Feminizing hormone therapy in a Canadian cohort of transgender women with and without HIV [0.03%]
加拿大HIV阳性与阴性男变女跨性别者中的 feminising 激素疗法
Ian Armstrong,Ashley Lacombe-Duncan,Mostafa Shokoohi et al.
Ian Armstrong et al.
Background: Potential bidirectional drug-drug interactions between feminizing hormone therapy (FHT) and antiretroviral therapy (ART) are of concern for trans women with HIV and their healthcare providers. This study aimed...
Comparative Study
Antiviral therapy. 2023 Jun;28(3):13596535231182505. DOI:10.1177/13596535231182505 2023
Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study [0.03%]
托帕兹二期临床研究中匹莫 divir 治疗患者中流感病毒株的表型和基因型特征分析
Johan Vingerhoets,Ilse Van Dromme,Wilbert van Duijnhoven et al.
Johan Vingerhoets et al.
Background: Pimodivir is a first-in-class polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A polymerase complex. The randomized double-blinded placebo-controlled phase 2b TOPAZ study demonstrated antivi...
Randomized Controlled Trial
Antiviral therapy. 2023 Jun;28(3):13596535231174273. DOI:10.1177/13596535231174273 2023
The evolution of clinical study design in heavily treatment-experienced persons with HIV: A critical review [0.03%]
艾滋病高治疗经验丰富患者的临床研究设计的演变：批判性回顾
Judith A Aberg,Anthony Mills,Santiago Moreno et al.
Judith A Aberg et al.
Heavily treatment-experienced (HTE) persons with HIV have limited options for antiretroviral therapy and face many challenges, complicating their disease management. There is an ongoing need for new antiretrovirals and treatment strategies ...
A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults [0.03%]
TLR7激动剂JNJ-64794964单次口服给药可诱导健康成人外周免疫细胞转录组和表型改变
Wim Pierson,Marianne Tuefferd,Florence Herschke et al.
Wim Pierson et al.
Background: Chronic hepatitis B (CHB) is responsible for major disease burden worldwide. However, the number of available therapies is limited; cure remains an elusive goal. JNJ-64794964 (JNJ-4964) is an oral toll-like re...
Lipid and glucose abnormalities and associated factors among children living with HIV in Asia [0.03%]
亚洲HIV感染儿童的血脂和血糖异常及其相关因素分析
Tulathip Suwanlerk,Dhanushi Rupasinghe,Watsamon Jantarabenjakul et al.
Tulathip Suwanlerk et al.
Background: Children living with HIV (CLHIV) on prolonged antiretroviral therapy (ART) are at risk for lipid and glucose abnormalities. Prevalence and associated factors were assessed in a multicentre, Asian longitudinal ...
Abacavir safety and effectiveness in young infants with HIV in South African observational cohorts [0.03%]
南非观察队列中婴儿HIV患者使用阿巴卡韦的安全性及有效性研究
Reneé de Waal,Helena Rabie,Karl-Günter Technau et al.
Reneé de Waal et al.
Background: WHO guidelines recommend abacavir in first-line antiretroviral treatment for children and neonates. However, there is no approved dose
Observational Study
Antiviral therapy. 2023 Feb;28(2):13596535231168480. DOI:10.1177/13596535231168480 2023
Treatment-related early discontinuations and adverse events among newly diagnosed people living with HIV initiating integrase inhibitors in a real-world setting [0.03%]
治疗相关的早期停药和不良事件——在真实世界中启动整合酶抑制剂初治HIV感染者的特征分析
Charlotte-Paige Rolle,Jamie Castano,Vu Nguyen et al.
Charlotte-Paige Rolle et al.
Background: Cohort studies suggest higher discontinuation rates with integrase strand transfer inhibitors (INSTIs) than are seen in clinical trials. We assessed discontinuations and adverse events (AEs) that were consider...
Case report and literature review: A hiccup patient developed encephalitis and duodenal perforation [0.03%]
个例报告及文献复习：一例呃逆合并脑炎和十二指肠穿孔患者
Fanfeng Kong,Xiao Xue Zeng
Fanfeng Kong
Brainstem encephalitis is rare and this study aims to report the clinical course, imaging features, and therapeutic response of hiccup patient with gastric ulcer who developed brainstem encephalitis with Epstein-Barr virus (EBV) detected in...
Efficacy, safety and tolerability of Biktarvy in HIV-1 infection: A scoping review [0.03%]
Biktarvy治疗 HIV-1 感染的疗效、安全性和耐受性：系统评价
Ellen Peters,And Collins Iwuji
Ellen Peters
Background: Biktarvy is approved for use in HIV-1 infection in both treatment-naïve and treatment-experienced individuals, after a series of successful phase III trials. However, studies on real-world evidence on its efficacy, safety and t...
Inhibition of chikungunya virus replication by N-ω-Chloroacetyl-L-Ornithine in C6/36, Vero cells and human fibroblast BJ [0.03%]
N-ω-Chloroacetyl-L-Ornithine抑制登革病毒复制作用及其机制研究
Lucero Rojas-Luna,Araceli Posadas-Modragón,Amanda M Avila-Trejo et al.
Lucero Rojas-Luna et al.
Background: Polyamines are involved in several cellular processes and inhibiting their synthesis affects chikungunya virus (CHIKV) replication and translation, and, therefore, reduces the quantity of infectious viral part...