Exercise-Induced Lactate Is Associated with the Modulation of Mitophagy and Ferroptosis and Reduced Amyloid-Beta and Tau in Type 2 Diabetes [0.03%]
运动诱导的乳酸与线粒体自噬和铁死亡调节及Ⅱ型糖尿病小鼠脑内淀粉样蛋白-β和tau减少有关
Pouria Khosravi,Fereshteh Shahidi,Arezoo Eskandari et al.
Pouria Khosravi et al.
Background: Type 2 diabetes (T2D) is associated with increased oxidative stress, impaired mitophagy, enhanced ferroptosis, and the accumulation of amyloid beta (Aβ) and hyperphosphorylated tau in the hippocampus. Exercis...
Expression of Epithelial-Mesenchymal Transition-Related Genes in Primary Brain Tumors [0.03%]
原发性脑肿瘤中上皮间质转化相关基因的表达
Shiva Bayat,Negar Mousavi,Fatemeh Vand-Rajabpour et al.
Shiva Bayat et al.
Background: Gliomas are the most common malignant primary brain tumors in adults. Meningiomas, on the other hand, are benign primary brain tumors treated by surgical resection. Epithelial-to-mesenchymal transition (EMT), ...
Quercetin and 5-Fluorouracil Synergistically Suppress ZEB1 and Restore Epithelial Integrity in Triple-Negative Breast Cancer [0.03%]
槲皮素和氟尿嘧啶协同抑制三阴性乳腺癌中的ZEB1并恢复上皮完整性
Leila Nejat,Mahdi Hatami,Maryam Adelipour et al.
Leila Nejat et al.
Background: Triple-negative breast cancer (TNBC) remains a therapeutic challenge due to its metastatic features and resistance to conventional therapies. This study investigated the synergistic potential of quercetin (QC)...
Hamidreza Saber,Zahra Mousavipour
Hamidreza Saber
Adenoviral vectors (AdVs) represent one of the most extensively researched platforms in the realm of gene therapy, providing advantages such as high transduction efficiency, large transgene capacity, and broad tropism. This review provides ...
Bacteroides thetaiotaomicron and Human Health: A Bibliometric Analysis of Global Research Trends [0.03%]
拟杆菌和人类健康：全球研究趋势的计量分析
Farzaneh Hasanian-Langroudi,Mehdi Hedayati,Farzad Esmaeili et al.
Farzaneh Hasanian-Langroudi et al.
Bacteroides thetaiotaomicron is a highly abundant Gram-negative anaerobic bacterium that plays a crucial role in maintaining intestinal homeostasis and modulating intestinal diseases. A bibliometric study was conducted to examine global pub...
Extracellular Vesicles-Derived MicroRNAs: Emerging Game Changers in Cancer Pathogenesis and Therapeutic Response [0.03%]
细胞外囊泡衍生的微小RNA：在癌症发病机制和治疗反应中的新兴游戏规则改变者
Faezeh Maroufi,Amirali Ebrahimpour,Fatemeh Davami
Faezeh Maroufi
Effective communication between cells is a fundamental feature of multicellular organisms, occurring through direct contact or the transfer of secreted molecules. Among these mediators, extracellular vesicles (EVs) function as biological me...
Targeting Metabolic Pathways in AML Cell Lines: Impact of Hypoxia-Inducible Factor-1α (HIF-1α) and Lactate Dehydrogenase-A (LDH-A) Inhibition [0.03%]
靶向代谢途径在急性髓系白血病细胞系中的作用：缺氧诱导因子-1α（HIF-1α）和乳酸脱氢酶A（LDH-A）抑制的影响
Amir Kahrizi,Hossein Asgarian-Omran,Saeid Taghiloo et al.
Amir Kahrizi et al.
Introduction: The Warburg effect is considered one of the most important metabolic alterations in tumor cells. While extensively studied in solid tumors, the role of this effect in acute myeloid leukemia (AML) is less def...
Potential of Stevia rebaudiana Bertoni Aquatic Extract in Treating Diabetes-Induced Infertility: Effects on Autophagy and Apoptosis [0.03%]
Stevia rebaudiana Bertoni 水提物在治疗糖尿病性不育方面的潜力：对自噬和凋亡的影响
Mozhdeh Zamani,Farhad Koohpeyma,Alireza Raeisi et al.
Mozhdeh Zamani et al.
Background: Infertility is one of the major complications of diabetes. Diabetic-mediated oxidative stress could destroy autophagy in testes, leading to damaged sperm and male infertility. Stevia rebaudiana Bertoni is a me...
Transcriptional Control of PI3K/AKT/mTOR by piRNA-651 in Breast Carcinoma [0.03%]
piRNA-651通过PI3K/AKT/mTOR途径转录调控乳腺癌
Sena Köstü,Baturalp Bakırcı,Ece Bilge Şimşek et al.
Sena Köstü et al.
Background: Breast cancer (BC) is among the most prevalent malignancies in women worldwide, yet early diagnosis is associated with a high survival rate. The proliferation of BC is linked to the overexpression of genes wit...
Engineering a Potent Anti-MRSA Agent: The Development and Characterization of Chimeric Endolysin ZAM-MSC [0.03%]
工程获得的一种强力抗MRSA制剂：嵌合内溶酶ZAM-MSC的开发与特性分析
Atefeh Noori,Zahra Amini-Bayat,Saeed Mirdamadi et al.
Atefeh Noori et al.
Background: The increasing prevalence of S. aureus, especially methicillin-resistant strains, poses a major healthcare threat due to limited therapies. To address this challenge, we engineered the chimeric endolysin ZAM-M...