Fyn kinase mediates the development of rats with chronic obstructive pulmonary disease by modulating the activation of p38 MAPK and NF-κB [0.03%]
Fyn激酶通过调节p38MAPK和NF-κB的活化介导慢性阻塞性肺疾病大鼠模型的发展
Qiangqiang Chu,Yan-Bei Zhang,Nan Shen et al.
Qiangqiang Chu et al.
Objectives: The current research was conducted to study the function of Fyn in a rat model of chronic obstructive pulmonary disease (COPD). Materials and ...
Voluntary exercise alleviates ischemic brain injury in mice by modulating mitochondrial dysfunction [0.03%]
自愿锻炼通过调节线粒体功能障碍来缓解小鼠缺血性脑损伤
Beibei Li,Ye Zhou,Guifen Yang et al.
Beibei Li et al.
Objectives: The relationship between exercise and mitochondrial function is unclear. This study investigated the relationship between voluntary exercise and mitochondrial dynamics in ischemic stroke model mice. ...
Exploring the role of curcumin, nanocurcumin, and a PPAR agonist in preventing paraquat-induced systemic inflammation and oxidative stress in rats [0.03%]
姜黄素、纳米姜黄素及PPAR激动剂干预阻断百草枯致大鼠全身性炎症反应和氧化应激的小鼠实验研究
Mahboobeh Ghasemzadeh Rahbardar,Mohammad Ehsan Taghavizadeh Yazdi,Sima Beigoli et al.
Mahboobeh Ghasemzadeh Rahbardar et al.
Objectives: We investigated the effects of curcumin, nanocurcumin, and pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) activator, on the systemic inflammation and oxidative stress induced by inha...
Schisandrin B regulates the SIRT1/PI3K/Akt signaling pathway to ameliorate Ang II-infused cardiac fibrosis [0.03%]
Schisandrin B通过调节SIRT1/PI3K/Akt信号通路改善血管紧张素II诱导的心脏纤维化
Xiaogang Zhang,Mengqing Shi,Zhongying Xing et al.
Xiaogang Zhang et al.
Objectives: Schisandrin B (SchB), extracted from Schisandra chinensis, has antimicrobial and anti-inflammatory effects. The study aimed to investigate SchB's possible defense against angiotensin II (Ang II)-infused cardia...
The ameliorative effects of hesperidin in rats developed hepatotoxicity with deltamethrin [0.03%]
柚皮素对高效氯氰菊酯所致肝毒性大鼠的改善作用研究
Seda Cetinkaya Karabekir,Mehmet Enes Sozen,Ilknur Cinar Ayan et al.
Seda Cetinkaya Karabekir et al.
Objectives: Deltamethrin (DLM) is a widely used insecticide in agriculture; however, exposure to it can lead to serious health problems. This study aimed to evaluate the protective effects of hesperidin (HSP), a natural a...
Cinnamaldehyde ameliorates obesity-induced nephropathy in C57BL/6 mice via modulation of AMPK/ACC and NF-kB pathways [0.03%]
肉桂醛通过调节AMPK/ACC和NF-κB途径改善C57BL/6小鼠的肥胖相关性肾病
Himani Gupta,Uma Bhandari
Himani Gupta
Objectives: Chronic kidney disease (CKD) is a life-threatening condition often resulting from obesity and other pathologies. The present study assesses the nephroprotective effect of Cinnamaldehyde against high-fat diet (...
Troxerutin alleviates hepatorenal toxicity induced by carbon tetrachloride in male mice [0.03%]
芸香苷缓解四氯化碳致小鼠肝肾毒性的作用研究
Elham Hakimizadeh,Ayat Kaeidi,Iman Fatemi et al.
Elham Hakimizadeh et al.
Objectives: Troxerutin (TRX) is a natural bioflavonoid with several medicinal properties. We assessed its protective effect on carbon tetrachloride-related hepatorenal damage in male mice. ...
Daidzein improves neuronal health and alleviates inflammation and apoptosis through BDNF and estrogen receptors in the hippocampus of ovariectomized rats [0.03%]
大豆异黄酮染料木素通过海马体中的脑源性神经营养因子和雌激素受体改善神经健康并减轻卵巢切除大鼠的炎症和细胞凋亡
Asma Neisy,Zahra Khoshdel,Farhad Koohpeyma et al.
Asma Neisy et al.
Objectives: Isoflavone Daidzein (DDZ) has emerged as a promising alternative to hormone replacement therapy (HRT) for ameliorating estrogen deficiency (ED). However, the stereological and molecular mechanism of its effect...
The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways [0.03%]
通过靶向各种信号通路在神经性疾病中研究柚皮素和芸香苷的神经保护作用
Nikoo Abharian,Noushin Nikray,Afsoon Feizi et al.
Nikoo Abharian et al.
Diosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations,...
Mohsen Imenshahidi,Mona Kabiri,Mohammad Jandaghi et al.
Mohsen Imenshahidi et al.
Objectives: Insulin therapy is critical in diabetic patients for controlling blood glucose levels. In recent years, pulmonary insulin delivery has emerged as an alternative approach for overcoming the therapeutic disadvan...