Nuclear expression of AIRE in lung squamous cell carcinoma correlates with immune microenvironment remodeling and poor prognosis [0.03%]
AIRE核表达与肺鳞癌免疫微环境重塑及不良预后相关
Chengyan Wang,Chuhuai Wang,Yuhan Jia et al.
Chengyan Wang et al.
Objective: The autoimmune regulator (AIRE), an atypical transcriptional regulator, exhibits aberrant expression in multiple tumor types. However, its significance in lung squamous cell carcinoma (LUSC) is still uncertain....
Quality of life and sexual function after breast conservation surgery and mastectomy without reconstruction in South Indian patients [0.03%]
保乳手术与未行重建的乳房切除术对南印度患者的生活质量和性功能的影响
Silviya Jenifer,Sneha Raja,Narmatha Rajarathinam et al.
Silviya Jenifer et al.
Background: Breast cancer is a leading malignancy among women worldwide, significantly affecting physical, psychological, and sexual well-being. Surgical options such as breast conservation surgery (BCS) and mastectomy ha...
Patient-reported financial toxicity within Italian public healthcare system: A cross-sectional analysis in patients with cancer [0.03%]
意大利公共医疗保障体系下癌症患者的财务毒性调查：横断面分析
Anna Amela Valsecchi,Pamela Festa,Maria Laura Malgarini et al.
Anna Amela Valsecchi et al.
Purpose: The PROFFIT questionnaire was previously developed and validated, to assess financial toxicity (FT) in Italian patients with cancer. Here we describe FT in patients treated in a public Italian institution in 2024...
Choriocarcinoma: Diagnosis, treatment and management of a rare germ cell tumour. An update review [0.03%]
绒毛膜癌的诊断、治疗和管理：一项罕见生殖细胞肿瘤的综述更新研究
Pierantoni Francesco,Caliciotti Fabiana,Ahcene Djaballah Selma et al.
Pierantoni Francesco et al.
Choriocarcinoma is a malignant neoplasia which develops from trophoblastic cells. In males it is rare and often associated with other non-seminomatous germ cell tumours of the testis. Choriocarcinoma often presents with metastatic disease a...
The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis [0.03%]
体质指数对乳腺癌新辅助化疗疗效影响的系统评价和meta分析
Lirong Zhang,Dongmei Lu,Pan Geng et al.
Lirong Zhang et al.
Objective: Many studies have highlighted that elevated body mass index (BMI) not only correlates with an elevated likelihood of developing breast cancer (BC) but may also influence patients' responsiveness to therapeutic ...
Attitudes and beliefs of Italian palliative care experts regarding cachexia: A Delphi study [0.03%]
意大利缓和医疗专家对恶病质的态度及认知：德尔菲研究
Matteo Moroni,Eduardo Bruera,Luca Ghirotto et al.
Matteo Moroni et al.
Introduction: Cachexia is a multifactorial syndrome prevalent in advanced illness. Guidelines rarely integrate the relational, multidimensional perspective of palliative care (PC). Addressing this gap is essential to opti...
ALYREF promotes laryngeal cancer progression through a lactate-mediated lactylation feedback loop that enhances glycolysis [0.03%]
ALYREF通过乳酸介导的乳酰化反馈循环促进喉癌进展从而增强糖酵解
Shanyan Bian,Yingwei Guo,Rui Li et al.
Shanyan Bian et al.
Objective: As a serious malignancy of the head and neck region, laryngeal cancer (LC) exhibits active glycolysis that produces lactate, a metabolite capable of inducing protein lactylation. However, the role of lactate-in...
Forceful survivorship: The desire to procreate in parents of cancer patients [0.03%]
癌症患者父母的生育意愿：一种强韧的生存意志
Annarita Adduci,Giovanna Sironi,Andrea Ferrari et al.
Annarita Adduci et al.
Our study evaluated the desire to procreate of 96 mothers of children treated for cancer at the Pediatric Oncology Unit of Istituto Nazionale Tumori of Milan in 2021. Even at a time during which they fear losing the child they already have,...
Safety evaluation of selective RET inhibitors in patients with lung cancer: a real-world pharmacovigilance study [0.03%]
选择性RET抑制剂在肺癌患者中安全性的评价：一项基于真实世界药物警戒的研究
Yaokai Wang,Wenmei Jiang,Yun Cheng et al.
Yaokai Wang et al.
Objectives: Selpercatinib and pralsetinib are targeted therapies for non-small cell lung cancer. However, their adverse reaction profiles remain incompletely understood. This study aims to evaluate the post-marketing adve...
Digital workload in oncology trials: A comparative analysis of e-portal usage and operational insights from a single-center experience [0.03%]
肿瘤试验的数字工作量：单一中心电子平台使用情况及运营见解的比较分析
Stefano Stabile,Sara Mariano,Anna Bombelli et al.
Stefano Stabile et al.
Background: The digitalization of clinical research has increased reliance on electronic portals (e-portals), with significant implications for trial site operations. Our aim is to map the types and number of e-portals re...