Safety and efficacy of deltoid intramuscular long-acting cabotegravir and rilpivirine, a case series [0.03%]
关于卡博特格拉韦联合利匹韦林肌内注射的疗效和安全性：一系列病例研究
Chloé Pannecoucke,Nadia Valin,Gilles Peytavin et al.
Chloé Pannecoucke et al.
ObjectiveThe objective was to evaluate the safety, pharmacokinetics and efficacy of an alternative deltoid site for CAR-LA.DesignThis is a prospective cohort of people living with HIV (PLWHIV) switching for intramuscular long acting caboteg...
Factors associated with immunological non-response in HIV patients receiving antiretroviral therapy in Southeast Asia: A systematic review [0.03%]
接受抗逆转录病毒治疗的人群中人类免疫缺陷病毒感染者免疫无应答的相关因素：一项系统评价研究
Efrida,Aziizah Yuza
Efrida
ObjectiveThis systematic review summarizes factors associated with immunological non-response (INR) among people with HIV on antiretroviral therapy (ART) in Southeast Asia.MethodsWe conducted a systematic search of PubMed, ScienceDirect, DO...
Epidemiology and clinical management of cytomegalovirus infection in transplant recipients in Central and Eastern Europe - a physician survey [0.03%]
中欧和东欧移植受者巨细胞病毒感染的流行病学及临床管理-医生问卷调查结果
Alicja Dębska-Ślizień,Milena Todorović Balint,Radovan Vrhovac et al.
Alicja Dębska-Ślizień et al.
BackgroundPosttransplant cytomegalovirus (PT-CMV) infection remains a challenging complication and a major cause of morbidity and mortality in transplant recipients.MethodsThis cross-sectional study surveyed physicians treating solid organ ...
It's about time: The association between abacavir and cardiovascular disease [0.03%]
关于时间问题——阿巴卡韦与心血管疾病的关系分析
Jim Young,Patrick R Lawler,Erica E M Moodie et al.
Jim Young et al.
Data from the REPRIEVE trial have been used to study the association between treatment with abacavir and cardiovascular disease in people with HIV. Past exposure to abacavir before the trial was found to be just as risky as exposure during ...
Combination antiviral and anti-CMV immunoglobulin therapy for CMV infection: A case-control study [0.03%]
抗CMV免疫球蛋白联合抗病毒治疗预防CMV感染的疗效分析：病例对照研究
Biagio Pinchera,Ludovica Fusco,Vincenzo Fotticchia et al.
Biagio Pinchera et al.
BackgroundIntravenous hyper-immune anti-cytomegalovirus immunoglobulins (CMV-IG) therapy are licensed for prophylaxis, yet their therapeutic value in established CMV disease remains poorly defined. We aimed to evaluate the clinical and viro...
Harnessing SuperNatural database to identify VP35 inhibitors as anti-Ebola drug candidates: A multistage In silico study [0.03%]
利用SuperNatural数据库寻找VP35抑制剂作为抗埃博拉药物候选物的多阶段虚拟筛选研究
Abeer A M Hasb,Gamal A H Mekhemer,Peter A Sidhom et al.
Abeer A M Hasb et al.
Ebola virus is a member of the Filoviridae family, which causes hemorrhagic fever in primates, exhibiting a mortality rate that can reach up to 90%. The VP35 suppresses the host IFN-β/α production by disrupting the immune responses of the...
Evaluation of combining the PDX analogue AN-137B with oseltamivir in a mouse model of severe influenza A (H1N1) infection [0.03%]
评估PDX类似物AN-137B与奥司他韦联合用于严重甲型流感（H1N1）感染小鼠模型中的抗病毒效果
Yacine Abed,Chantal Rhéaume,Julie Carbonneau et al.
Yacine Abed et al.
Severe influenza infections involve an exacerbation of the pro-inflammatory response, which is influenced by both viral and host factors. Protectins PD1 and PDX previously demonstrated anti-influenza activity as well as anti-inflammatory pr...
A Phase 1 study of the safety, tolerability, and pharmacokinetics of ALG-000184 (pevifoscorvir sodium), a novel Class E capsid assembly modulator, in healthy participants [0.03%]
ALG-000184（匹非西松钠），一种新型E类衣壳组装调节剂在健康参与者中的I期安全性，耐受性和药代动力学研究
Ed Gane,Christian Schwabe,Min Wu et al.
Ed Gane et al.
BackgroundClass E (empty) capsid assembly modulators (CAM-Es) inhibit HBV capsid assembly, pregenomic RNA encapsidation preventing formation the establishment of covalently closed circular HBV DNA (ccDNA). ALG-000184 (pevifoscorvir sodium),...
Enterovirus-associated deafness and myositis in an immunocompromised patient with in vivo and in vitro efficacy of intravenous immunoglobulins and remdesivir: Case report [0.03%]
免疫抑制患者感染肠道病毒后出现的耳聋和肌炎的病例报告及静脉用丙种球蛋白和瑞德西韦的有效性研究
Emma M de Koff,Harmen van Andel,Hanna K de Jong et al.
Emma M de Koff et al.
Enteroviruses can cause severe, chronic infections in patients with primary and secondary humoral immunodeficiencies. These patients may benefit from anti-enteroviral therapy. Here, we report a patient with mantle cell lymphoma treated with...
Best practices for screening, testing, diagnosing, and treating patients with hepatitis D (delta) virus based on global expert review and recent guidelines [0.03%]
基于全球专家评审和最新指南的丁型肝炎（Delta病毒）筛查、检测、诊断和治疗的最佳实践
Markus Cornberg,Fabien Zoulim,Robert Gish et al.
Markus Cornberg et al.
BackgroundHepatitis D virus (HDV) represents the most severe form of human viral hepatitis, associated with rapid progression to cirrhosis and increased liver-related mortality. Globally, an estimated 9-19 million individuals are anti-HDV p...