Downregulation of GMPS inhibited the proliferation of hepatocellular cancer cells via the regulation of STAT3/c-Myc pathway [0.03%]
GMPS下调通过调节STAT3/c-Myc途径抑制肝癌细胞增殖
Zhibin Guo,Juan Yu,Jing Sun et al.
Zhibin Guo et al.
Hepatocellular cancer (HCC) is the sixth most common type of cancer worldwide. Guanosine monophosphate synthase (GMPS) participates in the regulation of chromatin and genes in various organisms, and is highly expressed in a number of human ...
Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling [0.03%]
TDAG51在PI3K-Akt信号通路介导的心肌梗死后血管生成和内皮重塑中的组织化学表征
Kaizheng Liu,Jinyu Pan,Quan Liu et al.
Kaizheng Liu et al.
Myocardial infarction (MI) triggers complex cardiac remodeling, including endothelial dysfunction, fibrosis, and angiogenesis. Characterizing the spatial distribution and cellular localization of regulatory molecules is critical for underst...
Elevated caspase 3 expression correlates with severe inflammation in Crohn's disease [0.03%]
Caspase 3表达升高与克罗恩病严重炎症相关
Nafie Sedju,Michael Naumann,Michael Vieth
Nafie Sedju
Caspase 3 is a key executioner of apoptotic cell death and contributes to intestinal epithelial homeodynamics. Apoptotic dysregulation has been implicated in Crohn's disease, yet data on caspase 3 expression across disease activity states r...
Astragaloside IV inhibits nasopharyngeal carcinoma progression by inhibiting SATB2/Wnt/PD-L1 pathway and enhancing the killing activity of T cells [0.03%]
黄芪IV通过抑制SATB2/Wnt/PD-L1信号通路并增强T细胞杀伤活性来抑制鼻咽癌进展
Yinping Zeng,Jiajun Huang,Tingting Duan et al.
Yinping Zeng et al.
Astragaloside IV (AS IV) inhibits the malignant phenotype of nasopharyngeal carcinoma (NPC), but whether its mechanism involves the regulation of immune checkpoint programmed cell death-ligand 1 (PD-L1) is not clear. Human NPC cells were tr...
SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway [0.03%]
SUSD2通过抑制PI3K/AKT/mTOR信号通路诱导自噬从而抑制肺腺癌的发生发展
Shengwen Wang,Gang Yang,Qian Zhang et al.
Shengwen Wang et al.
Lung adenocarcinoma (LUAD) is the most common and aggressive non-small cell lung cancer with limited therapeutic options. SUSD2 exhibits varying regulatory behaviors in different types of tumors, its role in LUAD remains unclear. This study...
Colchicine alleviates severe acute pancreatitis in rats by inhibiting acinar cell ferroptosis via LCN2/MAPK/ERK signaling axis [0.03%]
秋水仙碱通过LCN2/MAPK/ERK信号轴抑制急性重症胰腺炎中胰腺腺细胞铁死亡从而改善急性重症胰腺炎
Liu Yang,Xiaoyi Zheng,Yang Zhang et al.
Liu Yang et al.
Colchicine (COL) is known to ameliorate severe acute pancreatitis (SAP), yet the precise molecular mechanisms remain elusive. This study integrates bioinformatics with in vivo experimentation to elucidate the mechanism by which COL attenuat...
Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells [0.03%]
通过清除衰老细胞缓解环磷酰胺引起的卵巢早衰
Huina Su,Ruiqiong Ma,Dehui Su et al.
Huina Su et al.
Alkylating agents, particularly cyclophosphamide (CY), are known for their high toxicity, which can lead to iatrogenic premature ovarian insufficiency (POI) and infertility in young cancer survivors. Currently, effective prevention and trea...
Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice [0.03%]
生酮饮食通过调控Uch-L1(C)改善阿尔茨海默病小鼠脑内能量代谢及认知功能
Nana Bao,Min Zhang,Ming Tang et al.
Nana Bao et al.
The ketogenic diet (KD), a high-fat, low-carbohydrate diet, can effectively regulate energy metabolism in the brain. The regulation of cerebral energy metabolism in patients with Alzheimer's disease (AD) has attracted the attention of resea...
Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model [0.03%]
电针联合rTMS通过DNMT1介导的PI3K-Akt通路促进脑瘫模型神经元再生
Juan Fan,Yu Ma,Liying Sun et al.
Juan Fan et al.
Cerebral palsy (CP), resulting from perinatal brain injury, is characterized by persistent motor dysfunction largely due to impaired regeneration of the corticospinal tract. Electroacupuncture (EA) and repetitive transcranial magnetic stimu...
Fabrizio De Luca
Fabrizio De Luca
Morphological analysis of neuronal processes and their networks is a key aspect of neuroscience, with relevance from basic research to clinical practice due to the central role of neuronal development and plasticity in many neurological dis...