Plasma exosomal miR-142-3p induced by acupuncture protects against heart injury in rats with myocardial infarction by targeting Cofilin 2 [0.03%]
电针诱导血浆外泌体miR-142-3p通过靶向Cofilin 2防治心肌梗死大鼠心脏损伤
Yue Zhao,Ying Wang,Chunrong Guo et al.
Yue Zhao et al.
Objectives: The protective effects of acupuncture on myocardial injury have been identified in clinical trials. However, there is still a lack of comprehensive understanding of its fundamental mechanism. This research aim...
Evaluating the effect of fucoidan-alginate combined dressing on wound healing in rats with full-thickness skin removed [0.03%]
evaluation of the effects of fucoidan-alginate combined dressings on full thickness wound repair in rats
Guifa Wang,Nan Zhang,Xiaochen Zhang et al.
Guifa Wang et al.
Objectives: This study aims to investigate the effects of fucoidan-alginate combined dressings on wound healing in rats with full-thickness skin defects and to explore the underlying mechanisms. ...
Silymarin exerts antipsoriatic effects against imiquimod-induced psoriasis in mice via NF-kB/TLR4 signaling pathway [0.03%]
水飞蓟素通过NF-κB/TLR4信号通路在咪喹莫德诱导的小鼠银屑病中发挥抗银屑病作用
Behnaz Azimi,Amir Kiani,Tayebeh Noori et al.
Behnaz Azimi et al.
Objectives: Psoriasis is an autoimmune disease that mainly affects the skin and joints, which is mediated via T-cells. Several factors contribute to its pathogenesis, including genetic and environmental triggers, as well ...
Evaluation of myocardial classic and alternative pathways of the renin-angiotensin system in cholestasis-induced cardiac injury: A time-course experimental study in rats [0.03%]
胆汁淤积性心肌损伤大鼠模型中肾素血管紧张素系统经典途径和替代途径的评估：一项时间进程实验研究
Azadeh Khalili,Parham Samimisedeh,Mohammad Maleki et al.
Azadeh Khalili et al.
Objectives: Cholestasis, characterized by impaired bile flow and elevated bile acid levels, can lead to cardiac dysfunction, termed Cholecardia syndrome. The pathophysiology of cholestasis-induced cardiac injury involves ...
Elucidating the effect of deferoxamine, a hypoxia mimetic agent, on angiogenesis restoration in endothelial progenitor cells (EPCs) from diabetic mice [0.03%]
脱铁胺（一种缺氧模拟剂）对糖尿病小鼠内皮祖细胞血管生成恢复的影响机制研究
Vahid Siavashi,Seyed Mahdi Nassiri,Mahdi Farhadi Mahalli et al.
Vahid Siavashi et al.
Objectives: Diabetes increases the risk of heart disease and stroke, primarily through endothelial cell dysfunction and vascular damage. These vascular complications are partly due to defects in endothelial progenitor cel...
Anti-inflammatory and immunomodulatory effects of camel milk exosomes (CM-Exo) in rat models for burn wound healing [0.03%]
骆驼奶外泌体对烧伤小鼠模型伤口愈合的抗炎和免疫调节作用研究
Ehsaneh Azaryan,Asghar Zarban,Effat Alemzadeh et al.
Ehsaneh Azaryan et al.
Objectives: Camel milk contains proteins with several beneficial characteristics, such as immune-modulating and anti-oxidant effects. Recent research has shown that these benefits are primarily due to extracellular nanove...
Troxerutin attenuates LPS-induced inflammation in BV2 microglial cells involving Nrf2 activation and NF-κB pathway inhibition [0.03%]
芸香苷通过激活Nrf2和抑制NF-κB信号通路减轻LPS诱导的小胶质BV2细胞炎症反应
Shengnan Ma,Hongguang Fan,Jianhong Zhang et al.
Shengnan Ma et al.
Objectives: Microglial cell-mediated neuroinflammation is a key driver of central nervous system (CNS) homeostasis and a significant risk factor for neurodegeneration and development of neurological diseases. We assessed ...
Linalool vs linalool-loaded chitosan nanoparticles in an Aβ-induced rat model of Alzheimer's disease: A molecular, biochemical, histological, and behavioral study [0.03%]
香芹酚及其壳聚糖纳米颗粒在阿尔茨海默病模型大鼠中的药理学研究：分子、生化、组织病理和行为学研究
Mohammad Pakdel,Masoumeh Asle-Rousta,Mehdi Sadegh et al.
Mohammad Pakdel et al.
Objectives: Recent studies have increasingly focused on applying nanotechnology to treat neurodegenerative diseases. In this study, we compared the effects of the monoterpene linalool and linalool-loaded chitosan nanopart...
Impact of trehalose and hydroxychloroquine on the function of BRAF (V600E)-siRNA in the A375 melanoma cells [0.03%]
trehalose和羟氯喹对BRAF(V600E)-siRNA在A375黑色素瘤细胞中功能影响的研究
Elmira Toobchi,Rana Moradian Tehrani,Mohammadreza Sharifi et al.
Elmira Toobchi et al.
Objectives: Melanoma, a lethal form of skin cancer, is closely linked to mutations in melanocytes. Due to increased resistance to chemotherapy, innovative strategies, including gene and combination therapies, are being ex...
Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway [0.03%]
生酮饮食预处理通过PGC-1α/Sirt1/Nrf1信号通路抑制脊髓损伤模型大鼠线粒体损伤
Xiaomeng Wang,Weibin Lan,Yang Liao et al.
Xiaomeng Wang et al.
Objectives: Spinal cord injury (SCI) often results in poor recovery prospects and a high disability rate. Although the ketogenic diet (KD) was suggested as a neuroprotective agent after SCI, its underlying mechanism remai...