Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment [0.03%]
下一代抗CD20单克隆抗体在自身免疫性疾病治疗中的应用
Fanny Huynh Du,Elizabeth A Mills,Yang Mao-Draayer
Fanny Huynh Du
The clinical success of anti-CD20 monoclonal antibody (mAb)-mediated B cell depletion therapy has contributed to the understanding of B cells as major players in several autoimmune diseases. The first therapeutic anti-CD20 mAb, rituximab, i...
Personalized medicine in rheumatology: the paradigm of serum autoantibodies [0.03%]
风湿病学的个性化医疗：血清自身抗体的典范
Silvia Sirotti,Elena Generali,Angela Ceribelli et al.
Silvia Sirotti et al.
The sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite identical genotypes, as well illustr...
Chemiluminescent immunoassay technology: what does it change in autoantibody detection? [0.03%]
化学发光免疫技术在自身抗体检测中的应用及意义
Luigi Cinquanta,Desré Ethel Fontana,Nicola Bizzaro
Luigi Cinquanta
Diagnostic technology is rapidly evolving, and over the last decade, substantial progress has been made even for the identification of antibodies, increasingly approaching this type of diagnostic to that of automated clinical chemistry labo...
Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods [0.03%]
依据临床化学和生物医学实验室科学基金会指南定义抗甲状腺球蛋白抗体的正常参考上限：十一种不同自动化方法的比较
F D&#x;Aurizio,P Metus,A Ferrari et al.
F D&#x;Aurizio et al.
Purpose: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence...
Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice [0.03%]
红细胞带3蛋白特异肽诱导IL-10细胞因子产生及对T淋巴细胞增殖的抑制作用以及这些肽在NZB鼠自身免疫性溶血性贫血中的作用
Abdel-Rahman Youssef,Christopher J Elson
Abdel-Rahman Youssef
Purpose: The anion channel protein band 3 is the main target of the pathogenic red blood cells (RBC) autoantibodies in New Zealand black (NZB) mice. CD4 T cells from NZB mice with autoimmune hemolytic anemia respond to ba...
A case of sarcoidosis with isolated hepatosplenic onset and development of inflammatory bowel disease during recovery stage [0.03%]
一例以孤立肝脾发病并伴有病情恢复期发生炎症性肠病的Wisdemann型狼疮患者
Moris Sangineto,Chiara Valentina Luglio,Patrizia Suppressa et al.
Moris Sangineto et al.
Sarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system...
Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies [0.03%]
抗磷脂抗体患者血浆中磷脂酰胆碱卵磷脂酰蛋白酶活性的测定研究
Martina Fabris,Adriana Cifù,Cinzia Pistis et al.
Martina Fabris et al.
Purpose: To explore the role of plasmatic platelet-activating factor acetylhydrolase (PAF-AH), a marker of cardiovascular risk, in patients with anti-phospholipid antibodies (aPL). ...
The universe of ANA testing: a case for point-of-care ANA testing [0.03%]
ANA检测的体外诊断试剂研发及应用现状与挑战——POCT ANA检测初探
Konstantin N Konstantinov,Robert L Rubin
Konstantin N Konstantinov
Testing for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune ...
Analysis of DFS70 pattern and impact on ANA screening using a novel HEp-2 ELITE/DFS70 knockout substrate [0.03%]
新型HEP-2 ELITE/DFS70基因敲除底物的DFS70蛋白斑图分析及其对ANA筛查的影响研究
Kishore Malyavantham,Lakshmanan Suresh
Kishore Malyavantham
Indirect immunofluorescence (IIF) using human epithelial cell (HEp-2) substrate is a widely used and the recommended method for screening of antinuclear antibodies (ANA). Dense fine speckled (DFS70) pattern on HEp-2 has been widely reported...
Ricardo Núñez Miguel,Jane Sanders,Jadwiga Furmaniak et al.
Ricardo Núñez Miguel et al.
Purpose: The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves' disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cle...