Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity [0.03%]
亚洲糖蛋白受体(ASGPR)：肝脏特异性自身免疫的特殊靶点
Dirk Roggenbuck,Maria G Mytilinaiou,Sergey V Lapin et al.
Dirk Roggenbuck et al.
Asialoglycoprotein receptor (ASGPR) autoantibodies have been considered specific markers of autoimmune hepatitis (AIH). The exact mechanisms responsible for the development of these autoantibodies and leading to autoimmunity to this peculia...
Recurrence of autoimmune liver diseases after liver transplantation: clinical aspects [0.03%]
肝移植后自身免疫性肝脏疾病的复发：临床方面
Evangelos Cholongitas,Andrew K Burroughs
Evangelos Cholongitas
Autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis are autoimmune liver diseases characterized by progressive immune-mediated inflammation leading to the destruction of the hepatocytes and the biliary epithel...
Predicting and preventing autoimmunity: the case of anti-mitochondrial antibodies [0.03%]
预测和预防自身免疫性疾病：以抗线粒体抗体为例
Malgorzata Milkiewicz,Llorenç Caballería,Daniel S Smyk et al.
Malgorzata Milkiewicz et al.
To be able to predict who will develop autoimmune disease would allow for early treatment which may dramatically alter the course of the disease. In some cases, it may also lead to prevention of the disease development. The prediction of di...
Popular and unpopular infectious agents linked to primary biliary cirrhosis [0.03%]
原发性胆汁性肝硬化相关的受欢迎和不受欢迎的传染因子
Andreas L Koutsoumpas,Stephen Kriese,Eirini I Rigopoulou
Andreas L Koutsoumpas
Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the autoimmune destruction of the biliary epithelial cells of the small and medium-size bile ducts. The disease affects middle aged women and usuall...
The immunopathogenetic role of autoantibodies in canine autoimmune hepatitis: lessons to learn from human autoimmune hepatitis [0.03%]
犬自身免疫性肝炎中自身抗体的免疫病理作用：从人类自身免疫性肝炎中吸取的教训
Christos Liaskos,Athanasios Mavropoulos,Timoklia Orfanidou et al.
Christos Liaskos et al.
Autoimmune hepatitis (AIH) is not a disease entity restricted to man, but it can be found in other animals including canines. An increasing number of studies have focused on the immunopathogenesis of human autoimmune hepatitis (hAIH), but l...
Characterization for anti-cytoplasmic antibodies specificity by morphological and molecular techniques [0.03%]
形态和分子技术对抗细胞质抗体特异性的鉴定
Claudia Alpini,Milvia Lotzniker,Serenella Valaperta et al.
Claudia Alpini et al.
Purpose: The aim of our study was the characterization of anti-cytoplasmic antibodies by home-made morphological and biochemical techniques. Indeed, indirect immunofluorescence (IIF) on HEp-2 cell line is not always exhau...
The immunofluorescence techniques in the diagnosis of endocrine autoimmune diseases [0.03%]
免疫荧光技术在内分泌自身免疫性疾病诊断中的应用
Corrado Betterle,Renato Zanchetta
Corrado Betterle
In the study of autoimmune diseases, the laboratory plays a very important role. We describe the immunofluorescence techniques (direct, indirect, complement-fixing, double) for determining the presence of autoantibodies and their role in th...
Automation in indirect immunofluorescence testing: a new step in the evolution of the autoimmunology laboratory [0.03%]
间接免疫荧光试验的自动化：自身免疫学实验室发展的新一步
Renato Tozzoli,Antonio Antico,Brunetta Porcelli et al.
Renato Tozzoli et al.
Indirect immunofluorescence (IIF) plays an important role in immunological and immunometric assays for detecting and measuring autoantibodies. This technology was the first multiplex method used to detect cardinal autoantibodies for the dia...
Toward a new autoantibody diagnostic orthodoxy: understanding the bad, good and indifferent [0.03%]
走向新的自身抗体诊断标准：理解好坏与无关紧要
Marvin J Fritzler
Marvin J Fritzler
Rapid advances in diagnostic technologies used to detect autoantibodies have made it difficult for even the most modern laboratory to keep abreast of the changing approaches and platforms, not to mention the clinicians who are hard pressed ...
Missing links in high quality diagnostics of inflammatory systemic rheumatic diseases: It is all about the patient! [0.03%]
炎症性全身性风湿病高质量诊断中的缺失环节：一切都关乎患者！
Allan S Wiik,Nicola Bizzaro
Allan S Wiik
The aim of this review is to focus attention on high quality diagnostics of systemic inflammatory rheumatic diseases. Though many steps in the diagnostic process from the first visit in a doctor's office till a final diagnosis have been est...