Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism [0.03%]
前额皮质表达生长抑素的中间神经元调节Magel2小鼠自闭症模型中的社交障碍
Xiaona Wang,Mengyuan Chen,Daoqi Mei et al.
Xiaona Wang et al.
Dysfunction in social interactions is a core symptom of autism spectrum disorder (ASD). Nevertheless, the neural mechanisms underlying social deficits in ASD are poorly understood. By integrating electrophysiological, in vivo fiber photomet...
White matter microstructure as a potential contributor to differences in resting state alpha activity between neurotypical and autistic children: a longitudinal multimodal imaging study [0.03%]
白质微结构作为神经典型儿童和自闭症儿童静息状态alpha活动差异的潜在贡献者：一项纵向多模态成像研究
Guannan Shen,Heather L Green,Marybeth McNamee et al.
Guannan Shen et al.
We and others have demonstrated the resting-state (RS) peak alpha frequency (PAF) as a potential clinical marker for young children with autism spectrum disorder (ASD), with previous studies observing a higher PAF in school-age children wit...
Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice [0.03%]
小胶质细胞中Fmr1的产后下调可促进小胶质细胞的反应并导致雌性小鼠的行为改变
Mehdi Hooshmandi,David Ho-Tieng,Kevin C Lister et al.
Mehdi Hooshmandi et al.
Background: Fragile X syndrome is caused by the loss of the Fmr1 gene expression. Deletion of Fmr1 in various neuronal and non-neuronal subpopulations in the brain of mice leads to cell-type-specific effects. Microglia, i...
Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years [0.03%]
30-73岁自闭症成人胼胝体白质和皮层灰质的变化
Young Seon Shin,Danielle Christensen,Jingying Wang et al.
Young Seon Shin et al.
Background: Autism spectrum disorder (ASD) is a lifelong condition that profoundly impacts health, independence, and quality of life. However, research on brain aging in autistic adults is limited, and microstructural var...
Do autistic individuals show atypical performance in probabilistic learning? A comparison of cue-number, predictive strength, and prediction error [0.03%]
自闭症个体在概率学习中表现出非典型性吗？ Cue-number、predictive strength 和 prediction error 的比较研究
Jia Hoong Ong,Lei Zhang,Fang Liu
Jia Hoong Ong
Background: According to recent models of autism, autistic individuals may find learning probabilistic cue-outcome associations more challenging than deterministic learning, though empirical evidence for this is mixed. He...
Comparative Study
Molecular autism. 2025 Mar 4;16(1):15. DOI:10.1186/s13229-025-00651-7 2025
Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice [0.03%]
PDZD8基因双等位基因突变会导致人类和小鼠出现自闭行为
Andreea D Pantiru,Stijn Van de Sompele,Clemence Ligneul et al.
Andreea D Pantiru et al.
Background: Intellectual developmental disorder with autism and dysmorphic facies (IDDADF) is a rare syndromic intellectual disability (ID) caused by homozygous disruption of PDZD8 (PDZ domain-containing protein 8), an in...
Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study [0.03%]
自闭症个体在面对面交流中注视行为的交互动态变化：一项双目跟踪研究
Daniel Tönsing,Bastian Schiller,Antonia Vehlen et al.
Daniel Tönsing et al.
Background: Previous eye-tracking research on autistic individuals has mostly examined the gaze behavior of one individual in response to social stimuli presented on a computer screen, suggesting that there is atypical ga...
Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness [0.03%]
自闭症患者在触摸观察过程中的动态功能适应：连接强度与对社会接触的态度及社交反应能力相关
Haemy Lee Masson
Haemy Lee Masson
Background: Autistic adults experience differences in social interactions involving physical contact. Brain imaging studies suggest that these differences may be related to atypical brain responses to social-affective cue...
Deciphering the genetic basis of developmental language disorder in children without intellectual disability, autism or apraxia of speech [0.03%]
破译非智障、自闭或构音障碍儿童语言发育障碍的遗传基础
Clothilde Ormieres,Marion Lesieur-Sebellin,Karine Siquier-Pernet et al.
Clothilde Ormieres et al.
Background: Developmental language disorder (DLD) refers to children who present with language difficulties that are not due to a known biomedical condition or associated with autism spectrum disorder (ASD) or intellectua...
Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume [0.03%]
自闭症抑郁的理解：主观感知和前扣带回体积的作用
Yu Hao,Sarah Banker,Jadyn Trayvick et al.
Yu Hao et al.
Background: The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet the reasons for this disparity remain unclear. While social deficits central ...