HIV drug resistance in the era of contemporary antiretroviral therapy: A clinical perspective [0.03%]
当代抗逆转录病毒疗法时代的 HIV 药物耐药性：临床视角
Andrew Carr,Nicola E Mackie,Roger Paredes et al.
Andrew Carr et al.
Contemporary antiretroviral therapy (ART) regimens have high barriers to the development of drug resistance. However, resistance to earlier antiretrovirals and uncommon cases of resistance to contemporary ART illustrate the continued need f...
Computer-assisted drug discovery of potential natural inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase through a multi-phase in silico approach [0.03%]
基于计算机辅助的抗SARS-CoV-2复制酶活性天然产物抑制剂的虚拟筛选与发现
Eslam B Elkaeed,Bshra A Alsfouk,Tuqa H Ibrahim et al.
Eslam B Elkaeed et al.
Background: The COVID-19 pandemic has led to significant loss of life and economic disruption worldwide. Currently, there are limited effective treatments available for this disease. SARS-CoV-2 RNA-dependent RNA polymeras...
Retrospective chart review of transplant recipients with cytomegalovirus infection who received maribavir in the Phase 3 SOLSTICE trial: Data at 52 weeks post-maribavir treatment initiation [0.03%]
III期SOLSTICE试验中接受马里巴韦治疗的巨细胞病毒感染移植受者患者的回顾性图表审查：为期52周的随访数据.post-马里巴韦治疗启动
Marielle Bassel,Dorothy Romanus,Tien Bo et al.
Marielle Bassel et al.
Background: Cytomegalovirus (CMV) infection is a frequent complication in haematopoietic cell/solid organ transplant (HCT/SOT) recipients. Previous studies report all-cause mortality rates of 31% and 50% in HCT/SOT recipi...
Hepatitis C virus/Hepatitis B virus coinfection: Current prospectives [0.03%]
丙型肝炎病毒/乙型肝炎病毒合并感染：当前展望
Quratulain Maqsood,Aleena Sumrin,Maryam Iqbal et al.
Quratulain Maqsood et al.
In endemic areas, hepatitis C virus (HCV)/hepatitis B virus (HBV) coinfection is common, and patients with coinfection have a higher risk of developing liver disease such as hepatocellular carcinoma, liver fibrosis and cirrhosis. In such ca...
Letter to the editor on use of antibodies from convalescent sera in the treatment of moderate and severe Covid-19 infection [0.03%]
致编辑关于使用康复血清中的抗体治疗中重症新冠肺炎感染的信
Sarah B Nahhal,Bassem Awada,Joe-David Azzo et al.
Sarah B Nahhal et al.
Fanconi syndrome, diabetes insipidus, and acute kidney injury due to tenofovir disoproxil fumarate: A case report [0.03%]
富马酸替诺福韦二吡呋酯导致范可尼综合征、尿崩症和急性肾损伤的病例报告
Nthabiseng Zilwa,Onalethata Mpejane,Golam Mehboob et al.
Nthabiseng Zilwa et al.
Background: Tenofovir disoproxil fumarate is widely used in Botswana as part of the first-line antiretroviral regimen in the 'Treat All' strategy implemented in 2016 by the Ministry of Health. Its use has been associated ...
Feminizing hormone therapy in a Canadian cohort of transgender women with and without HIV [0.03%]
加拿大HIV阳性与阴性男变女跨性别者中的 feminising 激素疗法
Ian Armstrong,Ashley Lacombe-Duncan,Mostafa Shokoohi et al.
Ian Armstrong et al.
Background: Potential bidirectional drug-drug interactions between feminizing hormone therapy (FHT) and antiretroviral therapy (ART) are of concern for trans women with HIV and their healthcare providers. This study aimed...
Comparative Study
Antiviral therapy. 2023 Jun;28(3):13596535231182505. DOI:10.1177/13596535231182505 2023
Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study [0.03%]
托帕兹二期临床研究中匹莫 divir 治疗患者中流感病毒株的表型和基因型特征分析
Johan Vingerhoets,Ilse Van Dromme,Wilbert van Duijnhoven et al.
Johan Vingerhoets et al.
Background: Pimodivir is a first-in-class polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A polymerase complex. The randomized double-blinded placebo-controlled phase 2b TOPAZ study demonstrated antivi...
Randomized Controlled Trial
Antiviral therapy. 2023 Jun;28(3):13596535231174273. DOI:10.1177/13596535231174273 2023
The evolution of clinical study design in heavily treatment-experienced persons with HIV: A critical review [0.03%]
艾滋病高治疗经验丰富患者的临床研究设计的演变：批判性回顾
Judith A Aberg,Anthony Mills,Santiago Moreno et al.
Judith A Aberg et al.
Heavily treatment-experienced (HTE) persons with HIV have limited options for antiretroviral therapy and face many challenges, complicating their disease management. There is an ongoing need for new antiretrovirals and treatment strategies ...
A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults [0.03%]
TLR7激动剂JNJ-64794964单次口服给药可诱导健康成人外周免疫细胞转录组和表型改变
Wim Pierson,Marianne Tuefferd,Florence Herschke et al.
Wim Pierson et al.
Background: Chronic hepatitis B (CHB) is responsible for major disease burden worldwide. However, the number of available therapies is limited; cure remains an elusive goal. JNJ-64794964 (JNJ-4964) is an oral toll-like re...