge does not consistently generalize to new contexts in autistic individuals, limiting potential for adapting to real-world demands. This challenge is hypothesized to stem from difficulties with ...
JUND-driven stress-responsive astrocytes promote neuronal apoptosis via enhanced gap junction signaling in autism spectrum disorder [0.03%]
自闭症谱系障碍中JUND驱动的应激反应性星形胶质细胞通过增强缝隙连接信号促进神经元凋亡
Qi Wang,Huamin Yin,Qi Jiang et al.
Qi Wang et al.
Background: Dysregulated stress responses are increasingly implicated in the pathophysiology of autism spectrum disorder (ASD). Astrocytes, which are highly vulnerable to stress, critically support neuronal survival; howe...
Subclinical neuropsychiatric trait variation in parents of children with autism spectrum disorder: a cohort study [0.03%]
儿童自闭症谱系障碍患者父母的亚临床神经精神特征变异：队列研究
Lindsay J Mullin,Kai Xia,Jeffrey Wang et al.
Lindsay J Mullin et al.
Background: Many neuropsychiatric conditions share overlapping features underpinned by shared genetics. In this study, we examined the co-aggregation of sub-threshold variation in neuropsychiatric phenotypes in biological...
Bat-Sheva Hadad,Inbar Leon,Marissa Hartston et al.
Bat-Sheva Hadad et al.
Background: Sensory perception in autism is strikingly heterogeneous, with individuals showing both hypo- and hypersensitivity across different sensory domains. While sensory differences are widely recognized as a core fe...
Advantages of combining multiple eye-tracking paradigms for distinguishing young autistic from non-autistic children [0.03%]
结合多种眼动范式区分自闭症儿童和非自闭症儿童的优势
Dan Xu,Lan Zhang,Xiangqin Wang et al.
Dan Xu et al.
Background: Single-paradigm, single-measure eye-tracking protocols have demonstrated utility in distinguishing between autistic and non-autistic children although effect sizes and reproducibility vary. There is a need for...
Nitric oxide inhibition ameliorates cortical proteomic changes in the Cntnap2-/- and Shank3Δ4-22 mouse models of autism spectrum disorder [0.03%]
一氧化氮抑制可缓解Cntnap2-/-shank3Δ4-22自闭症谱系障碍小鼠模型皮层蛋白组学改变
Wisam Bazbaz,Maryam Kartawy,Igor Khaliulin et al.
Wisam Bazbaz et al.
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic component, and over a thousand associated genes have been identified, including CNTNAP2 and SHANK3. Our previous work using...
The Signposting Questionnaire for Autism-2 (SQ-A-2): using input from autistic adults to inform questionnaire development [0.03%]
自闭症标志问卷第二版（SQ-A-2）：利用来自成年人的输入来指导问卷开发
Lucy A Livingston,Susan R Leekam,Gareth Davies et al.
Lucy A Livingston et al.
A novel context-discrepancy assessment of impression management facets in autistic and non-autistic adults: an initial validation [0.03%]
自闭症和非自闭症成人印象管理维度的新型情境差异评估：初步验证
Wei Ai,Jennifer Xiaofan Yu,Benjamin Koshy Jacob et al.
Wei Ai et al.
Background: Some autistic people “camouflage” by modifying autistic characteristics in social situations. Operationalizations of camouflaging remain limited and inconsistent. Quantitative studies primarily use retrospec...
ADNP missense variant p.C687R disrupts chromatin regulation and GABAergic differentiation in Helsmoortel-Van der Aa syndrome [0.03%]
ADNP错义突变p.cys687arg通过干扰染色质调节和Helsmoortel-Van der Aa综合征中的GABA能分化导致疾病发生发展
Qi Chen,Xixi Liu,Mengnan Wu et al.
Qi Chen et al.
Background: Activity-dependent neuroprotective protein (ADNP) is a critical regulator of neurodevelopment, and most pathogenic variants reported in Helsmoortel–Van der Aa syndrome (HVDAS) are truncating variants. In cont...
Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles [0.03%]
草原田鼠在负面情绪的社会传递过程中侧缰核c-Fos表达增加
Daniella Gamboa Pabón,Jolee Hatfield-King,Shivangi Patel et al.
Daniella Gamboa Pabón et al.
Background: Social learning is the process of acquiring social skills, new information, or associating negative or positive valence to a context through the observation of others and through direct social interaction with...