Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study [0.03%]
通过不同给药途径使用纳米复合物增强氯米帕明的抗抑郁效果：一项比较研究
Abeer Salama,Rabab Kamel,Nourina N Ghoneim et al.
Abeer Salama et al.
Objectives: Enhancing clomipramine anti-depressive effect using a nanoformulation and investigating its effect via different routes of administration (oral and intranasal) in a depression rat model. Polyelectrolytes nanoc...
Parthenolide attenuated the endometriosis-like lesions by activating autophagy and suppressing NLRP3 inflammasome activity [0.03%]
_parthenolide通过激活自噬和抑制NLRP3炎性小体活性来减轻子宫内膜异位症样病变
Luhongyuan Jin,Tingting Fu,Chi Chi et al.
Luhongyuan Jin et al.
Objectives: Parthenolide (PTL) has significant anti-inflammatory and immunomodulatory effects, but its regulatory mechanisms in endometriosis (EMs) remain unclear. This study aimed to systematically evaluate the effects o...
Priyanka Arya,Vikram Sharma,Priyanka Singh et al.
Priyanka Arya et al.
Inflammation is a natural immune response triggered by multiple factors such as pathogens, damaged cells, and toxic substances. These triggers can lead to both acute and chronic inflammatory reactions in different tissues, contributing to t...
Electroacupuncture improves hypoxic stress and energy metabolism to alleviate vascular cognitive impairment through activation of the HIF-1α/p53/NGB signaling pathway in rats [0.03%]
电针通过激活HIF-1α/p53/NGB信号通路改善缺氧应激和能量代谢以缓解大鼠血管性认知障碍的研究
Peijia Hu,Fangyuan Xu,Wendong Zhang et al.
Peijia Hu et al.
Objectives: We aimed to demonstrate that electroacupuncture (EA) alleviates vascular cognitive impairment (VCI) induced by cerebral ischemia in rats by modulating oxygen homeostasis and energy metabolism through the HIF-1...
Neuroprotective effects of kojic acid and nano-kojic acid in experimental brain ischemia induced by bilateral common carotid artery occlusion [0.03%]
没食子酸和纳米没食子酸对双侧颈总动脉阻塞引起的脑缺血的神经保护作用
Mohammad Shokati Sayyad,Majid Saeedi,Fatemeh Shaki et al.
Mohammad Shokati Sayyad et al.
Objectives: Brain ischemia remains a leading cause of death and neurological disability worldwide, with current treatments limited by narrow therapeutic windows and insufficient neuroprotection. Kojic acid (KA), a natural...
Amarogentin relieves cholestatic liver injury caused by ANIT in rats by regulating the FXR and Nrf2 pathways [0.03%]
异熊果素通过调节法尼醇X受体和核因子E2相关因子信号通路缓解氨基取代胆汁酸所致肝内胆汁淤积的肝脏损伤
Wenxiang Wang,Wei Xiong,Jingxin Mao et al.
Wenxiang Wang et al.
Objectives: Cholestasis, a hepatic disorder characterized by impaired bile secretion, drives progressive liver damage, fibrosis, failure, and even death. This study explores how amarogentin (AG) ameliorates cholestatic li...
Ashwagandha (Withania somnifera) in insulin resistance and metabolic syndrome: A literature review on mechanisms [0.03%]
阿育吠陀草药阿什瓦甘达(Withania somnifera)改善胰岛素抵抗和代谢综合征的机制研究进展
Emad Azimi,Maryam Rameshrad,Mahboobeh Ghasemzadeh Rahbardar et al.
Emad Azimi et al.
Metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia, and hypertension. Withania somnifera, commonly known as ashwagandha or Indian winter cherry, belongs to the Solanaceae family. W. somnifera, particularly its ...
18β-Glycyrrhetinic acid-loaded silver nanoparticles mitigate neuroinflammation and endoplasmic reticulum stress in the brain tissue of diabetic rats [0.03%]
甘草酸负载的银纳米颗粒可缓解糖尿病大鼠脑组织神经炎症和内质网应激
Seçil Nazife Parlak,Seda Yakut,Adem Kara et al.
Seçil Nazife Parlak et al.
Objectives: Diabetes mellitus (DM) causes oxidative stress, neuroinflammation, and endoplasmic reticulum (ER) dysfunction that contribute to neurodegeneration. This study investigated the effects of 18β-glycyrrhetinic ac...
The effect of tert-butylhydroquinone on anxiolytic- and antidepressant-like behaviors induced by post-traumatic stress disorder: A behavioral and molecular study [0.03%]
叔丁基对苯二酚对创伤后应激障碍诱导的抗焦虑和抗抑郁样行为的影响：一项行为学及分子学研究
Samaneh Nabavi,Mohammad-Reza Zarrindast,Fariba Khodagholi et al.
Samaneh Nabavi et al.
Objectives: Post-traumatic stress disorder (PTSD) is a crippling mental illness that commonly co-occurs with anxiety and depression. Recent studies have established a link between neuroinflammation and the development of ...
Artificial intelligence (AI) in academic publishing: Legitimate use, plagiarism detection, and ethical challenges [0.03%]
人工智能与学术出版：合法使用、剽窃检测及伦理挑战
Leila Arabi,Ali Roohbakhsh,Bizhan Malaekeh-Nikouei et al.
Leila Arabi et al.
Objectives: This study aimed to determine the effect of 8-week high-intensity interval training (HIIT) on oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes (T2D). The study focused on exa...