Fabrizio De Luca
Fabrizio De Luca
Morphological analysis of neuronal processes and their networks is a key aspect of neuroscience, with relevance from basic research to clinical practice due to the central role of neuronal development and plasticity in many neurological dis...
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma [0.03%]
SRSF3通过促进XBP1s的产生来稳定自噬并增强胶质瘤的缺氧适应性
Bohu Liu,Xiaoran Zhang,Jintao Tian et al.
Bohu Liu et al.
Hypoxia is a key driver of glioblastoma (GBM) progression. Serine/arginine-rich splicing factor 3 (SRSF3) is associated with the malignant progression of GBM, but its role in the hypoxic microenvironment of GBM remains unclear. This study a...
Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation [0.03%]
cryptotanshinone通过调节Tregs / Th17细胞平衡和M1巨噬细胞活化来缓解小鼠DSS诱导的结肠炎
Lin Liu,Wei Huang,Yu Wu et al.
Lin Liu et al.
Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease has become a global disease in the 21st century, with increasing incidence rates in almost every industrialized country. Previous studies have suggested ...
Histopathological and immunofluorescent characterization of post-sepsis immune dysregulation in a clinically relevant mouse model [0.03%]
临床相关小鼠模型中脓毒症后免疫失调的组织病理学和免疫荧光特征分析
Haoran Tang,Chen Liao,Ning Tang et al.
Haoran Tang et al.
Sepsis remains a major cause of morbidity and mortality worldwide, yet its prolonged pathophysiological consequences are poorly understood. Here, we employed a murine cecal ligation and puncture (CLP) model to investigate the prolonged impa...
Immunohistochemical detection of putative pathogenetic factors in adhesions of infants: a pilot study [0.03%]
婴儿粘连中潜在致病因素的免疫组化检测：一项初步研究
Arvis Pauliņš,Anna Junga,Māra Pilmane
Arvis Pauliņš
Newborns' intestinal adhesions have been reported in 4.7% infants who underwent a laparotomy, but adhesions can also appear idiopathically. Etiology and pathogenesis of adhesions is still to be determined, but evidence shows relation to inf...
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway [0.03%]
GPER1过表达通过激活cAMP信号通路抑制食管癌生长
Hongmei Yin,Xiumei Han,Qun Zhang et al.
Hongmei Yin et al.
G protein-coupled estrogen receptor 1 (GPER1) has extensively verified as a tumor regulator in various types of cancers. However, its role in esophageal cancer (EC) remains largely unclear. In this study, the expression and prognostic predi...
Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study [0.03%]
低浓度臭氧促进移植物软骨的体外保存：超微结构研究
Giada Remoli,Chiara Rita Inguscio,Federico Boschi et al.
Giada Remoli et al.
Ozone (O3) is an oxidizing natural gas widely applied as adjunctive therapeutic treatment for a variety of pathological conditions. Currently, O3-based therapies rely on the low-dose concept i.e., the administration of low O3 concentrations...
The hematopoietic stem cells supportive megakaryocytes as shapers of the bone marrow niche [0.03%]
造血干细胞支持性巨核细胞作为骨髓生态位的塑造者
Francesca Arciprete,Viola Velardi,Paola Verachi et al.
Francesca Arciprete et al.
The bone marrow (BM) niche plays a pivotal role in regulating the fate of hematopoietic stem cells (HSCs), and its integrity changes significantly during aging and in rare hematological disease, as in myelofibrosis (MF). In this study, we i...
Genetic deletion of P-selectin prevents fibrosis development by inhibiting the neutrophil megakaryocyte emperipolesis in the Gata1low mouse model for myelofibrosis [0.03%]
遗传删除P-选择素通过抑制Gata1低鼠髓系纤维化模型中中性粒细胞巨核细胞内吞作用来预防纤维化发展
Francesca Arciprete,Viola Velardi,Antonio Di Virgilio et al.
Francesca Arciprete et al.
Myelofibrosis (MF) is a rare chronic hematological disorder, within the family of myeloproliferative neoplasms. The MF patients present clinical abnormalities such as anemia, and thrombosis, as well as alterations in the bone marrow (BM) mi...
Transient receptor potential canonical 3/5 attenuate endothelial damage-induced neointima formation without affecting endothelial cell proliferation [0.03%]
瞬时受体电位香草素通道3/5通过抑制内皮损伤诱导的平滑肌细胞增殖抑制再狭窄形成而不影响内皮细胞增殖
Wenjun Zeng,Bei Liu,Lixia Yang et al.
Wenjun Zeng et al.
Store-operated calcium channels (SOCCs) are involved in the process of cell proliferation; however, their expression levels differ among cell types and information on their effects in different cells is lacking. This study aimed to compare ...