Maternal rheumatoid arthritis and the risk of offspring autism spectrum disorder: two national birth cohorts and a meta-analysis [0.03%]
母亲类风湿性关节炎与子代自闭症谱系障碍风险的关系：两项全国出生队列研究和荟萃分析
Evora Hailin Zhu,Benjamin Hk Yip,Caroline Fyfe et al.
Evora Hailin Zhu et al.
Background: Prenatal maternal rheumatoid arthritis (RA) is postulated to increase the risk of offspring with Autism Spectrum Disorder (ASD), yet findings of the association are inconsistent, potentially owing to small sam...
UBE3A stabilization of β-catenin preserves synaptic proteins essential for motor and cognitive functions in Angelman Syndrome [0.03%]
UBE3A稳定β-catenin保全天使人综合症运动和认知功能必需的突触蛋白
Xin Yang,Yuwen-Alvin Huang,John Marshall
Xin Yang
Background: Ubiquitin protein ligase E3A (UBE3A) regulates signaling pathways associated with autism spectrum disorders (ASDs). As an E3 ligase, UBE3A ubiquitinates and promotes the degradation of proteins crucial for reg...
The impact of camouflaging autistic traits on psychological and physiological stress: a co-twin control study [0.03%]
掩饰自闭症特征对心理和生理压力的影响：一项双生子控制研究
Sabela Conde-Pumpido Zubizarreta,Johan Isaksson,Åshild Faresjö et al.
Sabela Conde-Pumpido Zubizarreta et al.
Background: Camouflaging autistic traits is suggested to increase stress and the risk of autistic burnout. However, the relationship with psychological and biological markers of stress and the influence of familial factor...
Self-harm and suicidality experiences of autistic and non-autistic adults in midlife and old age [0.03%]
中年和老年自闭症成人与非自闭症成人的自伤及自杀意念体验
Sophie Roper,Rebecca Charlton,Francesca Happé et al.
Sophie Roper et al.
Background: Suicide has been reported as a leading cause of premature death in autistic populations. Additionally, risk of suicidality is often found to increase with age in the general population. Despite this, suicidali...
Effects of Metformin on children with Fragile X Syndrome: a randomized, double-blind, placebo-controlled trial [0.03%]
二甲双胍治疗脆性X综合征儿童的临床疗效：随机、双盲、安慰剂对照试验
Yiting Zhu,Dongyun Li,Chunchun Hu et al.
Yiting Zhu et al.
Background: Fragile X Syndrome (FXS) is the most prevalent inherited intellectual disability disorder linked to the X chromosome, and currently lacks an approved specific treatment. Preclinical and some clinical studies h...
Randomized Controlled Trial
Molecular autism. 2025 Nov 25;16(1):57. DOI:10.1186/s13229-025-00691-z 2025
Transdiagnostic similarities and distinctions in brain networks associated with autistic social impairments: a prospective cohort study [0.03%]
与自闭症社交障碍相关的脑网络的跨诊断异同：前瞻性队列研究
Jennifer L Bruno,Julia R Plank,Samantha Leder et al.
Jennifer L Bruno et al.
Background: Despite high rates of autism spectrum disorder (ASD), understanding of pathophysiology is limited. The RAS-mitogen-activated protein kinase (RAS-MAPK) pathway plays a crucial role in ASD and is altered in chil...
Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models [0.03%]
易位型脆性X综合征小鼠模型海马伽玛振荡异常：来自体外脑片模型的见解
Evangelia Pollali,Daniel Frías Donaire,Miguel Del Ángel et al.
Evangelia Pollali et al.
Background: Fragile X syndrome (FXS) is the most common inherited intellectual disability, caused by the loss of fragile X mental retardation protein (FMRP), which regulates neuronal signaling and plasticity. FXS patients...
Exome sequencing in severe non-syndromic specific learning and language disorders in a French cohort [0.03%]
法国人群中严重非综合征性特定学习和语言障碍的外显子组测序研究
Eléonore Viora-Dupont,Julian Delanne,Aurore Garde et al.
Eléonore Viora-Dupont et al.
Background: Specific learning disorders (SLDs) affect approximately 5% of school-age children. In France, genetic investigations of complex non-syndromic SLD cases include chromosomal microarray analysis and fragile X syn...
Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder [0.03%]
自闭症谱系障碍中年龄相关的轴突修剪和髓鞘形成差异可能会改变神经信号转导
Kari L Hanson,Thomas Avino,Sandra L Taylor et al.
Kari L Hanson et al.
Background: Neuronal connectivity is refined throughout development by the proliferation and pruning of axons in cerebral white matter, and progressive axon myelination that enables rapid communication across brain region...
The Developmental Assessment of Social Communication Ability (DASCA): initial creation and psychometric description [0.03%]
儿童社会沟通能力发展评定量表（DASCA）的编制及检验系数描述研究
Aaron J Kaat,Audrey Thurm,Cristan Farmer et al.
Aaron J Kaat et al.
Objective: The dearth of tools to quantify and track growth in social communication ability has been a barrier to understanding and monitoring treatment outcomes for neurodevelopmental disorders. We undertook a multi-stag...
Multicenter Study
Molecular autism. 2025 Oct 16;16(1):52. DOI:10.1186/s13229-025-00683-z 2025