Kevin Peterson,Sarah Rowland-Jones
Kevin Peterson
Many of the antiretrovirals used against HIV-1 are either ineffective or less effective in HIV-2 infection. There is in vitro evidence of the potency of maraviroc and several investigational agents against HIV-2. We conclude that, whilst sp...
HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes [0.03%]
HIV-1 Tat蛋白可干扰人类SGBS脂肪细胞的脂肪形成并促进促炎症细胞因子的表达和分泌
Julieta Díaz-Delfín,Pere Domingo,Martin Wabitsch et al.
Julieta Díaz-Delfín et al.
Background: HIV-1 Tat protein has been shown to play multiple roles in the pathogenesis of AIDS; however, there is no information currently available on its effects on adipose tissue alterations. We have studied the effec...
Effect of abacavir on acute changes in biomarkers associated with cardiovascular dysfunction [0.03%]
阿巴卡韦对心血管功能生物标志物急性变化的影响
Pragna Patel,Tim Bush,Turner Overton et al.
Pragna Patel et al.
Background: This study examined the effect of abacavir on acute changes in biomarkers associated with cardiovascular dysfunction. Methods: ...
Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy [0.03%]
在早期诊断和抗病毒治疗背景下住院孕妇2009A(H1N1)甲型流感的预后情况分析
José Ramón Paño-Pardo,Jesús Rodríguez-Baño,Nuria Martínez-Sánchez et al.
José Ramón Paño-Pardo et al.
Background: Initial reports suggested that novel A(H1N1) influenza virus (2009 A[H1N1]v) infection was significantly more severe in pregnant than in non-pregnant women. In Spain, antiviral therapy was recommended for preg...
The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients [0.03%]
维生素D受体基因bAt（CCA）单倍型可损害慢性丙型肝炎患者对聚乙二醇干扰素/利巴韦林为基础的治疗的反应
Katharina Baur,Joachim C Mertens,Johannes Schmitt et al.
Katharina Baur et al.
Background: Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of...
Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones [0.03%]
含有依法韦恩兹的HIV方案中，不同核苷类反转 transcriptase抑制剂后坐骨神经脂肪组织代谢改变的证据
Kirsty C McGee,Mohsen Shahmanesh,Meg Boothby et al.
Kirsty C McGee et al.
Background: Antiretroviral (ARV) treatment has been associated with abnormalities in lipid and mitochondrial metabolism. We compared patterns of gene expression in the subcutaneous adipose tissue (SAT) of HIV-positive sub...
Randomized Controlled Trial
Antiviral therapy. 2012;17(3):495-507. DOI:10.3851/IMP2017 2012
Continuous interferon-α2b infusion in combination with ribavirin for chronic hepatitis C in treatment-experienced patients [0.03%]
干扰素-α2b连续输注联合利巴韦林治疗经治慢性丙型肝炎患者
Robert Roomer,Jilling F Bergmann,Andre Boonstra et al.
Robert Roomer et al.
Background: Sustained virological response (SVR) rates in previous non-responders to pegylated interferon (PEG-IFN)-α and ribavirin for chronic HCV remain low (~10%). We hypothesize that continuous subcutaneous delivery ...
Randomized Controlled Trial
Antiviral therapy. 2012;17(3):509-17. DOI:10.3851/IMP2016 2012
The prevalence of darunavir-associated mutations in HIV-1-infected children in the UK [0.03%]
英国HIV-1感染儿童中达芦那韦相关突变的流行率
Katherine L Donegan,A Sarah Walker,David Dunn et al.
Katherine L Donegan et al.
Background: We examined the prevalence of ritonavir-boosted darunavir (DRV) resistance-associated mutations (RAMs) in HIV-infected children in the UK to determine the drug's potential clinical utility as a first-line or s...
Control of HBV replication by antiviral microRNAs transferred by lentiviral vectors for potential cell and gene therapy approaches [0.03%]
利用慢病毒载体转移抗病毒microRNA控制HBV复制的体内研究
Mukesh Kumar,Antonia Follenzi,Scott Garforth et al.
Mukesh Kumar et al.
Background: Because molecular mechanisms regulating host cell and virus interactions are not fully understood, we further defined roles of antiviral microRNAs (miRNAs) in HBV replication. ...
Increased CD34+/KDR+ cells are not associated with carotid artery intima-media thickness progression in chronic HIV-positive subjects [0.03%]
慢性HIV感染者血液循环中CD34+/KDR+细胞增加与颈动脉内膜-中层厚度进展无关
Emmanouil Papasavvas,Priscilla Hsue,Griffin Reynolds et al.
Emmanouil Papasavvas et al.
Background: Endothelial progenitor cells (EPCs) are involved in the endothelium repair. Low circulating EPC levels are predictive of cardiovascular events in HIV-negative subjects. The impact of HIV infection on EPCs, and...