Depot-dependent peroxisome response in the rat white adipose tissue under hypothyroidism [0.03%]
亚临床甲减小鼠白色脂肪组织中过氧化物酶体的响应机制研究
Ahsein Addloli,Marija Ilic,Tamara Zakic et al.
Ahsein Addloli et al.
The effect of thyroid hormones (TH) on metabolism and energy balance relies on their impact on lipid storage in adipose tissue (AT). Since peroxisomes play a key role in lipid metabolism in white AT, hypothyroidism may critically influence ...
Histopathological evaluation of RPL5 expression in triple-negative breast cancer: an integrated immunohistochemical and transcriptomic study [0.03%]
三阴性乳腺癌中RPL5表达的病理组织学评估：一项整合免疫组化和转录组的研究
Bing Zhao,Peiyuan Yu,Li Li et al.
Bing Zhao et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high invasiveness, limited therapeutic options, and unfavorable clinical outcomes. Ribosomal protein L5 (RPL5), a component of the large ribosom...
Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway [0.03%]
Lovastatin通过调节甲羟戊酸途径促进前列腺癌细胞铁死亡的机制研究
Yanhong Xiao,Zhengdao Liu,Yougang Feng et al.
Yanhong Xiao et al.
Prostate cancer (PCa) is a common malignancy in men with limited therapeutic options at advanced stages. Statins, widely prescribed lipid-lowering agents, have demonstrated antitumor activity in PCa, but underlying mechanisms are not fully ...
LncRNA RP11-708J19.2 promotes colorectal cancer progression by binding to SIRT7 via regulating H3K18ac [0.03%]
长链非编码RNA RP11-708J19.2通过调控H3K18ac促进结直肠癌进展
Jiali Ma,Xianglong Tian,Yiwen Qiu et al.
Jiali Ma et al.
Colorectal cancer (CRC) is a prevalent malignancy with a complex genetic basis. Recent genome-wide association studies (GWAS) have identified a susceptibility locus at 3p21.31, however, the functional SNP(s) underlying the association betwe...
Downregulation of GMPS inhibited the proliferation of hepatocellular cancer cells via the regulation of STAT3/c-Myc pathway [0.03%]
GMPS下调通过调节STAT3/c-Myc途径抑制肝癌细胞增殖
Zhibin Guo,Juan Yu,Jing Sun et al.
Zhibin Guo et al.
Hepatocellular cancer (HCC) is the sixth most common type of cancer worldwide. Guanosine monophosphate synthase (GMPS) participates in the regulation of chromatin and genes in various organisms, and is highly expressed in a number of human ...
Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling [0.03%]
TDAG51在PI3K-Akt信号通路介导的心肌梗死后血管生成和内皮重塑中的组织化学表征
Kaizheng Liu,Jinyu Pan,Quan Liu et al.
Kaizheng Liu et al.
Myocardial infarction (MI) triggers complex cardiac remodeling, including endothelial dysfunction, fibrosis, and angiogenesis. Characterizing the spatial distribution and cellular localization of regulatory molecules is critical for underst...
Elevated caspase 3 expression correlates with severe inflammation in Crohn's disease [0.03%]
Caspase 3表达升高与克罗恩病严重炎症相关
Nafie Sedju,Michael Naumann,Michael Vieth
Nafie Sedju
Caspase 3 is a key executioner of apoptotic cell death and contributes to intestinal epithelial homeodynamics. Apoptotic dysregulation has been implicated in Crohn's disease, yet data on caspase 3 expression across disease activity states r...
Astragaloside IV inhibits nasopharyngeal carcinoma progression by inhibiting SATB2/Wnt/PD-L1 pathway and enhancing the killing activity of T cells [0.03%]
黄芪IV通过抑制SATB2/Wnt/PD-L1信号通路并增强T细胞杀伤活性来抑制鼻咽癌进展
Yinping Zeng,Jiajun Huang,Tingting Duan et al.
Yinping Zeng et al.
Astragaloside IV (AS IV) inhibits the malignant phenotype of nasopharyngeal carcinoma (NPC), but whether its mechanism involves the regulation of immune checkpoint programmed cell death-ligand 1 (PD-L1) is not clear. Human NPC cells were tr...
SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway [0.03%]
SUSD2通过抑制PI3K/AKT/mTOR信号通路诱导自噬从而抑制肺腺癌的发生发展
Shengwen Wang,Gang Yang,Qian Zhang et al.
Shengwen Wang et al.
Lung adenocarcinoma (LUAD) is the most common and aggressive non-small cell lung cancer with limited therapeutic options. SUSD2 exhibits varying regulatory behaviors in different types of tumors, its role in LUAD remains unclear. This study...
Colchicine alleviates severe acute pancreatitis in rats by inhibiting acinar cell ferroptosis via LCN2/MAPK/ERK signaling axis [0.03%]
秋水仙碱通过LCN2/MAPK/ERK信号轴抑制急性重症胰腺炎中胰腺腺细胞铁死亡从而改善急性重症胰腺炎
Liu Yang,Xiaoyi Zheng,Yang Zhang et al.
Liu Yang et al.
Colchicine (COL) is known to ameliorate severe acute pancreatitis (SAP), yet the precise molecular mechanisms remain elusive. This study integrates bioinformatics with in vivo experimentation to elucidate the mechanism by which COL attenuat...