Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue [0.03%]
评估新型磷酰胺前药ProTides的高效抗Varicella-Zoster病毒 bicyclic核苷类似物的2'-氟衍生物的效果
Marco Derudas,Maurizio Quintiliani,Andrea Brancale et al.
Marco Derudas et al.
Background: Recently, the synthesis and antiviral activity of a series of 2'-fluoro derivatives of the most potent anti-varicella zoster virus (VZV) agent reported to date, the bicyclic nucleoside analogue Cf1743, have be...
Nano-NRTIs: efficient inhibitors of HIV type-1 in macrophages with a reduced mitochondrial toxicity [0.03%]
高效的HIV-1宏噬细胞抑制剂nano-nrtis及其降低的线粒体毒性
Serguei V Vinogradov,Larisa Y Poluektova,Edward Makarov et al.
Serguei V Vinogradov et al.
Background: Macrophages serve as a depot for HIV type-1 (HIV-1) in the central nervous system. To efficiently target macrophages, we developed nanocarriers for potential brain delivery of activated nucleoside reverse tran...
Synthesis and biological evaluation of heat-shock protein 90 inhibitors: geldanamycin derivatives with broad antiviral activities [0.03%]
热休克蛋白90抑制剂的合成及生物学评价：一类具有广谱抗病毒活性的格尔德安霉衍生物
Yan-Ping Li,Guang-Zhi Shan,Zong-Gen Peng et al.
Yan-Ping Li et al.
Background: Previous studies have suggested that geldanamycin (GA) inhibits the replication of several viruses in vitro. Here, we aimed to synthesize and evaluate the antiviral activity of 17-amino-17-demethoxygeldanamyci...
Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids [0.03%]
单苯基硼酸作为抗病毒药物的糖结合剂：单苯基硼酸化合物
Paul C Trippier,Christopher McGuigan,Jan Balzarini
Paul C Trippier
Background: The development of carbohydrate-binding agents as novel therapeutics for the inhibition of highly glycosylated enveloped viruses has generated much attention in recent literature. Possessing a potential dual m...
Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication [0.03%]
来源于肉桂的原花青素B1具有抑制丙型肝炎病毒复制的作用
Shenwei Li,Eiichi N Kodama,Yuuki Inoue et al.
Shenwei Li et al.
Background: A combination of pegylated interferon and ribavirin is the current standard therapy for hepatitis C virus (HCV) infection, but this combination provides relatively low efficacy, especially in some patients wit...
Looking for an active conformation of the future HIV type-1 non-nucleoside reverse transcriptase inhibitors [0.03%]
寻找未来HIV-1非核苷类反转录酶抑制剂的活性构象
Giuseppe La Regina,Antonio Coluccia,Romano Silvestri
Giuseppe La Regina
HIV type-1 (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key drugs of highly active antiretroviral therapy (HAART) in the clinical management of AIDS/HIV infection. NNRTI-based HAART regimes effectively suppress viral...
Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice [0.03%]
aurintricarboxylic acid和ethacrynic acid对小鼠呼吸道痘病毒感染无效
Donald F Smee,Brett L Hurst,Min-Hui Wong
Donald F Smee
Background: Aurintricarboxylic acid (ATA) and ethacrynic acid (ECA) have been reported to exhibit antiviral activity against vaccinia virus infections in cell culture by inhibiting early and late gene transcription, respe...
Anti-bovine viral diarrhoea virus activity of novel diphenylmethane derivatives [0.03%]
新型二苯甲烷衍生物的抗牛病毒性腹泻病毒活性
Mohammed T A Salim,Mika Okamoto,Shinnosuke Hosoda et al.
Mohammed T A Salim et al.
Background: A number of compounds were examined for their inhibitory effects on bovine viral diarrhoea virus (BVDV), a surrogate model of hepatitis C virus, in cell cultures. Among them, some diphenylmethane derivatives w...
CCR5 antagonists: host-targeted antiviral agents for the treatment of HIV infection, 4 years on [0.03%]
CCR5拮抗剂：用于治疗HIV感染的宿主导向型抗病毒药物——四年后展望
Mike Westby,Elna van der Ryst
Mike Westby
The chemokine coreceptor 5 (CCR5) antagonists are antiretroviral agents with an extracellular, host-targeted mechanism of action against HIV. Maraviroc, the first-in-class CCR5 antagonist, received regulatory approval in 2007, becoming the ...
Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice [0.03%]
SARS-CoV感染、干扰素α康普隆1和诱导剂对人支气管上皮Calu-3细胞及BALB/c小鼠IFN-γ诱生蛋白10的诱导作用
Yohichi Kumaki,Craig W Day,Kevin W Bailey et al.
Yohichi Kumaki et al.
Background: The pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) is poorly understood. Several mechanisms involving both direct effects on target cells and indirect effects via the immune system mi...