Effects of age, sex, and renal function on bowel movement-improving effects of Bifidobacterium bifidum G9-1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study [0.03%]
年龄、性别和肾功能对Bb-G9-1改善2型糖尿病合并慢性肾脏病患者便秘效果的影响：BIRDIE研究的预设亚组分析
Fuki Ikeda,Junko Sato,Hidenori Yoshii et al.
Fuki Ikeda et al.
Introduction: Type 2 diabetes mellitus and chronic kidney disease are associated with increasing risk of constipation. We previously reported that Bifidobacterium bifidum G9-1 improved stool consistency, bowel movement, a...
Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications [0.03%]
利拉鲁肽和杜拉唐普利对眼部和肾脏并发症发生率或进展影响的比较研究
Aki Katamine,Junko Oya,Yuichiro Kondo et al.
Aki Katamine et al.
Aims: To evaluate and compare the risk of diabetic retinopathy and kidney disease between once-daily liraglutide and once-weekly dulaglutide in Japanese participants with type 2 diabetes (T2D). ...
Heat shock protein 72 attenuates atherosclerosis in apolipoprotein E-deficient mice [0.03%]
热休克蛋白72可减轻载脂蛋白E缺乏型小鼠的动脉粥样硬化病情
Rintaro Yoshizumi,Tatsuya Kondo,Takuro Watanabe et al.
Rintaro Yoshizumi et al.
Background: Heat shock (HS) and mild electrical stimulation (MES) induce the expression of heat shock protein 72 (HSP72), which suppresses endoplasmic reticulum stress, oxidative stress, and c-Jun N-terminal kinase (JNK) ...
The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers [0.03%]
基因介导肠道菌群对2型糖尿病影响的中介作用及诊断标志物筛查
Yu-Yang Chen,Yi-Fan Shi,Xin-Yue Zhang et al.
Yu-Yang Chen et al.
Introduction: The composition of intestinal flora affects the occurrence and development of type 2 diabetes to some extent, with dysregulation of the microbiome being a clinical manifestation of the disease. ...
Targeting the miR-224-5p/PTEN pathway: A previously under-characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy [0.03%]
靶向miR-224-5p/PTEN通路：一种先前未充分研究的策略，可通过减轻糖尿病肾病中系膜细胞损伤来改善预后
Yanxia Gao,Xiaohui Zhang,Peng Lu et al.
Yanxia Gao et al.
Aim: To ascertain the expression status and clinical performance of miR-224-5p in diabetic nephropathy (DN), alongside its molecular mechanism of regulating mesangial cell injury by targeting phosphatase and tensin homolo...
Diagnostic performance of SD-ΔRR during physical stressors for identifying diabetic sensorimotor polyneuropathy [0.03%]
SD-ΔRR在生理应激下诊断糖尿病感觉运动神经病变的性能
Katsuyoshi Katayama,Haruhito A Uchida,Toshihiko Nagao et al.
Katsuyoshi Katayama et al.
Aims: This study aimed to evaluate the clinical efficacy of SD-ΔRR as a novel methodology for short-duration heart rate variability (HRV) assessment for the diagnosis of diabetic sensorimotor polyneuropathy (DSPN) in pat...
Combined sleep behaviors, mediating biomarkers, and incident vascular complications among individuals with type 2 diabetes: A prospective study in UK Biobank [0.03%]
英国生物银行中2型糖尿病患者的综合睡眠行为、介导生物标志物和血管并发症的发病率：一项前瞻性研究
Yanqiu Zou,Xia Jiang,Jinyu Zhou et al.
Yanqiu Zou et al.
Aims: To prospectively examine how combined sleep behaviors affect vascular complications in type 2 diabetes, whether these associations are modified by disease severity, as well as the mediating roles of clinical biomark...
USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6-induced ferroptosis and angiogenesis inhibition [0.03%]
USP30通过促进TRAF6诱导的铁死亡和抑制血管生成来抑制糖尿病足溃疡愈合
Jingjing Yuan,Shuang Sui,Zhenghua Yang et al.
Jingjing Yuan et al.
Background: Diabetic foot ulcers (DFUs) frequently complicate diabetes. Ubiquitin-specific protease 30 (USP30), a key deubiquitinating enzyme, is implicated in diverse diseases. This study explores USP30's effects and mec...
Intensified multifactorial intervention leads to long-term benefit on kidney outcomes in advanced diabetic kidney disease: A 10-year follow-up of the DNETT-Japan trial [0.03%]
强化综合干预可长期改善糖尿病肾病患者的肾脏结局：DNETT-Japan研究的10年随访结果
Kenichi Shikata,Satoshi Miyamoto,Masakazu Haneda et al.
Kenichi Shikata et al.
Introduction: Despite recent therapeutic advances in slowing kidney disease progression, the long-term efficacy of intensive multifactorial treatment in advanced-stage diabetic kidney disease remains unclear. We assessed ...