Dapagliflozin improves diabetic cardiomyopathy by suppressing the STAT3-YY1 signaling axis in cardiac fibroblasts [0.03%]
达格列净通过抑制心脏成纤维细胞中STAT3-YY1信号轴改善糖尿病心肌病
Xing-Yi Shen,Xi-Ya Li,Zuo-Ying Hu et al.
Xing-Yi Shen et al.
Objectives: Cardiac fibroblast (CF) proliferation and activation drive cardiac fibrosis and heart failure. Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, ameliorates diabetic cardiomyopathy (DCM...
Syringic acid, a promising natural compound for the prevention and management of metabolic syndrome: A systematic review [0.03%]
丁香酸：一种很有前景的用于预防和管理代谢综合征的天然化合物——系统评价研究
Habibeh Mashayekhi-Sardoo,Fatemeh Sadeghzadeh,Maryam Rameshrad et al.
Habibeh Mashayekhi-Sardoo et al.
In recent years, because of the changes in modern lifestyles, the incidence of metabolic syndrome (MetS) has been increasing. MetS is a cluster of conditions, including hypertension, insulin resistance, hyperlipidemia, and obesity, that occ...
Effect of TGF-β1 transfected dental pulp derived mesenchymal stem cells on ın vivo cartilage regeneration [0.03%]
TGF-β1基因修饰牙髓间充质干细胞的成软骨分化及体内促进软骨再生的作用研究
Betul Tekin Alpargu,Saim Ozdamar,Zeynep Burcin Gonen et al.
Betul Tekin Alpargu et al.
Objectives: This study aimed to investigate the effect of TGF-β1-transfected dental pulp-derived mesenchymal stem cells (DP-MSCs) on the regeneration of osteochondral defects in rabbit knee joints. ...
Recent advances in the genetic engineering of the Leishmania parasite and anti-cancer properties [0.03%]
近年来利什曼原生质体的基因工程学及抗肿瘤性最新研究进展
Saeid Rahim,Hossein Yousofi Darani,Hossein Khanahmad et al.
Saeid Rahim et al.
Leishmaniasis is a tropical disease caused by Leishmania species, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Advances in genetic engineering technologies, particularly CRISPR/Cas9, plasmi...
Enhanced wound healing through hydrogel: Arthrospira platensis and Chlorella vulgaris in carboxymethyl cellulose/ carboxymethyl chitosan/gelatin matrix with decellularized amniotic membrane in male Wistar rats [0.03%]
通过水凝胶促进伤口愈合：以假蔓丝藻和裂殖壶菌为原料的羧甲基纤维素/ 羧甲基壳聚糖/明胶基质与脱细胞羊膜在雄性威斯特大鼠中的应用研究
Rasoul Kheradmandi,Mohammad Kamalabadi Farahani,Morteza Alizadeh et al.
Rasoul Kheradmandi et al.
Objectives: Wound healing requires effective biomaterials to overcome the limitations of conventional treatments, especially for full-thickness injuries. This study introduces an innovative hydrogel composed of carboxymet...
Exosomes from miR-149-3p-transfected menstrual blood-derived mesenchymal stem cells ameliorate inflammation and migration of endometriosis cells [0.03%]
miR-149-3p转染的月經血源性間充質幹細胞分泌的小囊泡改善子宮內膜異位细胞的炎症和迁移
Hoda Fazaeli,Nasim Hayati Roodbari,Ehsan Ehsani et al.
Hoda Fazaeli et al.
Objectives: Endometriosis carries remarkable social, public health, and financial consequences. Based on two theories of retrograde menstruation and stem cells, menstrual blood-derived stem cells (MenSCs) play a significa...
Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats [0.03%]
芥子气致大鼠急性肺损伤后凋亡相关基因和蛋白表达变化
Tao Liu,Jingtong Li,Xiaoxuan Hu et al.
Tao Liu et al.
Objectives: Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury. This study aimed to evaluate the apoptosis following SM-in...
A20 inhibits doxorubicin-induced macrophage maturation and apoptosis through mTOR signaling in classical Hodgkin lymphoma [0.03%]
A20通过mTOR信号抑制多柔比星诱导的巨噬细胞成熟和凋亡在经典霍奇金淋巴瘤中的作用
Nguyen Xuan Canh,Phan Thi Hoai Trang,Pham Thi Huong et al.
Nguyen Xuan Canh et al.
Objectives: Classical Hodgkin lymphoma (cHL) is identified by the appearance of Hodgkin and Reed-Sternberg cells. A20 and CYLD are deubiquitinating enzymes involved in negatively regulating NF-κB-mediated immune response...
Cardioprotective effects of lycopene-loaded nanoparticles against isoproterenol-induced myocardial injury [0.03%]
富含番茄红素纳米粒的心肌保护作用及其对异丙肾上腺素致小鼠心肌损伤的影响
Xia Liu,Ya Liu,Chunwei Yu et al.
Xia Liu et al.
Objectives: This study aimed to investigate the cardioprotective effects of lycopene loaded ovalbumin chitosan nanoparticle (L-OCNPs) against isoproterenol (ISO)-induced myocardial injury. ...
Overexpression of miRNA-216 in exosomes derived from umbilical cord mesenchymal stem cells promotes angiogenesis and improves functional recovery after spinal cord injury [0.03%]
来源于脐带间充质干细胞的外泌体中miRNA-216过表达促进血管生成并改善脊髓损伤后的功能恢复
Hengde Li,Renfeng Yi,Youbing Fan et al.
Hengde Li et al.
Objectives: This study aimed to engineer miR-216-overexpressing umbilical cord mesenchymal stem cells (UCMSCs) to generate miR-216-enriched UCMSC-derived exosomes (UCMSC-Exos) and evaluate their therapeutic potential in S...