Beyond gluten: the multifaceted regulation of MHC class II in celiac disease pathogenesis [0.03%]
无麦胶不自律：II类主要组织相容性复合体在乳糜泻发病机制中的多重调控作用
Nastaran Asri,Mohadeseh Mahmoudi Ghehsareh,Armina Assarin et al.
Nastaran Asri et al.
Celiac disease (CD) is a complex immune-mediated disorder influenced by genetic predispositio and environmental triggers, which human leukocyte antigen (HLA)-DQ2/8 playing a central role in disease pathogenesis. Gluten peptides deamidated b...
Microbiome-microRNA interactions in inflammatory bowel disease: insights from metagenomic and transcriptomic data analysis [0.03%]
基于元基因组和转录组数据分析探讨炎症性肠病中微生物-微小RNA的相互作用
Nesa Kazemifard,Mohammad Hossein Norouzi-Beirami,Shaghayegh Baradaran Ghavami et al.
Nesa Kazemifard et al.
Background: Inflammatory Bowel Disease (IBD) is a chronic inflammation of the gastrointestinal tract, the precise origins of which remain not fully elucidated. This study investigates the complex relationship between gut ...
Unraveling genetic signatures: the impact of SNPs on therapy response in inflammatory bowel disease patients [0.03%]
解开遗传标志物之谜：炎症性肠病患者中SNPs对治疗反应的影响
Nesa Kazemifard,Masomeh Askari,Leila Navapour et al.
Nesa Kazemifard et al.
Background: Inflammatory bowel disease (IBD) is a chronic condition characterized by immune dysregulation and intestinal inflammation, with anti-tumor necrosis factor α (anti-TNFα) therapies being a key treatment strate...
Integrative systems biology identifies PRELP and TAGLN as prognostic biomarkers and immune modulators in colorectal cancer [0.03%]
整合系统生物学在结直肠癌中鉴定出PRELP和TAGLN作为预后生物标志物和免疫调节因子
Amir Ali Judaki,Mehran Aghemiri,Zahra Yousefli et al.
Amir Ali Judaki et al.
Aim: To identify prognostic biomarkers in colorectal cancer (CRC) using an integrative systems biology approach combining transcriptomics, network topology, and immune profiling. ...
AI-driven prediction of the optimal number of bowel preparation sachets for adequate preparation before colonoscopy [0.03%]
基于人工智能的结肠镜检查前充分肠道准备所需清洗散剂袋数的最佳预测模型研究
Amir Sadeghi,Roxana Peysepar,Neda Kafash et al.
Amir Sadeghi et al.
Background: High-quality colonoscopy is critical for colorectal cancer (CRC) prevention. Suboptimal bowel preparation impairs adenoma detection and prolongs cecal intubation time (CIT). This study aimed to identify behavi...
Machine learning and microbiome analysis for early detection of pancreatic cancer [0.03%]
机器学习和微生物组分析在胰腺癌早期检测中的应用
Sogol Tavanaeian,Mohammad Mehdi Feizabadi,Sarvenaz Falsafi et al.
Sogol Tavanaeian et al.
Aim: To develop machine learning (ML) models integrating clinical and microbial predictors for early pancreatic cancer (PC) detection. Background: ...
A bioinformatics analysis to identify shared molecular pathways and hub genes between NAFLD and Gestational Diabetes Mellitus [0.03%]
一项生物信息学分析识别出非酒精性脂肪肝与妊娠期糖尿病之间的共有分子通路及核心基因
Nasrin Amiri-Dashatan,Mehdi Koushki,Masoumeh Farahani et al.
Nasrin Amiri-Dashatan et al.
Aim: This research aimed to identify the possible links between Non-alcoholic fatty liver disease (NAFLD) and gestational diabetes mellitus (GDM) by examining shared genes and pathways through the use of bioinformatics to...
Gut microbiome dysbiosis and inflammatory markers in severe COVID-19: links to atherosclerosis and potential therapeutic insights [0.03%]
肠道菌群失调和炎症标志物在重症COVID-19患者中的作用：与动脉粥样硬化及潜在治疗靶点的关系
Nayebali Ahmadi,Mohammad Javad Hossein Tehrani,Ashkan Alamdary et al.
Nayebali Ahmadi et al.
Background: COVID-19 is implicated in the exacerbation of atherosclerosis, potentially leading to its clinical manifestations. The aim of this study was to evaluate serum biomarkers, including albumin (ALB), C-reactive pr...
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 discriminates AGS and MKN45 cells of human gastric cancer [0.03%]
人胃癌AGS和MKN45细胞中脯氨酰4-羟化酶亚基β的区别表达与定位
Mostafa Rezaei-Tavirani,Farideh Razi,Fatemeh Bandarian et al.
Mostafa Rezaei-Tavirani et al.
Aim: In the present study, differences between these cell lines are discovered via gene expression analysis. Background: Gastric cancer...
Analysis of complete and incomplete response to neoadjuvant therapy in rectum cancer patients [0.03%]
局部晚期直肠癌患者新辅助治疗完全和非完全病理缓解的临床特征及预后分析
Fatemeh TajikRostami,Majid Rezaei Tavirani,Elnaz Ataei et al.
Fatemeh TajikRostami et al.
Aim: Bioinformatic analysis of the differentially expressed genes (DEGs) of the two groups of patients is the main aim of this project. Background: ...