Evaluation of combining the PDX analogue AN-137B with oseltamivir in a mouse model of severe influenza A (H1N1) infection [0.03%]
评估PDX类似物AN-137B与奥司他韦联合用于严重甲型流感（H1N1）感染小鼠模型中的抗病毒效果
Yacine Abed,Chantal Rhéaume,Julie Carbonneau et al.
Yacine Abed et al.
Severe influenza infections involve an exacerbation of the pro-inflammatory response, which is influenced by both viral and host factors. Protectins PD1 and PDX previously demonstrated anti-influenza activity as well as anti-inflammatory pr...
A Phase 1 study of the safety, tolerability, and pharmacokinetics of ALG-000184 (pevifoscorvir sodium), a novel Class E capsid assembly modulator, in healthy participants [0.03%]
ALG-000184（匹非西松钠），一种新型E类衣壳组装调节剂在健康参与者中的I期安全性，耐受性和药代动力学研究
Ed Gane,Christian Schwabe,Min Wu et al.
Ed Gane et al.
BackgroundClass E (empty) capsid assembly modulators (CAM-Es) inhibit HBV capsid assembly, pregenomic RNA encapsidation preventing formation the establishment of covalently closed circular HBV DNA (ccDNA). ALG-000184 (pevifoscorvir sodium),...
Enterovirus-associated deafness and myositis in an immunocompromised patient with in vivo and in vitro efficacy of intravenous immunoglobulins and remdesivir: Case report [0.03%]
免疫抑制患者感染肠道病毒后出现的耳聋和肌炎的病例报告及静脉用丙种球蛋白和瑞德西韦的有效性研究
Emma M de Koff,Harmen van Andel,Hanna K de Jong et al.
Emma M de Koff et al.
Enteroviruses can cause severe, chronic infections in patients with primary and secondary humoral immunodeficiencies. These patients may benefit from anti-enteroviral therapy. Here, we report a patient with mantle cell lymphoma treated with...
Best practices for screening, testing, diagnosing, and treating patients with hepatitis D (delta) virus based on global expert review and recent guidelines [0.03%]
基于全球专家评审和最新指南的丁型肝炎（Delta病毒）筛查、检测、诊断和治疗的最佳实践
Markus Cornberg,Fabien Zoulim,Robert Gish et al.
Markus Cornberg et al.
BackgroundHepatitis D virus (HDV) represents the most severe form of human viral hepatitis, associated with rapid progression to cirrhosis and increased liver-related mortality. Globally, an estimated 9-19 million individuals are anti-HDV p...
Pharmacokinetic and mass balance characterization of [14C] RAY1216, a SARS-CoV-2 Mpro inhibitor, in healthy Chinese male subjects [0.03%]
[14C]雷西法韦在健康中国男性受试者中的药代动力学和物质平衡研究
Wang Hu,Jiaxiang Ding,Yunqiu Xie et al.
Wang Hu et al.
BackgroundRAY1216 is an alpha-ketoamide-based peptide inhibitor of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) major protease (Mpro). This study evaluated the absorption, distribution, metabolism and excretion of [14C]...
Pediatric darunavir/cobicistat fixed-dose combination tablet for dispersion: Bioequivalence versus separate agents in healthy participants and acceptability in children living with human immunodeficiency virus-1 [0.03%]
儿科达芦那韦/柯比司提固定剂量复方分散片：与单药在健康参与者中的生物等效性及人免疫缺陷病毒-1感染儿童的可接受性研究
Sandy Van Hemelryck,Erika Van Landuyt,Sofie Deleu et al.
Sandy Van Hemelryck et al.
ObjectiveThe bioequivalence of the simplified protease-inhibitor-based HIV-1 antiretroviral regimen darunavir/cobicistat (DRV/COBI) 600/90-mg fixed-dose combination (FDC) tablet dispersed in water was evaluated in healthy adults and swallow...
Randomized Controlled Trial
Antiviral therapy. 2025 Jun;30(3):13596535251349336. DOI:10.1177/13596535251349336 2025
Cost-effectiveness of tenofovir alafenamide fumarate for treatment of chronic hepatitis B: Evidence from a tertiary hospital in Vietnam [0.03%]
富马酸tenofovir艾拉酚胺治疗慢性乙型肝炎的经济效果：越南三级医院证据
Tran Dieu Thuy,Nguyen Thu Ha,Do Duy Cuong et al.
Tran Dieu Thuy et al.
BackgroundThis study aims to evaluate the cost-effectiveness of tenofovir alafenamide fumarate (TAF) versus tenofovir disoproxil fumarate (TDF) for chronic hepatitis B treatment from a payer's perspective in a limited-income context like Vi...
The diagnostic significance of the C-reactive protein (CRP) in HIV/TB coinfection: A systematic review and meta-analysis [0.03%]
HIV/TB合并感染中C反应蛋白(CRP)的诊断价值：系统综述和meta分析
Ying Gao,Wenjuan Ji,Qiuyan Chen
Ying Gao
BackgroundDrug-resistant Mycobacterium tuberculosis strains have challenged efforts to combat tuberculosis (TB), a major global killer. C-reactive protein (CRP) shows promise as a biomarker for TB screening, particularly in HIV-positive cas...
Magnolol inhibits viral replication and enhances antiviral immune responses against porcine reproductive and respiratory syndrome virus (PRRSV) in Marc-145 cells [0.03%]
Magnolol抑制猪繁殖与呼吸综合征病毒(Marc-145细胞)的复制和抗病毒免疫反应增强作用
Shun Li,Mingzhan Zhu,Jingfei Deng et al.
Shun Li et al.
BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that affects swine and causes substantial economic losses in the global pig industry. Despite the availability of vaccines, it remains crucial to explore in...
A review of photodynamic therapy for the treatment of viral skin diseases [0.03%]
光动力疗法治疗病毒感染性疾病皮肤损害的疗效观察
Joanna Bartosińska,Dorota Kowalczuk,Paulina Szczepanik-Kułak et al.
Joanna Bartosińska et al.
Introduction: Photodynamic therapy (PDT) is a two-stage treatment method making use of light energy and a photosensitizer in the presence of oxygen. PDT has already proved to bring good anti-inflammatory and anti-proliferative effects in th...