Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells [0.03%]
通过清除衰老细胞缓解环磷酰胺引起的卵巢早衰
Huina Su,Ruiqiong Ma,Dehui Su et al.
Huina Su et al.
Alkylating agents, particularly cyclophosphamide (CY), are known for their high toxicity, which can lead to iatrogenic premature ovarian insufficiency (POI) and infertility in young cancer survivors. Currently, effective prevention and trea...
Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice [0.03%]
生酮饮食通过调控Uch-L1(C)改善阿尔茨海默病小鼠脑内能量代谢及认知功能
Nana Bao,Min Zhang,Ming Tang et al.
Nana Bao et al.
The ketogenic diet (KD), a high-fat, low-carbohydrate diet, can effectively regulate energy metabolism in the brain. The regulation of cerebral energy metabolism in patients with Alzheimer's disease (AD) has attracted the attention of resea...
Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model [0.03%]
电针联合rTMS通过DNMT1介导的PI3K-Akt通路促进脑瘫模型神经元再生
Juan Fan,Yu Ma,Liying Sun et al.
Juan Fan et al.
Cerebral palsy (CP), resulting from perinatal brain injury, is characterized by persistent motor dysfunction largely due to impaired regeneration of the corticospinal tract. Electroacupuncture (EA) and repetitive transcranial magnetic stimu...
Fabrizio De Luca
Fabrizio De Luca
Morphological analysis of neuronal processes and their networks is a key aspect of neuroscience, with relevance from basic research to clinical practice due to the central role of neuronal development and plasticity in many neurological dis...
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma [0.03%]
SRSF3通过促进XBP1s的产生来稳定自噬并增强胶质瘤的缺氧适应性
Bohu Liu,Xiaoran Zhang,Jintao Tian et al.
Bohu Liu et al.
Hypoxia is a key driver of glioblastoma (GBM) progression. Serine/arginine-rich splicing factor 3 (SRSF3) is associated with the malignant progression of GBM, but its role in the hypoxic microenvironment of GBM remains unclear. This study a...
Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation [0.03%]
cryptotanshinone通过调节Tregs / Th17细胞平衡和M1巨噬细胞活化来缓解小鼠DSS诱导的结肠炎
Lin Liu,Wei Huang,Yu Wu et al.
Lin Liu et al.
Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease has become a global disease in the 21st century, with increasing incidence rates in almost every industrialized country. Previous studies have suggested ...
Histopathological and immunofluorescent characterization of post-sepsis immune dysregulation in a clinically relevant mouse model [0.03%]
临床相关小鼠模型中脓毒症后免疫失调的组织病理学和免疫荧光特征分析
Haoran Tang,Chen Liao,Ning Tang et al.
Haoran Tang et al.
Sepsis remains a major cause of morbidity and mortality worldwide, yet its prolonged pathophysiological consequences are poorly understood. Here, we employed a murine cecal ligation and puncture (CLP) model to investigate the prolonged impa...
Immunohistochemical detection of putative pathogenetic factors in adhesions of infants: a pilot study [0.03%]
婴儿粘连中潜在致病因素的免疫组化检测：一项初步研究
Arvis Pauliņš,Anna Junga,Māra Pilmane
Arvis Pauliņš
Newborns' intestinal adhesions have been reported in 4.7% infants who underwent a laparotomy, but adhesions can also appear idiopathically. Etiology and pathogenesis of adhesions is still to be determined, but evidence shows relation to inf...
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway [0.03%]
GPER1过表达通过激活cAMP信号通路抑制食管癌生长
Hongmei Yin,Xiumei Han,Qun Zhang et al.
Hongmei Yin et al.
G protein-coupled estrogen receptor 1 (GPER1) has extensively verified as a tumor regulator in various types of cancers. However, its role in esophageal cancer (EC) remains largely unclear. In this study, the expression and prognostic predi...
Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study [0.03%]
低浓度臭氧促进移植物软骨的体外保存：超微结构研究
Giada Remoli,Chiara Rita Inguscio,Federico Boschi et al.
Giada Remoli et al.
Ozone (O3) is an oxidizing natural gas widely applied as adjunctive therapeutic treatment for a variety of pathological conditions. Currently, O3-based therapies rely on the low-dose concept i.e., the administration of low O3 concentrations...