Optimal Extraction and Deproteinization Method for Mannoprotein Purification from Kluyveromyces marxianus [0.03%]
Kluyveromyces marxianus 甘露蛋白的优化提取及脱蛋白方法
Ashraf Hajhosseini,Anousheh Sharifan,Zohreh Eftekhari et al.
Ashraf Hajhosseini et al.
Background: Mannoproteins, mannose-glycosylated proteins, play an important role in biological processes and have various applications in industries. Several methods have been already used for the extraction of mannoprote...
Engineering a CEACAM1 Variant with the Increased Binding Affinity to TIM-3 Receptor [0.03%]
工程构建增强与TIM-3受体亲和力的CEACAM1变异型蛋白质
Zahra Hajihassan,Mehran Mohammadpour Saray,Aysan Yaseri
Zahra Hajihassan
Background: T-cell immunoglobulin domain and mucin domain-3 (TIM-3) is an inhibitory receptor expressed in a variety of cells, including dendritic cells, T-helper 1 lymphocytes, and natural killer cells. Binding of this p...
Rel-A/PACER/miR 7 Axis May Play a Role in Radiotherapy Treatment in Breast Cancer Patients [0.03%]
Rel-A/PACER/miR-7轴可能在乳腺癌患者的放射治疗中发挥作用
Shokri Fazlollah,Mozdarani Hossein,Omrani Mir Davood
Shokri Fazlollah
Background: Radiotherapy has become the standard form of treatment for breast cancer (BC). Radioresistance is an issue that limits the effectiveness of radiotherapy (RT). Therefore, predictive biomarkers are needed to cho...
Sara Ansari,Sedighe Kolivand,Sara Salmanian et al.
Sara Ansari et al.
Background: The canonical Wnt signal transduction or the Wnt/β-catenin pathway plays a crucial role in both carcinogenesis and development of animals. Activation of the Gαq class of Gα proteins positively regulates Wnt...
Effect of miR-4270 Suppression on Migration in Hepatocellular Carcinoma Cell Line (HepG2) [0.03%]
抑制miR-4270对肝癌细胞系HepG2迁移能力的影响
Hassan Akrami,Hanieh Gholami,Mohammad Reza Fattahi et al.
Hassan Akrami et al.
Background: Liver transplantation and surgical resection are two major strategies for treatment of hepatocellular carcinoma (HCC) patients. One approach to treating HCC is the suppression of metastasis to other tissues. H...
Comparison of Isoenzyme Pattern of Echinococcus granulosus sensu stricto (G1-G3) and E. canadensis (G6/G7) Protoscoleces [0.03%]
细粒棘球绦虫（G1-G3）和加拿大棘球绦虫（G6/G7）原头节异构酶谱的比较分析研究
Majid Dousti,Seyed Mahmoud Sadjjadi,Rahmat Solgi et al.
Majid Dousti et al.
Background: Different genotypes of Echinococcus granulosus sensu lato (s.l.) infect humans and ungulate animals, causing cystic echinococcosis. Simultaneous isoenzyme, as well as molecular characterizations of this parasi...
Trastuzumab Charge Variants: a Study on Physicochemical and Pharmacokinetic Properties [0.03%]
曲妥珠单抗电荷异构体：物理化学及药代动力学性质研究
Fatemeh Torkashvand,Mahsa Mehranfar,Mahsa Rashidi Gero et al.
Fatemeh Torkashvand et al.
Background: Post-translational modifications in bioprocessing and storage of recombinant mAbs are the main sources of charge variants. While the profile of these kinds of variants is considered an important attribute for ...
K-Ras4A Plays a More Significant Role than K-Ras4B in Ductal Carcinoma of Breast [0.03%]
K-Ras4A在乳腺导管癌中的作用较K-Ras4B更为重要
Mohamad Mahdi Mortazavipour,Zeinab Mohamadalizadeh-Hanjani,Loabat Geranpayeh et al.
Mohamad Mahdi Mortazavipour et al.
Background: K-Ras mutations rarely occur in breast cancer. However, studies have supported that K-Ras upregulation is involved in breast cancer pathogenesis. Two main K-Ras transcript variants; K-Ras4A and K-Ras4B, origin...
Synthesis and Characterization of Thymol-Loaded Niosomal Film for the Prevention of Implant-Related Infection [0.03%]
薄荷醇载药尼油质膜的合成与表征用于预防植入物相关感染
Raziyeh Najafloo,Rana Imani,Mahla Behyari et al.
Raziyeh Najafloo et al.
Background: Infection is one of the significant challenges in medical implant-related surgeries. Despite systemic antibiotic therapies, bacterial growth after implantation may cause implant failure. Nowadays, unlike the s...
Effect of Mir-4270 Inhibitor and Mimic on Viability and Stemness in Gastric Cancer Stem-Like Cells Derived from MKN-45 Cell Line [0.03%]
Mir-4270抑制剂和模拟物对MKN-45细胞系诱导的胃癌干细胞样细胞活力及干性的影响
Hassan Akrami,Seyedeh Azra Shamsdin,Yousef Nikmanesh et al.
Hassan Akrami et al.
Background: MicroRNAs (miRNAs) are significant regulatory factors in stem cell proliferation, and change in miRNA expression influences the cancer stem cell viability and gene expression. Herein, we evaluated the effect o...