Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms [0.03%]
两类孤独症谱系障碍核心症状的胚胎起源：脑皮层类器官越大，社会交往功能越差
Eric Courchesne,Vani Taluja,Sanaz Nazari et al.
Eric Courchesne et al.
Background: Social affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display improving abilities across early ages and d...
Prospective association of the infant gut microbiome with social behaviors in the ECHO consortium [0.03%]
ECHO联盟中婴儿肠道微生物与社会行为的前瞻性关联研究
Hannah E Laue,Kevin S Bonham,Modupe O Coker et al.
Hannah E Laue et al.
Background: Identifying modifiable risk factors of autism spectrum disorders (ASDs) may inform interventions to reduce financial burden. The infant/toddler gut microbiome is one such feature that has been associated with ...
Moral foundations in autistic people and people with systemizing minds [0.03%]
自闭症人群和偏重系统化思维者身上的道德基础研究
Yeshaya David M Greenberg,Rosemary Holt,Carrie Allison et al.
Yeshaya David M Greenberg et al.
Background: Do autistic people share the same moral foundations as typical people? Here we built on two prominent theories in psychology, moral foundations theory and the empathizing-systemizing (E-S) theory, to observe t...
The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives [0.03%]
自闭症谱系障碍儿童及其一级亲属的语言技能与gamma频段神经振荡的关系研究
Vardan Arutiunian,Megha Santhosh,Emily Neuhaus et al.
Vardan Arutiunian et al.
Background: Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairments and some of these autism-specific language difficulties are also present in their non-autistic first-degree relatives. O...
Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth [0.03%]
自闭症和普通青少年轻度抑郁的病程研究
Blythe A Corbett,Rachael A Muscatello,Trey McGonigle et al.
Blythe A Corbett et al.
Background: Adolescence coincides with a dramatic rise in the onset of psychiatric conditions including depression. Depression symptoms may be particularly prevalent and impairing for youth with autism spectrum disorder (...
Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study [0.03%]
出生窒息与发热性惊厥对自闭症谱系障碍的加性交互作用：基于人口的队列研究
Yi Mao,Xindi Lin,Yuhan Wu et al.
Yi Mao et al.
Background: Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder that can significantly impact an individual's ability to socially integrate and adapt. It's crucial to identify key factors associated ...
Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder [0.03%]
系统综述和荟萃分析：自闭症谱系障碍的功能和解剖神经元变化
Zixuan Guo,Xinyue Tang,Shu Xiao et al.
Zixuan Guo et al.
Background: This meta-analysis aimed to explore the most robust findings across numerous existing resting-state functional imaging and voxel-based morphometry (VBM) studies on the functional and structural brain alteratio...
Meta-Analysis
Molecular autism. 2024 Apr 4;15(1):16. DOI:10.1186/s13229-024-00593-6 2024
Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons [0.03%]
SHANK3缺乏通过激活下丘脑AgRP神经元的p38α激酶诱导自闭症样行为
Shanshan Wu,Jing Wang,Zicheng Zhang et al.
Shanshan Wu et al.
Background: SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) monogenic mutations or deficiency leads to excessive stereotypic behavior and impaired sociability, which frequently occur in autism cases. To date, t...
Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice [0.03%]
神经粘附分子 neuroligin-2 影响小鼠慢波睡眠中单个慢波以及抵抗睡眠剥夺的能力
Tanya Leduc,Hiba El Alami,Khadija Bougadir et al.
Tanya Leduc et al.
Background: Sleep disturbances are a common comorbidity to most neurodevelopmental disorders and tend to worsen disease symptomatology. It is thus crucial to understand mechanisms underlying sleep disturbances to improve ...
Clinical correlates of diagnostic certainty in children and youths with Autistic Disorder [0.03%]
儿童及青少年孤独症诊断确定性的临床相关因素研究
Eya-Mist Rødgaard,Borja Rodríguez-Herreros,Abderrahim Zeribi et al.
Eya-Mist Rødgaard et al.
Background: Clinicians diagnosing autism rely on diagnostic criteria and instruments in combination with an implicit knowledge based on clinical expertise of the specific signs and presentations associated with the condit...