Letermovir use to treat complex cytomegalovirus reactivations in two heart transplant recipients [0.03%]
利特莫维r用于治疗两名心脏移植受者的复杂巨细胞病毒再激活问题
Aude Boignard,Caroline Augier,Mathilde Kheng et al.
Aude Boignard et al.
Letermovir, an anti-cytomegalovirus (CMV) drug, is recommended as a prophylactic agent in patients at risk of CMV infection/reactivation after allogeneic hematopoietic stem cell transplant. We report the curative and pre-emptive use of lete...
EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis B [0.03%]
EDP-514在健康受试者和核苷（t）酸逆转录酶抑制剂抑制的慢性乙型肝炎患者中的应用
Jordan J Feld,Eric Lawitz,Tuan Nguyen et al.
Jordan J Feld et al.
Background: Chronic hepatitis B (CHB) remains a major cause of morbidity and mortality. EDP-514 is a potent core inhibitor of hepatitis B virus (HBV) that reduces viral load reduction in HBV-infected chimeric mice. This f...
Stephen Locarnini,Douglas Richman,Richard Whitley
Stephen Locarnini
Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case-control study from Uganda and South Africa [0.03%]
抗逆转录病毒治疗依从性模式、病毒抑制和药物耐药性的产生：来自乌干达和南非的嵌套病例对照研究
Anisha Tyagi,Yao Tong,Dustin J Rabideau et al.
Anisha Tyagi et al.
Background: Relationships between distinct antiretroviral therapy (ART) adherence patterns and risk of drug resistance are not well understood. Methods: ...
A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection [0.03%]
GSK3732394治疗HIV-1感染的I期随机对照试验：一种研究性长效生物制剂疗法
Mark Krystal,Shiven Chabria,Daren Austin et al.
Mark Krystal et al.
Background: The GSK3732394 multivalent protein was developed as a novel, long-acting, antiretroviral biologic treatment regimen with three independent, non-cross-resistant mechanisms for inhibiting HIV-1 entry. ...
Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor [0.03%]
抗逆转录病毒治疗使与AIDS相关的肝脏Epstein-Barr病毒感染平滑肌瘤代谢完全缓解
Takahide Ara,Tomoyuki Endo,Hideki Goto et al.
Takahide Ara et al.
Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor which occurs in immunocompromised patients. The immune status is an important factor in the treatment of EBV-SMTs, but the efficacy of antiretroviral th...
Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report [0.03%]
拉米夫定与利福平在暴露于结核病的婴儿体内的药代动力学相互作用：案例报告
Marlotte Aa van der Veer,Tom G Jacobs,Laura H Bukkems et al.
Marlotte Aa van der Veer et al.
We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy d...
Outcomes of etravirine-based antiretroviral treatment in treatment-experienced children and adolescents living with HIV in Europe and Thailand [0.03%]
欧洲和泰国既往接受过治疗的HIV感染儿童和青少年使用埃替拉韦为基础抗逆转录病毒治疗结局的研究
European Pregnancy And Paediatric Infections Cohort Collaboration Eppicc,Alex Lyons,Lindsay Thompson et al.
European Pregnancy And Paediatric Infections Cohort Collaboration Eppicc et al.
Background: Etravirine (ETR) is approved as a component of second or third-line antiretroviral treatment (ART) for children living with HIV. We assessed the outcomes of ETR-based ART in children in routine care in Europe ...
The renal-bone axis in older people living with HIV on stable antiretroviral therapy: A sub-analysis of the GS-US-104-0423 study [0.03%]
稳定接受抗逆转录病毒治疗的人类免疫缺陷病毒感染者肾骨轴的亚组分析：GS-US-104-0423研究的结果
Elena Alvarez,Lucy Campbell,Willard Tinago et al.
Elena Alvarez et al.
Background: Data on low bone mineral density (BMD) in people living with HIV (PLWH) are mainly derived from younger adults; little is known about how antiretroviral therapy (ART) and alterations in the renal-bone axis rel...
Resistance levels to non-nucleoside reverse transcriptase inhibitors among pregnant women with recent HIV infection in Malawi [0.03%]
马拉维近期感染HIV的孕妇中非核苷类逆转录酶抑制剂耐药水平
George Bello,Matthew Kagoli,Sikhona Chipeta et al.
George Bello et al.
Background: Information on HIV drug resistance (HIVDR) prevalence in people newly diagnosed with HIV is limited. We implemented a cross-sectional study to estimate HIVDR prevalence among pregnant women recently infected w...