Sander H J van Dooren,Walther J van Venrooij,Ger J M Pruijn
Sander H J van Dooren
In recent years, the detection and characterization of (novel) autoantibodies is becoming increasingly important for the early diagnosis of autoimmune diseases. The idiopathic inflammatory myopathies (IIM, also indicated with myositis) are ...
Pearls in autoimmunity [0.03%]
自身免疫中的精华研究
Jozélio Freire de Carvalho,Rosa Maria Rodrigues Pereira,Yehuda Shoenfeld
Jozélio Freire de Carvalho
This manuscript does a review of the more frequent issues published at Autoimmunity Reviews, Journal of Autoimmunity and Autoimmunity in the period of January-December 2009. The following topics were commented: (1) multiple sclerosis (MS) a...
Accuracy of receptor-based methods for detection of thyrotropin-receptor autoantibodies: a new automated third-generation immunoassay shows higher analytical and clinical sensitivity for the differential diagnosis of hyperthyroidism [0.03%]
受体方法检测促甲状腺激素受体自身抗体的准确性：一个新的自动化第三代免疫测定法对高甲状腺素症的鉴别诊断具有更高的分析和临床敏感性
Renato Tozzoli,Graziano Kodermaz,Danilo Villalta et al.
Renato Tozzoli et al.
Purpose: Specific autoantibodies acting as TSH receptor agonists (TRAb) are responsible for Graves' disease (GD). In the last 30 years three generations of assay methods for the detection of TRAb have become available. Th...
Serum levels of anti-CCP antibodies, anti-MCV antibodies and RF IgA in the follow-up of patients with rheumatoid arthritis treated with rituximab [0.03%]
使用利妥昔单抗治疗的类风湿性关节炎患者的随访过程中抗CCP抗体，抗MCV抗体和RF IgA的血清水平
Martina Fabris,Salvatore De Vita,Nadia Blasone et al.
Martina Fabris et al.
Rheumatoid arthritis (RA) is characterized by the presence of circulating rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA), which are positive in about 70-80% of patients. APCA have a higher specificity and therefore a...
Diagnostic sensitivity of thyroid autoantibodies assessed in a population-based, cross-sectional study in adults [0.03%]
成人中甲状腺自身抗体诊断敏感性的横断面人群研究
Emanuele Bosi,Roberto Bianchi,Giacomo Ruotolo et al.
Emanuele Bosi et al.
The aim of this study was to estimate the diagnostic sensitivity of thyroid autoantibodies in individuals with a case-mix of subjects with thyroid disease representing that of the general population. We measured thyroid microsome (TMA), thy...
The soluble CTLA-4 receptor and its role in autoimmune diseases: an update [0.03%]
可溶性CTLA-4受体及其在自身免疫性疾病中的作用：最新进展
Daniele Saverino,Rita Simone,Marcello Bagnasco et al.
Daniele Saverino et al.
CTLA-4, initially described as a membranebound molecule, is a costimulatory receptor transducing a potent inhibitory signal. Increasing evidence shows the CTLA-4 gene to be an important susceptibility locus for autoimmune endocrinopathies a...
Protective molecules and their cognate antibodies: new players in autoimmunity [0.03%]
保护性分子及其相应的抗体：自身免疫中新的参与者
Margherita Zen,Nicola Bassi,Carla Campana et al.
Margherita Zen et al.
Impairment of the clearance of apoptotic material seems to contribute to autoantigen exposure, which can initiate or maintain an autoimmune response in predisposed individuals. Complement component C1q, Creactive protein (CRP), serum amyloi...
Adult-onset Still disease: a rare disorder with a potentially fatal outcome [0.03%]
成人型Still病：一种罕见但可能危及生命的疾病
Roberta Priori,Serena Colafrancesco,Angelica Gattamelata et al.
Roberta Priori et al.
Purpose: The aim of this study was to assess the clinical and laboratory features of a cohort of Italian patients with adult-onset Still disease (AOSD) with particular attention on possible life-threatening complications....
Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis [0.03%]
调节T细胞在类风湿性关节炎中的作用：事实与假设
Alessia Alunno,Elena Bartoloni,Giuseppe Nocentini et al.
Alessia Alunno et al.
Regulatory T cells (Treg) are a CD4(+) lymphocyte subset involved in self-tolerance and autoimmunity prevention. There is evidence for a phenotypic and/or functional impairment of this cell subset during the natural history of several chron...
Twenty-eight years with antineutrophil cytoplasmic antibodies (ANCA): how to test for ANCA - evidence-based immunology? [0.03%]
抗中性粒细胞胞浆抗体(ANCA)二十八年：如何检测ANCA-基于证据的免疫学？
Elena Csernok,Julia U Holle
Elena Csernok
Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and primary pauci-immune crescentic glomerulonephritis are associated with circulating antineutrophil cytoplasmic autoantibodies (ANCA) (collectively called ANCA-as...