Effect of nicotine on the energy metabolism of substantia nigra cells in MPTP-induced Parkinson's disease [0.03%]
尼古丁对莫达菲尼致帕金森病黑质细胞能量代谢的影响
Nikoloz Zhgenti,Otar Bibilashvili,Mariam Shengelia et al.
Nikoloz Zhgenti et al.
Objectives: Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions globally, with no current cure despite extensive research efforts. The neurotoxin MPTP is commonly used as a PD model by ...
Resveratrol as a naturally occurring inflammasome modulator: Implications for health and disease [0.03%]
白藜芦醇作为天然的炎性小体调节物质：对健康和疾病的影响
Mahboobeh Ghasemzadeh Rahbardar,Amirhossein Sahebkar
Mahboobeh Ghasemzadeh Rahbardar
Inflammation plays a crucial role in the pathophysiology of diverse diseases, ranging from chronic disorders to acute inflammatory responses. Inflammasome, a multiprotein complex that controls the activation of pro-inflammatory cytokines an...
Repurposing Artrestan (Sacubitril/Valsartan), unveiling its anti-inflammatory and fibrinolytic properties in ulcerative colitis in rats [0.03%]
乌司他丁/缬沙坦在溃疡性结肠炎大鼠中的再利用：揭开其抗炎和纤维蛋白溶解特性的一项研究
Khatereh Kharazmi,Seyedeh Elnaz Nazari,Moein Eskandari et al.
Khatereh Kharazmi et al.
Objectives: Ulcerative colitis (UC) is an inflammatory disorder that is managed with various treatments, which have varying degrees of effectiveness and side effects, highlighting the need for new and more effective alter...
Ischemic stroke rehabilitation through endurance training of varying intensity and duration in male Sprague-Dawley rats [0.03%]
不同强度和持续时间的耐力训练对雄性SD大鼠缺血性卒中康复的影响
Moein Fasihiyan,Maryam Nourshahi,Maryam Taheri et al.
Moein Fasihiyan et al.
Objectives: This research aimed to investigate the effect of 2 types of exercise on apoptosis, neurogenesis, and angiogenesis factors in the penumbra area of stroke during the rehabilitation period after stroke. ...
Induction of the STING-dependent DNA damage pathway by cucurbitacin B enhances immunotherapy efficacy in osteosarcoma [0.03%]
B黄瓜素通过诱导STING依赖性的DNA损伤通路增强免疫治疗在骨肉瘤中的疗效
Bin Luo,Qing Lu,Qiang Wang et al.
Bin Luo et al.
Objectives: Osteosarcoma (OS) is a highly aggressive bone tumor with limited therapeutic options. Cucurbitacin B (CuB), a natural compound derived from Cucurbitaceae plants, has demonstrated antitumor activity in various ...
Effects of Nrf-2/HO-1, NF-κB/Cox-2/TLR-4, and Bax/Bcl-2/caspase-3 pathways in alleviating azithromycin-induced cardiotoxicity in rats: Potential cardioprotective role of crocin [0.03%]
姜黄素通过Nrf-2/HO-1、NF-κB/Cox-2/TLR-4和Bax/Bcl-2/caspase-3通路缓解阿奇霉素致大鼠心肌毒性的效果及潜在的心脏保护作用机制研究
Tuba Dogan,Betul Apaydin Yildirim,Kubra Asena Terim Kapakin et al.
Tuba Dogan et al.
Objectives: This study aimed to investigate the potential protective effects of crocin against azithromycin (AZ)-induced cardiotoxicity. Materials and met...
Beyond chemotherapy: Exploring tree turmeric root and nano-hydroxyapatite for neuroprotective applications [0.03%]
超越化疗：探索叶下珠根和纳米羟基磷灰石在神经保护方面的应用
Chuangen Li,Sriram Kaliamoorthy,Mariappan Vijayalakshmi
Chuangen Li
Objectives: To investigate the physicochemical properties, in vitro efficacy, and in vivo therapeutic potential of novel tree turmeric root and nano-hydroxyapatite (TRE@NHA) composites in mitigating chemotherapy-induced p...
CRISPR/Cas9 in colorectal cancer: Revolutionizing precision oncology through genome editing and targeted therapeutics [0.03%]
基于CRISPR/Cas9的结直肠癌研究：通过基因编辑和靶向治疗精准肿瘤医学的新突破
Bahjat Alhasso,Abdulkareem Shareef,Lalji Baldaniya et al.
Bahjat Alhasso et al.
Colorectal cancer (CRC) remains a significant global health challenge, necessitating advanced molecular therapies to improve outcomes. The CRISPR/Cas9 genome-editing platform has emerged as a transformative tool in CRC research, enabling pr...
Evaluation of Cherenkov-induced photodynamic therapy of biohybrid photosensitive graphene oxide nanoplatform in cervical cancer cells [0.03%]
用于评估生物杂化光敏石墨烯纳米平台在宫颈癌细胞中切伦科夫诱导的光动力治疗效果的研究
Mona Alikhanzadeh,Armin Imanparast,Elham Einafshar et al.
Mona Alikhanzadeh et al.
Objectives: During radiotherapy, weak photons of Cherenkov radiation are generated, which can cause a relative increase in tumor resistance and cause errors in the radiotherapy treatment planning process. In this study, w...
Investigation of protective effects of rutin/cyclodextrin inclusion complex against testicular damage caused by diisononyl phthalate in rats [0.03%]
芦丁/环糊精包合物对迪异壬基酞酸致大鼠睾丸损伤的保护作用研究
Ramazan Bozali A,Serkan Ali Akarsu,Cihan Gür et al.
Ramazan Bozali A et al.
Objectives: The aim of this study was to investigate the protective effects of Rutin/cyclodextrin (RUT/CD) complex in rats exposed to diisononyl phthalate (DINP). ...