Pharmacokinetic and mass balance characterization of [14C] RAY1216, a SARS-CoV-2 Mpro inhibitor, in healthy Chinese male subjects [0.03%]
[14C]雷西法韦在健康中国男性受试者中的药代动力学和物质平衡研究
Wang Hu,Jiaxiang Ding,Yunqiu Xie et al.
Wang Hu et al.
BackgroundRAY1216 is an alpha-ketoamide-based peptide inhibitor of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) major protease (Mpro). This study evaluated the absorption, distribution, metabolism and excretion of [14C]...
Pediatric darunavir/cobicistat fixed-dose combination tablet for dispersion: Bioequivalence versus separate agents in healthy participants and acceptability in children living with human immunodeficiency virus-1 [0.03%]
儿科达芦那韦/柯比司提固定剂量复方分散片：与单药在健康参与者中的生物等效性及人免疫缺陷病毒-1感染儿童的可接受性研究
Sandy Van Hemelryck,Erika Van Landuyt,Sofie Deleu et al.
Sandy Van Hemelryck et al.
ObjectiveThe bioequivalence of the simplified protease-inhibitor-based HIV-1 antiretroviral regimen darunavir/cobicistat (DRV/COBI) 600/90-mg fixed-dose combination (FDC) tablet dispersed in water was evaluated in healthy adults and swallow...
Randomized Controlled Trial
Antiviral therapy. 2025 Jun;30(3):13596535251349336. DOI:10.1177/13596535251349336 2025
Cost-effectiveness of tenofovir alafenamide fumarate for treatment of chronic hepatitis B: Evidence from a tertiary hospital in Vietnam [0.03%]
富马酸tenofovir艾拉酚胺治疗慢性乙型肝炎的经济效果：越南三级医院证据
Tran Dieu Thuy,Nguyen Thu Ha,Do Duy Cuong et al.
Tran Dieu Thuy et al.
BackgroundThis study aims to evaluate the cost-effectiveness of tenofovir alafenamide fumarate (TAF) versus tenofovir disoproxil fumarate (TDF) for chronic hepatitis B treatment from a payer's perspective in a limited-income context like Vi...
The diagnostic significance of the C-reactive protein (CRP) in HIV/TB coinfection: A systematic review and meta-analysis [0.03%]
HIV/TB合并感染中C反应蛋白(CRP)的诊断价值：系统综述和meta分析
Ying Gao,Wenjuan Ji,Qiuyan Chen
Ying Gao
BackgroundDrug-resistant Mycobacterium tuberculosis strains have challenged efforts to combat tuberculosis (TB), a major global killer. C-reactive protein (CRP) shows promise as a biomarker for TB screening, particularly in HIV-positive cas...
Magnolol inhibits viral replication and enhances antiviral immune responses against porcine reproductive and respiratory syndrome virus (PRRSV) in Marc-145 cells [0.03%]
Magnolol抑制猪繁殖与呼吸综合征病毒(Marc-145细胞)的复制和抗病毒免疫反应增强作用
Shun Li,Mingzhan Zhu,Jingfei Deng et al.
Shun Li et al.
BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that affects swine and causes substantial economic losses in the global pig industry. Despite the availability of vaccines, it remains crucial to explore in...
A review of photodynamic therapy for the treatment of viral skin diseases [0.03%]
光动力疗法治疗病毒感染性疾病皮肤损害的疗效观察
Joanna Bartosińska,Dorota Kowalczuk,Paulina Szczepanik-Kułak et al.
Joanna Bartosińska et al.
Introduction: Photodynamic therapy (PDT) is a two-stage treatment method making use of light energy and a photosensitizer in the presence of oxygen. PDT has already proved to bring good anti-inflammatory and anti-proliferative effects in th...
Seroprevalence, seroconversion, and mother-to-child transmission of dual and triplex infections of HIV, HBV, and HCV among Nigerian obstetric population: A national multicentre prospective cohort study [0.03%]
尼日利亚妇产科人群HIV、HBV和HCV双重和三重感染的血清流行率、血清转化及母婴传播：一项全国多中心前瞻性队列研究
George Uchenna Eleje,Hadiza Abdullahi Usman,Chinyere Ukamaka Onubogu et al.
George Uchenna Eleje et al.
ObjectivesTo determine seroprevalence, seroconversion, and mother-to-child transmission (MTCT) rates for dual and triplex infections of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) among pregnant ...
Multicenter Study
Antiviral therapy. 2025 Apr;30(2):13596535251333259. DOI:10.1177/13596535251333259 2025
Sustained viral suppression with once daily dolutegravir-containing regimen in presence of the strong inducer carbamazepine [0.03%]
卡马西平诱导情况下每日一次含多替拉韦方案能持续抑制病毒拷贝数
Micol Pallanza,Paul Thoueille,Myriam Briki et al.
Micol Pallanza et al.
Dolutegravir 50 mg twice daily (BID) dosing is currently recommended in presence of strong inducers of drug metabolism. However, this dosing has been challenged by studies showing similar rates of viral suppression with dolutegravir once da...
Durability of multi-drug antiretroviral therapy (mega-ART) in treatment-experienced people with HIV in the ARCA database [0.03%]
ARCA数据库中经治HIV感染者的多药抗逆转录病毒疗法（ mega-ART）的持久性
Laura Labate,Barbara Rossetti,Chiara Russo et al.
Laura Labate et al.
ObjectiveTo explore the durability of multi-drug antiretroviral regimens in treatment-experienced PWH.DesignThis retrospective observational study including PWH who started mega-ART regimens between 1 January 2009 and 31 December 2019, sele...
Observational Study
Antiviral therapy. 2025 Apr;30(2):13596535251317054. DOI:10.1177/13596535251317054 2025
Functional foods and immune system: A sustainable inhibitory approach against SARS-COV-2 [0.03%]
功能性食品与免疫系统：对抗SARS-COV-2的可持续抑制方法
Hubza Ruatt Khan,Rabia Sultan,Mehvish Javeed et al.
Hubza Ruatt Khan et al.
Background: COVID-19 has become the center of attention since its outbreak in December 2019. Despite the discovery of its preventive vaccine, role of healthy immune system is undebatable. Functional foods are continuously hunted as a promis...