Effect of chitosan nanoparticles loaded with platelet lysate on in vitro fertilization and early embryo development in a mouse premature ovarian failure model [0.03%]
壳聚糖纳米粒负载血小板释放液对卵巢早衰小鼠体外受精及早期胚胎发育的影响
Fereshte Torabi,Sareh Karimi,Fatemeh Alipour et al.
Fereshte Torabi et al.
Objectives: Premature ovarian failure (POF) is a common cause of women's infertility. Cyclophosphamide (CP) is one of the most important gonadotoxic agents that lead to POF. This study aimed to evaluate the potential ther...
Facile fabrication of selegiline-loaded alginate hydrogel for neuroprotection and functional recovery in a rat model of spinal cord injury through localized spinal delivery [0.03%]
一种用于脊髓损伤的透骨コ辛富马酸酯-海藻酸盐水凝胶的局部脊髓递送方法及其对神经保护和功能恢复的作用研究
Ramin Abrishami,Ramtin Farhadi,Mehri Farhang Ranjbar et al.
Ramin Abrishami et al.
Objectives: Spinal cord injury (SCI) is a highly disabling and fatal disorder with no effective treatment to date. Selegiline, a selective MAO-B inhibitor, has shown new neuroprotective and neurorescuing effects with vari...
Apigenin attenuates myocardial ischemia-reperfusion injury through miR-448/SIRT1 axis [0.03%]
染料木素通过miR-448/SIRT1轴减轻心肌缺血再灌注损伤
Chenchen Tian,Bo Yu,Yibo Liu et al.
Chenchen Tian et al.
Objectives: Myocardial ischemia/reperfusion injury (MIRI) is the primary pathological injury following ischemic cardiomyocyte therapy, but there are few effective treatments available for MIRI. Apigenin (API) is an active...
Amantadine reduces sepsis-induced brain injury via NLRP3/caspase-1 inflammasome activation [0.03%]
氨酚啶通过NLRP3/半胱天冬酶-1炎性小体活化降低脓毒症引起的脑损伤
Pınar Karabacak,Ahmet Bindal,Mustafa Soner Ozcan et al.
Pınar Karabacak et al.
Objectives: Sepsis, a severe consequence of infection leading to organ failure, incites damage in frequently affected brain tissue through inflammation and oxidative stress. This study aimed to assess the effectiveness of...
Simultaneous effect of naringenin and beta-catenin signaling inhibitor C-82 on modulating gene expression and functional pattern of mesenchymal stem cells from endometriosis patients [0.03%]
芸苔素和β-连环蛋白信号抑制剂C-82对子宫内膜异位症间充质干细胞基因表达及功能模式的联合作用研究
Hoda Fazaeli,Faezeh Davoodi,Azar Sheikholeslami et al.
Hoda Fazaeli et al.
Objectives: One of the leading causes of endometriosis is the return of menstrual blood flow into the pelvic cavity and the establishment of menstrual blood mesenchymal stem cells (MenSCs) outside the uterus. MenSCs from ...
Endurance training promotes the browning of WAT by enhancing the NPFF pathway in the hypothalamus in rats with type 2 diabetes [0.03%]
耐力训练通过增强下丘脑NPFF通路促进2型糖尿病大鼠WAT褐变化
Syiedeh Maryam Mousavi,Fatemeh Zahra Gorji,Ziya Fallahmohammadi et al.
Syiedeh Maryam Mousavi et al.
Objectives: Type 2 diabetes (T2D) represents a complex and multifactorial disorder, and efforts to discover its treatment are necessary. Browning of white adipose tissue (WAT) as a therapeutic target for diabetes seems to...
Investigation of the molecular and cellular effects of Shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in rats [0.03%]
喜马拉雅紫河车对5-氟尿嘧啶致大鼠肾毒性的分子及细胞效应研究
Mehmet Ezer,Melek Öztürkler,Kezban Yıldız-Dalgınlı et al.
Mehmet Ezer et al.
Objectives: This study aimed to evaluate the protective effects of shilajit on 5-fluorouracil (5-FU)-induced nephrotoxicity in a rat model. Materials and ...
Heterogeneous expression of long noncoding RNA RP11-109D20.2: Insights into regulatory gene expression roles in colon cancer [0.03%]
长链非编码RNA RP11-109D20.2在结直肠癌中异质表达：对调节基因表达作用的启示
Sara Chitgaran,Reihaneh Alsadat Mahmoudian,Seyed Saeed Khatami et al.
Sara Chitgaran et al.
Objectives: Colorectal cancer is one of the deadliest cancers worldwide, which can be prevented and even cured by early diagnosis and more efficient treatment modalities. Comprehensive transcriptional analysis has highlig...
Sinapic acid attenuated nephrotoxicity against Cyclophosphamide in mice model: A histochemical, immunohistochemical and histopathological evaluation [0.03%]
sinapic酸减轻环磷酰胺小鼠模型肾毒性：基于组织化学、免疫组织化学和病理学的评估
Saeed Raoof,Shiva Rezaei,Mehryar Zargari et al.
Saeed Raoof et al.
Objectives: Cyclophosphamide (CP) is a chemotherapeutic drug used to treat various tumors. It causes nephrotoxicity by producing reactive oxygen species. Sinapic acid (SA) exhibits anti-oxidant, antiapoptotic, and anti-in...
Advancing cancer treatment with nanozyme frameworks: Integrating photothermal, photodynamic, sonodynamic, and chemodynamic therapies [0.03%]
基于纳米酶框架的癌症治疗研究进展：光热、光动力、声动力及化学动力疗法一体化
Seyed Mohammad Mahdi Rais Sadati,Javad Zamanian,Mohammad Moshiri et al.
Seyed Mohammad Mahdi Rais Sadati et al.
Cancer is considered a serious threat to human life and one of the major leading causes of death in the world. As a critical medical challenge in developing and developed countries globally, progress in the design of theranostic nanomedicin...