Anti-inflammatory and anti-oxidant efficacy of origanum species and honey in a rat model of COPD [0.03%]
四种百里香和蜂蜜对COPD大鼠模型的抗炎抗氧化功效研究
Fadime Ovali,Hüsamettin Vatansev,Hakan Vatansev et al.
Fadime Ovali et al.
Objectives: Chronic obstructive pulmonary disease (COPD) is a progressive airway condition characterized by chronic inflammation, oxidative stress, and tissue remodeling. Conventional treatments offer limited benefits in ...
Cardiovascular effects of ventrolateral periaqueductal gray (vlPAG) AT1 receptors in normotensive and hemorrhagic rats [0.03%]
正常血压和失血性高血压大鼠纹状体外侧腹腔AT1受体的心血管效应
Esmaeil Hamounpeyma,Reza Mohebbati,Mohammad Naser Shafei
Esmaeil Hamounpeyma
Objectives: The ventrolateral periaqueductal gray (vlPAG) regulates cardiovascular function. Given the presence of Angiotensin II (AngII) and its AT1 receptors (AT1R) in the vlPAG, this study investigated their central an...
An in vivo study on sonodynamic effects mediated by nanomicelles containing PpIX as a sonosensitizing agent [0.03%]
叶酸修饰载原卟啉钠纳米胶束的声动力效应研究
Maryam Bakhshizadeh,Mehdi Hoseini,Samaneh Soudmand Salarabadi et al.
Maryam Bakhshizadeh et al.
Objectives: Sonodynamic therapy (SDT) is a promising non-invasive adjuvant approach for treating accessible tumors, requiring ultrasound (US) waves, sonosensitizing molecules, and oxygen. However, sonosensitizers such as ...
Syringic acid attenuates LPS-induced acute lung injury via modulation of the HMGB1/TLR4/NF-κB and Keap1/Nrf2/HO-1 pathways: Mechanistic insights from in vivo and in silico studies [0.03%]
丁香酸通过调节体内和体外HMGB1/TLR4/NF-κB和Keap1/Nrf2/HO-1通路减轻LPS诱导的急性肺损伤：机制见解
Burak Batuhan Lacin,Emin Sengul,Serkan Yildirim et al.
Burak Batuhan Lacin et al.
Objectives: Sepsis-induced acute lung injury (ALI), driven by uncontrolled inflammation and oxidative stress, remains a major cause of mortality in critically ill patients. This study aimed to investigate the protective a...
Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats [0.03%]
聚(甲基乙烯基醚-共-马来酸)纳米颗粒鼻给药提高卵巢切除大鼠氯米芬氢氯化物生物利用度
Ladan Dayani,Jaleh Varshosaz,Mohsen Minaiyan
Ladan Dayani
Objectives: To improve the low bioavailability of Raloxifene hydrochloride (RH), which is just 2% through oral administration, an in situ mucoadhesive thermoreversible gel loaded with RH nanoparticles was formulated using...
The role of oxidative stress in sleep deprivation-induced reproductive dysfunction: A rationale for anti-oxidant intervention [0.03%]
氧化应激在睡眠剥夺诱导的生殖功能障碍中的作用及抗氧化干预的必要性
Keke Chen,Kaixing Huang,Xiaoyu Liu et al.
Keke Chen et al.
Sleep deprivation (SD) is a significant risk factor for reproductive dysfunction. This review aims to synthesize evidence establishing that oxidative stress (OS) is the key pathological mediator of SD-induced reproductive impairments in bot...
Hispidulin: A potential antihyperglycemic and anti-oxidant agent-mechanistic insights into its modulatory effects on PI3K, AKT, mTOR, IRS1, GSK-3β, and GLUT-4 pathways through in vitro and in vivo studies [0.03%]
山柰酚茋：潜在的抗高血糖和抗氧化剂—通过体外和体内研究探讨其对PI3K、AKT、mTOR、IRS1、GSK-3β和GLUT-4途径调节作用的机制
Muhammad Saad Tariq,Wafa Majeed,Bilal Aslam et al.
Muhammad Saad Tariq et al.
Objectives: Hispidulin, a naturally occurring flavonoid with neuroprotective and anticancer properties, has shown therapeutic potential for the treatment of metabolic disorders, including diabetes mellitus. This study was...
An in vivo evaluation of the antifibrotic potential of inulin against bile duct ligation-induced liver fibrosis [0.03%]
菊粉对胆管结扎诱导的肝纤维化的抗纤维化潜力的体内评价
Yasaman Habibian-Fard,Mahsa Ale-Ebrahim,Parvaneh Mohseni-Moghaddam et al.
Yasaman Habibian-Fard et al.
Objectives: Hepatic fibrosis is a major cause of liver-related mortality worldwide. This study evaluated the hepatoprotective and antifibrotic effects of inulin, a natural polysaccharide, in a rat model of cholestasis ind...
Protocatechuic acid mitigates diazinon-induced lung injury in rats through modulation of oxidative stress, inflammatory, Keap-1/Nrf-2/HO-1 and ER stress-mediated apoptotic pathways [0.03%]
没食子酸通过调节氧化应激、炎症、Keap-1/Nrf-2/HO-1和内质网介导的凋亡信号通路来缓解敌敌畏引起的肺损伤
Tuba Karaarslan,Omercan Alat,Ismail Can et al.
Tuba Karaarslan et al.
Objectives: Diazinon (DZN), a widely used organophosphate pesticide, induces pulmonary toxicity through oxidative stress, inflammation, endoplasmic reticulum (ER) stress, and apoptosis. This study investigated the potenti...
Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study [0.03%]
通过不同给药途径使用纳米复合物增强氯米帕明的抗抑郁效果：一项比较研究
Abeer Salama,Rabab Kamel,Nourina N Ghoneim et al.
Abeer Salama et al.
Objectives: Enhancing clomipramine anti-depressive effect using a nanoformulation and investigating its effect via different routes of administration (oral and intranasal) in a depression rat model. Polyelectrolytes nanoc...