In-silico approach to characterize the structure and function of a hypothetical protein of Monkeypox virus exploring Chordopox-A20R domain-containing protein activity [0.03%]
基于计算的表征猴痘病毒假想蛋白质结构和功能的方法并探索弦多瘤病毒感染A20R区域含有的蛋白质活性
Md Iqbal Hosen,Md Easin Mia,Md Nur Islam et al.
Md Iqbal Hosen et al.
Background: Monkeypox has emerged as a noteworthy worldwide issue due to its daily escalating case count. This illness presents diverse symptoms, including skin manifestations, which have the potential to spread through contact. The transmi...
Assessment of swallowability and acceptability of scored darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) fixed-dose combination (FDC) tablets in HIV-1-infected children aged ≥6 to <12 years, using matching placebo tablets: A randomized study [0.03%]
评估利匹韦林分散片在HIV-1感染儿童中的吞咽性和可接受性：一项在中国开展的开放标签、多中心研究
Sandy Van Hemelryck,Erika Van Landuyt,Veerle Hufkens et al.
Sandy Van Hemelryck et al.
Background: Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) fixed-dose combination (FDC) was developed as a once-daily, complete antiretroviral (ARV) regimen therapy to address the need for simplified...
Adverse drug reactions attributed to generic substitution of antiretroviral medications among HIV treatment and pre-exposure prophylaxis clients in British Columbia, Canada [0.03%]
加拿大不列颠哥伦比亚省HIV治疗和暴露前预防客户的抗逆转录病毒药物通用替代引起的不良药物反应
Katherine J Lepik,Olivia L Hunt,Nic Bacani et al.
Katherine J Lepik et al.
Background: In British Columbia, antiretrovirals (ARVs) for HIV treatment (HIV-Tx) and pre-exposure prophylaxis (PrEP) are free-of-charge through publicly-funded Drug Treatment Programs (DTPs). When available, less costly...
Failure of bamlanivimab with selection of E484K mutation in an allogeneic stem cell transplant recipient with nosocomial SARS-CoV-2 infection [0.03%]
异体干细胞移植患者中发生对bamlanivimab耐药并筛选出E484K突变的院内SARS-CoV-2感染
Inès Boussen,Maud Salmona,Flore Sicre De Fontbrune et al.
Inès Boussen et al.
We report the case of an allogeneic stem cell transplant recipient with nosocomial acquisition of SARS-CoV-2 infection who received antispike neutralizing monoclonal antibody bamlanivimab 2 days after diagnosis of SARS-CoV-2 infection but p...
Cross-resistance to entry inhibitors and lenacapavir resistance through Week 52 in study CAPELLA [0.03%]
CAPELLA研究中截至第52周进入抑制剂和lenacapavir的交叉耐药性
Nicolas Margot,Nina Pennetzdorfer,Vidula Naik et al.
Nicolas Margot et al.
Background: Lenacapavir (LEN) is a first-in-class inhibitor of human immunodeficiency virus type 1 (HIV-1) capsid function for the treatment of heavily treatment-experienced people with HIV (PWH) harbouring multidrug resi...
Dolutegravir and rilpivirine as successful initial antiretroviral therapy in a treatment-naive patient with HIV-1: A case report [0.03%]
一线使用多替拉韦和利匹韦林治疗HIV-1感染的效果良好：一例报道
S Jawad Zafar,Bruce L Gilliam,Sarah A Schmalzle
S Jawad Zafar
RVX-208, an inducer of Apolipoprotein A-I, inhibits the particle production of hepatitis B virus through activation of cGAS-STING pathway [0.03%]
RVX-208通过激活cGAS-STING途径抑制乙肝病毒颗粒产生
Dan Shu,Lin Cheng,Kefei Yuan et al.
Dan Shu et al.
Background: Previously, we have demonstrated that Apolipoprotein A-I (ApoA-I) could inhibit the secretion of Hepatitis B virus (HBV), suggesting that stimulation of ApoA-I may block particle production. In the present stu...
Waitlist-controlled trial of an online intervention to address mental health among older people living with HIV [0.03%]
一项针对HIV阳性老年人在线干预以解决精神健康问题的等候名单控制试验
Jeff Berko,Peter Mazonson,Duncan Short et al.
Jeff Berko et al.
Background: Older people living with HIV (PLWH) often experience elevated levels of depression, anxiety, and loneliness.Methods: This waitlist-controlled trial examined the effectiveness of online audio mindfulness lessons in impacting thes...
Randomized Controlled Trial
Antiviral therapy. 2023 Dec;28(6):13596535231216311. DOI:10.1177/13596535231216311 2023
Subacute thyroiditis following COVID-19 vaccination: Case presentation [0.03%]
新型冠状病毒疫苗接种后发生的亚急性甲状腺炎：病例报告
Aleksandra Z Tomic,Sonja S Zafirovic,Zoran M Gluvic et al.
Aleksandra Z Tomic et al.
Background: Subacute thyroiditis (SAT) is an organ-specific disease that various drugs, including COVID-19 vaccines, can trigger. COVID-19 infection has been associated with thyroid gland damage and disease SARS-CoV-2 direct action, euthyro...
Andrographolide inhibits infectious bronchitis virus-induced apoptosis, pyroptosis, and inflammation [0.03%]
安卡化合物通过抑制凋亡、焦亡和炎症来对抗禽流感病毒感染呼吸道上皮细胞的作用研究
Jiachen Shen,Qiuchi Xu,Lu Chen et al.
Jiachen Shen et al.
Background: Avian infectious bronchitis virus (IBV), a coronavirus, causes a huge economic loss to the poultry industry. Andrographolide (APL) is a compound with a variety of pharmacological properties, including antivira...