Neural progenitor cell transplantation results in structural and functional recovery in a rat model of cerebral palsy [0.03%]
神经祖细胞移植可改善脑瘫模型大鼠的结构和功能损伤
Maryam Tavakoli Lakeh,Seyed Massood Nabavi,Fatemeh Rouhollah et al.
Maryam Tavakoli Lakeh et al.
Objectives: Cerebral palsy (CP) is the most prevalent pediatric neurodevelopmental disorder. Stem cell therapy is a promising way to treat brain disorders, including CP. This study sought to establish a model using pregna...
Anemoside B4 mitigates endoplasmic reticulum stress-induced apoptosis post cerebral ischemia/reperfusion injury in rats [0.03%]
风药B4缓解缺血再灌注损伤后大鼠内质网应激诱导的细胞凋亡
Xiaohuan Huang,Ran Deng,Chaoyue Ma et al.
Xiaohuan Huang et al.
Objectives: Anemoside B4 (AB4) exhibits neuroprotective effects on cerebral ischemia/reperfusion injury (CIRI), and endoplasmic reticulum stress (ERS) plays a crucial role in the process of CIRI. Nevertheless, it remains ...
Synergistic anticancer effect of CDRI-08 and abiraterone acetate against castration resistant prostate cancer targeting PI3K/Akt pathway [0.03%]
CDRI-08和阿比特龙醋酸盐针对PI3K/Akt途径协同治疗去势抵抗性前列腺癌的抗肿瘤效果
Bhavana Jonnalagadda,Sumathy Arockiasamy
Bhavana Jonnalagadda
Objectives: There is a considerable interest in combination therapy targeting the complex interlinked pathways in prostate cancer due to the development of drug resistance with monotherapies. A standardized fraction of Ba...
Expression of toll-like receptors and inflammatory mediators in primary human glioma cells (low- and high-grade) compared to primary cells from epileptic human brain [0.03%]
与人类癫痫脑组织原代细胞相比的人胶质母细胞瘤原代细胞（低级别和高级别）中 toll 样受体及炎症介质的表达
Negin Masoomabadi,Safieh Ebrahimi,Farshid Noorbakhsh et al.
Negin Masoomabadi et al.
Objectives: Toll-like receptors (TLRs) have been implicated in the pathogenesis of glioma as principal regulators of inflammation and innate immune function. Considering the heterogeneous nature of gliomas, ranging from l...
Ketone body, as an emerging modulator of metabolic reprogramming and epigenetics in breast cancer [0.03%]
酮体作为乳腺癌代谢重编程和表观遗传学的新兴调节因子
Fatemeh Mehdikhani,Sadegh Rajabi,Maryam Mohammadlou et al.
Fatemeh Mehdikhani et al.
The metabolic profile of cancer cells, notably their reliance on glucose as a primary energy source for proliferation, sets them apart from normal cells. This metabolic dependency may significantly affect their invasive potential when an ad...
Azithromycin prevents implantation failure via up-regulation of leukemia inhibitory factor in endotoxemic pregnant rats [0.03%]
阿奇霉素可通过上调内毒素血症性妊娠大鼠子宫LIF mRNA水平来预防着床失败
Gonca Sonmez,Oznur Tufan Akarslan,Muhammed Hudai Culha et al.
Gonca Sonmez et al.
Objectives: Embryonic implantation is a complex and poorly understood process in which numerous cellular, hormonal, and molecular factors play critical roles. Infections in this process can result in pregnancy failure, su...
Therapeutic potential of magnesium sulfate in improving duodenal homeobox 1 and PPARG coactivator 1 alpha genes to reduce pancreatic insulin resistance in F1 offspring of diabetic rats [0.03%]
硫酸镁通过改善杜氏回肠嗜铬样homeobox 1及过氧化物酶体增殖活化受体共激活因子α基因表达降低糖尿病大鼠F1代胰岛素抵抗的治疗潜力研究
Mahtab Ghanbari Rad,Hossein Rezazadeh,Mohammadreza Sharifi et al.
Mahtab Ghanbari Rad et al.
Objectives: The study aimed to investigate the role of magnesium sulfate (MgSO4) therapy in pancreatic insulin resistance (IR) in diabetic and non-diabetic rats and their F1 offspring following administration of a high-fa...
Adipose stem cell-derived exosomes circular RNA circFryl attenuate atrial fibrosis and cardiomyocyte apoptosis in atrial fibrillation [0.03%]
脂肪干细胞衍生的外泌体环状RNA circFryl在房颤中通过减轻心房纤维化和心肌细胞凋亡发挥作用
Chunpu Li,Jiuting Tan,Xintao Deng
Chunpu Li
Objectives: Atrial fibrillation (AF) is a prevalent arrhythmia accompanied by structural and electrical remodeling of the heart. Here, we examined the possible mechanisms behind the protective role of adipose-derived stem...
Herbal medicine approach to relieving dyspnea: A narrative review of efficacy and mechanisms [0.03%]
中药缓解呼吸困难的研究进展：有效性及机制的叙述性综述
Mahboobeh Ghasemzadeh Rahbardar,Mohammad Hossein Boskabady
Mahboobeh Ghasemzadeh Rahbardar
Dyspnea, a distressing symptom characterized by difficult or labored breathing, can be caused by a variety of underlying processes, including respiratory and cardiovascular problems. Despite advancements in medicine, a need remains for more...
The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary [0.03%]
大麻素受体激动剂和拮抗剂在小鼠卵巢卵泡发育及演化中的作用
Vida Mirzaie,Touba Eslaminejad,Fatemeh Sheikhbahaei et al.
Vida Mirzaie et al.
Objectives: Cannabinoids, derivatives of Cannabis sativa L., can activate the endocannabinoid system via two endogenous receptors, CB1 and CB2. This system is crucial in regulating folliculogenesis, fertility, and reprodu...