High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study [0.03%]
WTAP高表达作为结直肠癌预后不良生物标志物的初步研究
Michela Relucenti,Claudia Tito,Paolo Mercantini et al.
Michela Relucenti et al.
Colorectal cancer (CRC) is a major public health concern and identifying prognostic molecular biomarkers can help stratify patients based on risk profiles, thus enabling personalized medicine. Epitranscriptomic modifications play a relevant...
The matrix stiffness is increased in the eutopic endometrium of adenomyosis patients: a study based on atomic force microscopy and histochemistry [0.03%]
子宫腺肌病患者宫腔内膜 stiffness 增加的初步研究：原子力显微镜及组织化学检测结果
Xiaowen Wang,Wenbin Cai,Ting Liang et al.
Xiaowen Wang et al.
Previous ultrasound studies suggest that patients with adenomyosis (AM) exhibit increased uterine cavity stiffness, although direct evidence regarding extracellular matrix (ECM) content and its specific impact on endometrial stiffness remai...
Effect of Danggui Buxue decoction on hypoxia-induced injury of retinal Müller cells in vitro [0.03%]
当归补血汤对缺氧诱导的视网膜Müller细胞损伤的影响
Xilin Ge,Caoxin Huang,Wenting Chen et al.
Xilin Ge et al.
Retinopathy is a common complication of diabetes mellitus and the leading cause of visual impairment. Danggui Buxue decoction (RRP) has been used as a traditional drug for the treatment of diabetic nephropathy for many years. The aim of thi...
Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress [0.03%]
circEEF2/miR-625-5p/TRPM2轴活化通过线粒体应激激活Hedgehog通路促进前列腺癌细胞增殖
ChenHui Zhu,LiJuan Lin,ChangQing Huang et al.
ChenHui Zhu et al.
The purpose of this study was to identify the role played by circEEF2 (has-circ-0048559) in prostate cancer (PCa) development and to determine the potential mechanism involved. circEEF2, miR-625-5p, and the transient receptor potential M2 c...
Wenjing Liu,Yongchun Zhang,Cheng Liang et al.
Wenjing Liu et al.
This study investigated the expression of calretinin (CR) in the mouse cochlea from embryonic day 17 (E17) to adulthood through immunofluorescence. At E17, CR immunoreactivity was only detected in the inner hair cells (IHCs). At E19, the IH...
Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction [0.03%]
ALARLIN通过调节RyR2和SERCA2来改善射血分数保留的心力衰竭的心脏功能
Jinshuang Li,Dawei Xu,Ce Shi et al.
Jinshuang Li et al.
Heart failure with preserved ejection fraction (HFpEF), a complex disease that is increasingly prevalent due to population aging, pose significant challenges in its treatment. The present study utilized the HFpEF rat model and H9C2 cells as...
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment [0.03%]
绞股蓝苷IV通过重塑肿瘤微环境增强抗PD-1治疗以抑制肺癌生长
Tao Wu,Shikui Wu,Hui Gao et al.
Tao Wu et al.
Programmed cell death protein-1 (PD-1) inhibitors are increasingly utilized in the treatment of lung cancer (LC). Combination therapy has recently gained popularity in treating LC. This study aimed to assess the efficacy of combining Astrag...
Developmental characteristics of cutaneous telocytes in late embryos of the silky fowl [0.03%]
丝光鸡胚胎晚期皮肤.tel细胞的发育特征
Hao Li,Junliang Chen,Wenjun You et al.
Hao Li et al.
Telocytes (TCs) have been identified in various animals. However, information on TCs in the embryos is still very limited. In this work, the developing skin of the silky fowl was sampled for TCs identification by histology, immunohistochemi...
Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy [0.03%]
irisin通过激活AMPK/mTOR介导的自噬抑制PDGF-BB诱导的血管平滑肌细胞增殖
Fenqiang Qi,Yuxin Deng,Wei Huang et al.
Fenqiang Qi et al.
Restenosis is a pivotal factor that restricts the efficacy of coronary artery bypass grafting. Inhibition of vascular smooth muscle cells (VSMCs) proliferation can improve intimal hyperplasia and lumen stenosis. Irisin, a polypeptide secret...
Study on the mechanism of Shenling Baizhu powder on the pathogenesis of pregnancy complicated with non-alcoholic fatty liver, based on PI3K/AKT/mTOR signal pathway [0.03%]
基于PI3K/AKT/mTOR信号通路的参苓白术粉剂干预妊娠合并非酒精性脂肪肝病证机制研究
Yao Le,Zhijun Wang,Qian Zhang et al.
Yao Le et al.
This study investigates the effectiveness of Shenlin Baizhu powder in managing non-alcoholic fatty liver disease (NAFLD) during pregnancy and its mechanism through the PI3K/AKT/mTOR signaling pathway. Eight healthy male and 24 female Spragu...